Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203799993> ?p ?o ?g. }
- W3203799993 endingPage "26104" @default.
- W3203799993 startingPage "26096" @default.
- W3203799993 abstract "The ability of RNA to catalyze RNA ligation is critical to its central role in many prebiotic model scenarios, in particular the copying of information during self-replication. Prebiotically plausible ribozymes formed from short oligonucleotides can catalyze reversible RNA cleavage and ligation reactions, but harsh conditions or unusual scenarios are often required to promote folding and drive the reaction equilibrium towards ligation. Here, we demonstrate that ribozyme activity is greatly enhanced by charge-mediated phase separation with poly-L-lysine, which shifts the reaction equilibrium from cleavage in solution to ligation in peptide-RNA coaggregates and coacervates. This compartmentalization enables robust isothermal RNA assembly over a broad range of conditions, which can be leveraged to assemble long and complex RNAs from short fragments under mild conditions in the absence of exogenous activation chemistry, bridging the gap between pools of short oligomers and functional RNAs." @default.
- W3203799993 created "2021-10-11" @default.
- W3203799993 creator A5004907139 @default.
- W3203799993 creator A5013530580 @default.
- W3203799993 creator A5025965451 @default.
- W3203799993 creator A5026952715 @default.
- W3203799993 creator A5029192169 @default.
- W3203799993 date "2021-11-09" @default.
- W3203799993 modified "2023-10-13" @default.
- W3203799993 title "Enhanced Ribozyme‐Catalyzed Recombination and Oligonucleotide Assembly in Peptide‐RNA Condensates" @default.
- W3203799993 cites W1256551924 @default.
- W3203799993 cites W1481533238 @default.
- W3203799993 cites W1500111690 @default.
- W3203799993 cites W1528304359 @default.
- W3203799993 cites W1822130596 @default.
- W3203799993 cites W1968021894 @default.
- W3203799993 cites W1969387023 @default.
- W3203799993 cites W1970913359 @default.
- W3203799993 cites W1976186043 @default.
- W3203799993 cites W1980766416 @default.
- W3203799993 cites W1990942508 @default.
- W3203799993 cites W1993490997 @default.
- W3203799993 cites W2005229258 @default.
- W3203799993 cites W2010450809 @default.
- W3203799993 cites W2012273437 @default.
- W3203799993 cites W2015645971 @default.
- W3203799993 cites W2017457582 @default.
- W3203799993 cites W2030432943 @default.
- W3203799993 cites W2035118220 @default.
- W3203799993 cites W2037238732 @default.
- W3203799993 cites W2045263382 @default.
- W3203799993 cites W2046377044 @default.
- W3203799993 cites W2048565301 @default.
- W3203799993 cites W2050869467 @default.
- W3203799993 cites W2052918841 @default.
- W3203799993 cites W2054352933 @default.
- W3203799993 cites W2058627247 @default.
- W3203799993 cites W2062019095 @default.
- W3203799993 cites W2075152880 @default.
- W3203799993 cites W2080649605 @default.
- W3203799993 cites W2083313193 @default.
- W3203799993 cites W2089644153 @default.
- W3203799993 cites W2094354503 @default.
- W3203799993 cites W2097417489 @default.
- W3203799993 cites W2097924797 @default.
- W3203799993 cites W2119507875 @default.
- W3203799993 cites W2127447806 @default.
- W3203799993 cites W2127928013 @default.
- W3203799993 cites W2139066576 @default.
- W3203799993 cites W2139894458 @default.
- W3203799993 cites W2140268381 @default.
- W3203799993 cites W2140507333 @default.
- W3203799993 cites W2151179654 @default.
- W3203799993 cites W2155544170 @default.
- W3203799993 cites W2157877237 @default.
- W3203799993 cites W2164222049 @default.
- W3203799993 cites W2211953232 @default.
- W3203799993 cites W2273848551 @default.
- W3203799993 cites W2300135289 @default.
- W3203799993 cites W2408322376 @default.
- W3203799993 cites W2515842261 @default.
- W3203799993 cites W2593857818 @default.
- W3203799993 cites W2782626417 @default.
- W3203799993 cites W2785487547 @default.
- W3203799993 cites W2795610460 @default.
- W3203799993 cites W2795682970 @default.
- W3203799993 cites W2795718064 @default.
- W3203799993 cites W2807088576 @default.
- W3203799993 cites W2808121690 @default.
- W3203799993 cites W2901325372 @default.
- W3203799993 cites W2912127110 @default.
- W3203799993 cites W2923497684 @default.
- W3203799993 cites W2948933218 @default.
- W3203799993 cites W2954939440 @default.
- W3203799993 cites W2956904126 @default.
- W3203799993 cites W2964861802 @default.
- W3203799993 cites W2970079337 @default.
- W3203799993 cites W2978780344 @default.
- W3203799993 cites W3000568981 @default.
- W3203799993 cites W3026599087 @default.
- W3203799993 cites W3035911262 @default.
- W3203799993 cites W3039634568 @default.
- W3203799993 cites W3108439960 @default.
- W3203799993 cites W3128908375 @default.
- W3203799993 cites W3173273732 @default.
- W3203799993 cites W3203799993 @default.
- W3203799993 cites W4233629731 @default.
- W3203799993 doi "https://doi.org/10.1002/anie.202109267" @default.
- W3203799993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34569680" @default.
- W3203799993 hasPublicationYear "2021" @default.
- W3203799993 type Work @default.
- W3203799993 sameAs 3203799993 @default.
- W3203799993 citedByCount "21" @default.
- W3203799993 countsByYear W32037999932021 @default.
- W3203799993 countsByYear W32037999932022 @default.
- W3203799993 countsByYear W32037999932023 @default.
- W3203799993 crossrefType "journal-article" @default.
- W3203799993 hasAuthorship W3203799993A5004907139 @default.