Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203800863> ?p ?o ?g. }
- W3203800863 endingPage "7636" @default.
- W3203800863 startingPage "7623" @default.
- W3203800863 abstract "In the last decade, the inhibition of the mechanistic target of Rapamycin (mTOR) in renal clear cell carcinoma (RCC) has disappointed the clinician's expectations. Many clinical trials highlighted the low efficacy and unmanageable safety profile of first-generation mTOR inhibitors (Rapalogs), thus limiting their use in the clinical practice only to those patients who already failed several therapy lines. In this review, we analyze the major resistance mechanisms that undermine the efficacy of this class of drugs. Moreover, we describe some of the possible strategies to overcome the mechanisms of resistance and their clinical experimentation, with particular focus on novel mTOR inhibitors and the combinations of mTOR inhibitors and other anti-cancer drugs." @default.
- W3203800863 created "2021-10-11" @default.
- W3203800863 creator A5033356599 @default.
- W3203800863 creator A5035120623 @default.
- W3203800863 creator A5044527837 @default.
- W3203800863 creator A5048825591 @default.
- W3203800863 creator A5063457914 @default.
- W3203800863 creator A5090509109 @default.
- W3203800863 date "2021-10-01" @default.
- W3203800863 modified "2023-10-16" @default.
- W3203800863 title "Playing the Devil’s Advocate: Should We Give a Second Chance to mTOR Inhibition in Renal Clear Cell Carcinoma? – ie Strategies to Revert Resistance to mTOR Inhibitors" @default.
- W3203800863 cites W1967018540 @default.
- W3203800863 cites W1967237469 @default.
- W3203800863 cites W1967639975 @default.
- W3203800863 cites W1973234749 @default.
- W3203800863 cites W1982298098 @default.
- W3203800863 cites W1983698019 @default.
- W3203800863 cites W1984135992 @default.
- W3203800863 cites W1986683494 @default.
- W3203800863 cites W1987977871 @default.
- W3203800863 cites W1988609792 @default.
- W3203800863 cites W1997050190 @default.
- W3203800863 cites W1998476690 @default.
- W3203800863 cites W2004688803 @default.
- W3203800863 cites W2011817914 @default.
- W3203800863 cites W2013084027 @default.
- W3203800863 cites W2016398539 @default.
- W3203800863 cites W2020337923 @default.
- W3203800863 cites W2022201364 @default.
- W3203800863 cites W2029884231 @default.
- W3203800863 cites W2035029345 @default.
- W3203800863 cites W2035240798 @default.
- W3203800863 cites W2035521247 @default.
- W3203800863 cites W2036204029 @default.
- W3203800863 cites W2037716205 @default.
- W3203800863 cites W2042702043 @default.
- W3203800863 cites W2065592028 @default.
- W3203800863 cites W2071591166 @default.
- W3203800863 cites W2073622205 @default.
- W3203800863 cites W2080100938 @default.
- W3203800863 cites W2086524655 @default.
- W3203800863 cites W2093607033 @default.
- W3203800863 cites W2094242056 @default.
- W3203800863 cites W2094399892 @default.
- W3203800863 cites W2094667242 @default.
- W3203800863 cites W2101146511 @default.
- W3203800863 cites W2102648794 @default.
- W3203800863 cites W2104108149 @default.
- W3203800863 cites W2104241646 @default.
- W3203800863 cites W2108360575 @default.
- W3203800863 cites W2111577577 @default.
- W3203800863 cites W2113432343 @default.
- W3203800863 cites W2113505947 @default.
- W3203800863 cites W2115010775 @default.
- W3203800863 cites W2115966993 @default.
- W3203800863 cites W2118677643 @default.
- W3203800863 cites W2125544618 @default.
- W3203800863 cites W2126783165 @default.
- W3203800863 cites W2128925612 @default.
- W3203800863 cites W2134131507 @default.
- W3203800863 cites W2134138119 @default.
- W3203800863 cites W2136110110 @default.
- W3203800863 cites W2143585479 @default.
- W3203800863 cites W2146415848 @default.
- W3203800863 cites W2147718842 @default.
- W3203800863 cites W2148424438 @default.
- W3203800863 cites W2150595264 @default.
- W3203800863 cites W2153867442 @default.
- W3203800863 cites W2159871803 @default.
- W3203800863 cites W2168989003 @default.
- W3203800863 cites W2173523195 @default.
- W3203800863 cites W2233483325 @default.
- W3203800863 cites W2263864814 @default.
- W3203800863 cites W2294679176 @default.
- W3203800863 cites W2335012284 @default.
- W3203800863 cites W2388163742 @default.
- W3203800863 cites W2407198816 @default.
- W3203800863 cites W2412727495 @default.
- W3203800863 cites W2415950182 @default.
- W3203800863 cites W2522519290 @default.
- W3203800863 cites W2531001068 @default.
- W3203800863 cites W2557678736 @default.
- W3203800863 cites W2582388243 @default.
- W3203800863 cites W2757481782 @default.
- W3203800863 cites W2762427597 @default.
- W3203800863 cites W2909373683 @default.
- W3203800863 cites W2962684613 @default.
- W3203800863 cites W2981947702 @default.
- W3203800863 cites W3013877673 @default.
- W3203800863 cites W3014505556 @default.
- W3203800863 cites W3019726983 @default.
- W3203800863 cites W3020583382 @default.
- W3203800863 cites W3022746266 @default.
- W3203800863 cites W3031151503 @default.
- W3203800863 cites W3034465142 @default.
- W3203800863 cites W3041168567 @default.
- W3203800863 cites W3042347895 @default.
- W3203800863 cites W3084155739 @default.