FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203706402> ?p ?o ?g. }

• W3203706402 endingPage "e08101" @default.
• W3203706402 startingPage "e08101" @default.
• W3203706402 abstract "Transthyretin (TTR) is an amyloidogenic protein associated with hereditary and nonhereditary transthyretin amyloidoses (ATTR). Dissociation of the tetramer of TTR to the monomer induces TTR misfolding, which leads to amyloid fibril formation and triggers the onset of ATTR amyloidosis. Stabilizers of tetrameric TTR have been accepted as an effective ATTR amyloidosis treatment while effect is limited and they are too expensive. The aim of our study was to find more effective and cheep natural compound to suppress TTR amyloid formation. Glabridin, a prenylated isoflavan isolated from Glycyrrhiza glabra L., stabilized the TTR tetramer in vitro. The effects of licorice-derived flavonoid oil-Glavonoid, a natural substance that includes glabridin and several polyphenols-on stabilizing the TTR tetramer must still be elucidated. To examine plasma TTR stabilization by Glavonoid in vitro, we investigated the feasibility of utilizing glabridin plus Glavonoid to prevent TTR amyloid fibril formation. Glavonoid mixed with human plasma samples at 24 h incubation in vitro increased the tetramer level (P < 0.05) and reduced the monomer level (P < 0.01) and the monomer/tetramer ratio (P < 0.05) of TTR compared to those without Glavonoid by immunoblot analysis, such effect could not observe in the presence of glabridin. Oral Glavonoid (300 mg for 12 weeks) in 7 healthy volunteers effectively increased the plasma glabridin concentration. Glavonoid increased the TTR tetramer level and reduced the monomer/tetramer ratio of TTR (P < 0.05) in plasma at 12 weeks in healthy volunteers compared to those of age matched control subjects without the supplement. Thus, oral Glavonoid may effectively prevent TTR amyloid fibril formation via TTR tetramer stabilization. Glavonoid may become a promising supplement before onset of ATTR amyloidosis." @default.
• W3203706402 created "2021-10-11" @default.
• W3203706402 creator A5006862718 @default.
• W3203706402 creator A5011533166 @default.
• W3203706402 creator A5017666745 @default.
• W3203706402 creator A5023280698 @default.
• W3203706402 creator A5046728233 @default.
• W3203706402 creator A5049147704 @default.
• W3203706402 creator A5056035618 @default.
• W3203706402 creator A5058329559 @default.
• W3203706402 creator A5060610736 @default.
• W3203706402 creator A5070720107 @default.
• W3203706402 creator A5073464264 @default.
• W3203706402 creator A5079226469 @default.
• W3203706402 date "2021-10-01" @default.
• W3203706402 modified "2023-10-12" @default.
• W3203706402 title "Glavonoid, a possible supplement for prevention of ATTR amyloidosis" @default.
• W3203706402 cites W1502019157 @default.
• W3203706402 cites W1934007967 @default.
• W3203706402 cites W1979704176 @default.
• W3203706402 cites W1982074741 @default.
• W3203706402 cites W1988213568 @default.
• W3203706402 cites W2020069228 @default.
• W3203706402 cites W2049783325 @default.
• W3203706402 cites W2093397465 @default.
• W3203706402 cites W2117942418 @default.
• W3203706402 cites W2131999691 @default.
• W3203706402 cites W2146725322 @default.
• W3203706402 cites W2160730167 @default.
• W3203706402 cites W2160966221 @default.
• W3203706402 cites W2164668128 @default.
• W3203706402 cites W2809863834 @default.
• W3203706402 cites W2897161999 @default.
• W3203706402 cites W2934233926 @default.
• W3203706402 cites W2945253146 @default.
• W3203706402 cites W2948667444 @default.
• W3203706402 doi "https://doi.org/10.1016/j.heliyon.2021.e08101" @default.
• W3203706402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8517165" @default.
• W3203706402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34693047" @default.
• W3203706402 hasPublicationYear "2021" @default.
• W3203706402 type Work @default.
• W3203706402 sameAs 3203706402 @default.
• W3203706402 citedByCount "2" @default.
• W3203706402 countsByYear W32037064022022 @default.
• W3203706402 crossrefType "journal-article" @default.
• W3203706402 hasAuthorship W3203706402A5006862718 @default.
• W3203706402 hasAuthorship W3203706402A5011533166 @default.
• W3203706402 hasAuthorship W3203706402A5017666745 @default.
• W3203706402 hasAuthorship W3203706402A5023280698 @default.
• W3203706402 hasAuthorship W3203706402A5046728233 @default.
• W3203706402 hasAuthorship W3203706402A5049147704 @default.
• W3203706402 hasAuthorship W3203706402A5056035618 @default.
• W3203706402 hasAuthorship W3203706402A5058329559 @default.
• W3203706402 hasAuthorship W3203706402A5060610736 @default.
• W3203706402 hasAuthorship W3203706402A5070720107 @default.
• W3203706402 hasAuthorship W3203706402A5073464264 @default.
• W3203706402 hasAuthorship W3203706402A5079226469 @default.
• W3203706402 hasBestOaLocation W32037064021 @default.
• W3203706402 hasConcept C121157162 @default.
• W3203706402 hasConcept C126322002 @default.
• W3203706402 hasConcept C166940927 @default.
• W3203706402 hasConcept C178790620 @default.
• W3203706402 hasConcept C179104552 @default.
• W3203706402 hasConcept C181199279 @default.
• W3203706402 hasConcept C185592680 @default.
• W3203706402 hasConcept C202751555 @default.
• W3203706402 hasConcept C2777633098 @default.
• W3203706402 hasConcept C2778201750 @default.
• W3203706402 hasConcept C2778886173 @default.
• W3203706402 hasConcept C2779134260 @default.
• W3203706402 hasConcept C2779951007 @default.
• W3203706402 hasConcept C2994168385 @default.
• W3203706402 hasConcept C3019447875 @default.
• W3203706402 hasConcept C521977710 @default.
• W3203706402 hasConcept C55493867 @default.
• W3203706402 hasConcept C71924100 @default.
• W3203706402 hasConcept C98274493 @default.
• W3203706402 hasConceptScore W3203706402C121157162 @default.
• W3203706402 hasConceptScore W3203706402C126322002 @default.
• W3203706402 hasConceptScore W3203706402C166940927 @default.
• W3203706402 hasConceptScore W3203706402C178790620 @default.
• W3203706402 hasConceptScore W3203706402C179104552 @default.
• W3203706402 hasConceptScore W3203706402C181199279 @default.
• W3203706402 hasConceptScore W3203706402C185592680 @default.
• W3203706402 hasConceptScore W3203706402C202751555 @default.
• W3203706402 hasConceptScore W3203706402C2777633098 @default.
• W3203706402 hasConceptScore W3203706402C2778201750 @default.
• W3203706402 hasConceptScore W3203706402C2778886173 @default.
• W3203706402 hasConceptScore W3203706402C2779134260 @default.
• W3203706402 hasConceptScore W3203706402C2779951007 @default.
• W3203706402 hasConceptScore W3203706402C2994168385 @default.
• W3203706402 hasConceptScore W3203706402C3019447875 @default.
• W3203706402 hasConceptScore W3203706402C521977710 @default.
• W3203706402 hasConceptScore W3203706402C55493867 @default.
• W3203706402 hasConceptScore W3203706402C71924100 @default.
• W3203706402 hasConceptScore W3203706402C98274493 @default.
• W3203706402 hasFunder F4320334764 @default.
• W3203706402 hasIssue "10" @default.

• next