Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203733253> ?p ?o ?g. }
- W3203733253 abstract "Abstract NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in proliferation and give rise to myelinating oligodendrocytes during early brain development. In contrast to other glial cell types, the most intriguing aspect of NG2 glia is their ability to directly sense synaptic inputs from neurons. However, whether this synaptic interaction is bidirectional or unidirectional, or its physiological relevance has not yet been clarified. Here, we report that NG2 glia form synaptic complexes with hippocampal interneurons and that selective photostimulation of NG2 glia (expressing channelrhodopsin-2) functionally drives GABA release and enhances inhibitory synaptic transmission onto proximal interneurons in a microcircuit. The mechanism involves GAD67 biosynthesis and VAMP-2 containing vesicular exocytosis. Further, behavioral assays demonstrate that NG2 glia photoactivation triggers anxiety-like behavior in vivo and contributes to chronic social defeat stress." @default.
- W3203733253 created "2021-10-11" @default.
- W3203733253 creator A5001122900 @default.
- W3203733253 creator A5007980901 @default.
- W3203733253 creator A5008600682 @default.
- W3203733253 creator A5016438873 @default.
- W3203733253 creator A5025413148 @default.
- W3203733253 creator A5045436030 @default.
- W3203733253 creator A5053508776 @default.
- W3203733253 creator A5058301452 @default.
- W3203733253 creator A5058928674 @default.
- W3203733253 creator A5059014823 @default.
- W3203733253 creator A5065181617 @default.
- W3203733253 creator A5079738340 @default.
- W3203733253 creator A5083926137 @default.
- W3203733253 date "2021-09-30" @default.
- W3203733253 modified "2023-10-12" @default.
- W3203733253 title "NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety" @default.
- W3203733253 cites W1498241934 @default.
- W3203733253 cites W1523042311 @default.
- W3203733253 cites W1535553324 @default.
- W3203733253 cites W1547865271 @default.
- W3203733253 cites W1570745179 @default.
- W3203733253 cites W1594747697 @default.
- W3203733253 cites W1607280228 @default.
- W3203733253 cites W1811410135 @default.
- W3203733253 cites W1819104005 @default.
- W3203733253 cites W1894035827 @default.
- W3203733253 cites W1963788090 @default.
- W3203733253 cites W1966037459 @default.
- W3203733253 cites W1969023217 @default.
- W3203733253 cites W1972124891 @default.
- W3203733253 cites W1976152949 @default.
- W3203733253 cites W1978885851 @default.
- W3203733253 cites W1984390450 @default.
- W3203733253 cites W1989756662 @default.
- W3203733253 cites W1990469587 @default.
- W3203733253 cites W1992521533 @default.
- W3203733253 cites W1995731471 @default.
- W3203733253 cites W2004727018 @default.
- W3203733253 cites W2005096312 @default.
- W3203733253 cites W2007604466 @default.
- W3203733253 cites W2016740368 @default.
- W3203733253 cites W2021199403 @default.
- W3203733253 cites W2023732600 @default.
- W3203733253 cites W2024596688 @default.
- W3203733253 cites W2034468530 @default.
- W3203733253 cites W2036067700 @default.
- W3203733253 cites W2041102906 @default.
- W3203733253 cites W2043636741 @default.
- W3203733253 cites W2044191383 @default.
- W3203733253 cites W2044730840 @default.
- W3203733253 cites W2049212652 @default.
- W3203733253 cites W2050989030 @default.
- W3203733253 cites W2051147967 @default.
- W3203733253 cites W2051381362 @default.
- W3203733253 cites W2059276463 @default.
- W3203733253 cites W2061960110 @default.
- W3203733253 cites W2064037757 @default.
- W3203733253 cites W2065031748 @default.
- W3203733253 cites W2068767807 @default.
- W3203733253 cites W2070749396 @default.
- W3203733253 cites W2076163730 @default.
- W3203733253 cites W2076310752 @default.
- W3203733253 cites W2079823127 @default.
- W3203733253 cites W2087045924 @default.
- W3203733253 cites W2089521828 @default.
- W3203733253 cites W2101934599 @default.
- W3203733253 cites W2106923521 @default.
- W3203733253 cites W2110309782 @default.
- W3203733253 cites W2111038577 @default.
- W3203733253 cites W2111638415 @default.
- W3203733253 cites W2113150099 @default.
- W3203733253 cites W2113679292 @default.
- W3203733253 cites W2133777156 @default.
- W3203733253 cites W2138171809 @default.
- W3203733253 cites W2141041835 @default.
- W3203733253 cites W2144137250 @default.
- W3203733253 cites W2147372806 @default.
- W3203733253 cites W2148787277 @default.
- W3203733253 cites W2149809624 @default.
- W3203733253 cites W2151093700 @default.
- W3203733253 cites W2159423248 @default.
- W3203733253 cites W2164236178 @default.
- W3203733253 cites W2166043619 @default.
- W3203733253 cites W2167095271 @default.
- W3203733253 cites W2168078141 @default.
- W3203733253 cites W2176978669 @default.
- W3203733253 cites W2193807270 @default.
- W3203733253 cites W2224978811 @default.
- W3203733253 cites W2252453655 @default.
- W3203733253 cites W2501957447 @default.
- W3203733253 cites W2568440018 @default.
- W3203733253 cites W2573810967 @default.
- W3203733253 cites W2580268626 @default.
- W3203733253 cites W2602913643 @default.
- W3203733253 cites W2747200165 @default.
- W3203733253 cites W2765925057 @default.
- W3203733253 cites W2782347462 @default.
- W3203733253 cites W2783481291 @default.