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- W3203754807 endingPage "10513" @default.
- W3203754807 startingPage "10513" @default.
- W3203754807 abstract "Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, affecting more than 33 million people worldwide. Despite important advances in therapy, AF's incidence remains high, and treatment often results in recurrence of the arrhythmia. A better understanding of the cellular and molecular changes that (1) trigger AF and (2) occur after the onset of AF will help to identify novel therapeutic targets. Over the past 20 years, a large body of research has shown that intracellular Ca2+ handling is dramatically altered in AF. While some of these changes are arrhythmogenic, other changes counteract cellular arrhythmogenic mechanisms (Calcium Signaling Silencing). The intracellular Na+ concentration ([Na+])i is a key regulator of intracellular Ca2+ handling in cardiac myocytes. Despite its importance in the regulation of intracellular Ca2+ handling, little is known about [Na+]i, its regulation, and how it might be changed in AF. Previous work suggests that there might be increases in the late component of the atrial Na+ current (INa,L) in AF, suggesting that [Na+]i levels might be high in AF. Indeed, a pharmacological blockade of INa,L has been suggested as a treatment for AF. Here, we review calcium signaling silencing and changes in intracellular Na+ homeostasis during AF. We summarize the proposed arrhythmogenic mechanisms associated with increases in INa,L during AF and discuss the evidence from clinical trials that have tested the pharmacological INa,L blocker ranolazine in the treatment of AF." @default.
- W3203754807 created "2021-10-11" @default.
- W3203754807 creator A5038071679 @default.
- W3203754807 creator A5055892044 @default.
- W3203754807 creator A5063224703 @default.
- W3203754807 creator A5074067301 @default.
- W3203754807 date "2021-09-29" @default.
- W3203754807 modified "2023-10-17" @default.
- W3203754807 title "Calcium Signaling Silencing in Atrial Fibrillation: Implications for Atrial Sodium Homeostasis" @default.
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