Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203730253> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3203730253 abstract "Abstract Background : Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PC). In this study, we investigated a group of SNPs in Saudi individuals and compared their frequency in patients and healthy normal controls. Methods : A total of 320 individuals were included in the study: 85 with PC, 120 with benign nodular hyperplasia, and 115 healthy normal controls. DNA was extracted from paraffin-embedded formalin-fixed tissue from PC and nodular hyperplasia patients and from whole blood of healthy controls. A total of thirteen SNPs were genotyped using the TaqMan® MGB PCR assay. Results : The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequencies in PC patients than in controls (p < 0.05). The C/A genotype of the rs16901979 SNP was observed significantly more frequently in PC patients than in controls (43% vs 14%, OR = 0.2, p value = 0.0001) and more frequently in PC patients than in the benign hyperplasia group (43% vs 25%, OR = 2.3, p value = 0.03). Conclusion : Our study highlighted several SNP genotypes associated with PC development in Saudi males. These findings have important implications for diagnosing PC and screening unaffected family members of Saudi patients." @default.
- W3203730253 created "2021-10-11" @default.
- W3203730253 creator A5040054975 @default.
- W3203730253 creator A5044009345 @default.
- W3203730253 creator A5055073819 @default.
- W3203730253 date "2020-05-27" @default.
- W3203730253 modified "2023-09-25" @default.
- W3203730253 title "Single Nucleotide Polymorphisms Associated With Prostate Cancer Development in Saudi Males" @default.
- W3203730253 doi "https://doi.org/10.21203/rs.3.rs-18257/v1" @default.
- W3203730253 hasPublicationYear "2020" @default.
- W3203730253 type Work @default.
- W3203730253 sameAs 3203730253 @default.
- W3203730253 citedByCount "0" @default.
- W3203730253 crossrefType "posted-content" @default.
- W3203730253 hasAuthorship W3203730253A5040054975 @default.
- W3203730253 hasAuthorship W3203730253A5044009345 @default.
- W3203730253 hasAuthorship W3203730253A5055073819 @default.
- W3203730253 hasBestOaLocation W32037302531 @default.
- W3203730253 hasConcept C104317684 @default.
- W3203730253 hasConcept C121608353 @default.
- W3203730253 hasConcept C126322002 @default.
- W3203730253 hasConcept C135763542 @default.
- W3203730253 hasConcept C139275648 @default.
- W3203730253 hasConcept C142724271 @default.
- W3203730253 hasConcept C143660080 @default.
- W3203730253 hasConcept C143998085 @default.
- W3203730253 hasConcept C153209595 @default.
- W3203730253 hasConcept C180754005 @default.
- W3203730253 hasConcept C2777562237 @default.
- W3203730253 hasConcept C2780192828 @default.
- W3203730253 hasConcept C48023723 @default.
- W3203730253 hasConcept C54355233 @default.
- W3203730253 hasConcept C71924100 @default.
- W3203730253 hasConcept C86803240 @default.
- W3203730253 hasConcept C90924648 @default.
- W3203730253 hasConceptScore W3203730253C104317684 @default.
- W3203730253 hasConceptScore W3203730253C121608353 @default.
- W3203730253 hasConceptScore W3203730253C126322002 @default.
- W3203730253 hasConceptScore W3203730253C135763542 @default.
- W3203730253 hasConceptScore W3203730253C139275648 @default.
- W3203730253 hasConceptScore W3203730253C142724271 @default.
- W3203730253 hasConceptScore W3203730253C143660080 @default.
- W3203730253 hasConceptScore W3203730253C143998085 @default.
- W3203730253 hasConceptScore W3203730253C153209595 @default.
- W3203730253 hasConceptScore W3203730253C180754005 @default.
- W3203730253 hasConceptScore W3203730253C2777562237 @default.
- W3203730253 hasConceptScore W3203730253C2780192828 @default.
- W3203730253 hasConceptScore W3203730253C48023723 @default.
- W3203730253 hasConceptScore W3203730253C54355233 @default.
- W3203730253 hasConceptScore W3203730253C71924100 @default.
- W3203730253 hasConceptScore W3203730253C86803240 @default.
- W3203730253 hasConceptScore W3203730253C90924648 @default.
- W3203730253 hasLocation W32037302531 @default.
- W3203730253 hasOpenAccess W3203730253 @default.
- W3203730253 hasPrimaryLocation W32037302531 @default.
- W3203730253 hasRelatedWork W2056355462 @default.
- W3203730253 hasRelatedWork W2212467789 @default.
- W3203730253 hasRelatedWork W2283861756 @default.
- W3203730253 hasRelatedWork W2348076134 @default.
- W3203730253 hasRelatedWork W2388410314 @default.
- W3203730253 hasRelatedWork W2407337938 @default.
- W3203730253 hasRelatedWork W2790470715 @default.
- W3203730253 hasRelatedWork W3029468676 @default.
- W3203730253 hasRelatedWork W3055258070 @default.
- W3203730253 hasRelatedWork W4221019551 @default.
- W3203730253 isParatext "false" @default.
- W3203730253 isRetracted "false" @default.
- W3203730253 magId "3203730253" @default.
- W3203730253 workType "article" @default.