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• W3203788909 abstract "Pseudomyogenic hemangioendothelioma (PHE) is an extremely rare disease that affects mainly the young and more men than women. PHE are multicentric, locally aggressive, have low metastatic potential, and affect multiple tissue planes. Genetic aberrations are frequently detected in PHE and may play important roles in the occurrence, development, and treatment of this disease. In this study, we report a case of PHE with a novel SERPINE1-FOSB fusion gene. The fusion introduced a strong promoter near the coding region of FOSB, resulting in overexpression of intact FOSB. Immunohistochemical analysis showed overexpression of pAKT and mTOR in tumor cells, suggesting activation of the PI3K-AKT-mTOR signaling pathway. The patient responded well to targeted therapy with sirolimus, an mTOR inhibitor. Our study correlated dysregulation of a specific signaling pathway and the effectiveness of a targeted therapy to a specific genetic aberration. This information may be useful for future investigations of targeted therapeutics and provide a potential predictive biomarker for therapeutic effectiveness in PHE cases." @default.
• W3203788909 created "2021-10-11" @default.
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• W3203788909 date "2021-09-27" @default.
• W3203788909 modified "2023-09-30" @default.
• W3203788909 title "A novel <i>SERPINE1‐FOSB</i> fusion gene in pseudomyogenic hemangioendothelioma results in activation of intact FOSB and the PI3K‐AKT‐mTOR signaling pathway and responsiveness to sirolimus" @default.
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• W3203788909 doi "https://doi.org/10.1111/1346-8138.16158" @default.
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