FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203803312> ?p ?o ?g. }

• W3203803312 endingPage "17" @default.
• W3203803312 startingPage "1" @default.
• W3203803312 abstract "Aerobic training (AT) promotes several health benefits that may attenuate the progression of obesity associated diabetes. Since AT is an important nitric oxide (NO-) inducer mediating kidney-healthy phenotype, the present study is aimed at investigating the effects of AT on metabolic parameters, morphological, redox balance, inflammatory profile, and vasoactive peptides in the kidney of obese-diabetic Zucker rats receiving L-NAME (N(omega)-nitro-L-arginine methyl ester). Forty male Zucker rats (6 wk old) were assigned into four groups (n = 10, each): sedentary lean rats (CTL-Lean), sedentary obese rats (CTL-Obese), AT trained obese rats without blocking nitric oxide synthase (NOS) (Obese+AT), and obese-trained with NOS block (Obese+AT+L-NAME). AT groups ran 60 min in the maximal lactate steady state (MLSS), five days/wk/8 wk. Obese+AT rats improved glycemic homeostasis, SBP, aerobic capacity, renal mitochondria integrity, redox balance, inflammatory profile (e.g., TNF-α, CRP, IL-10, IL-4, and IL-17a), and molecules related to renal NO- metabolism (klotho/FGF23 axis, vasoactive peptides, renal histology, and reduced proteinuria). However, none of these positive outcomes were observed in CTL-Obese and Obese+AT+L-NAME (p < 0.0001) groups. Although Obese+AT+L-NAME lowered BP (compared with CTL-Obese; p < 0.0001), renal damage was observed after AT intervention. Furthermore, AT training under conditions of low NO- concentration increased signaling pathways associated with ACE-2/ANG1-7/MASr. We conclude that AT represents an important nonpharmacological intervention to improve kidney function in obese Zucker rats. However, these renal and metabolic benefits promoted by AT are dependent on NO- bioavailability and its underlying regulatory mechanisms." @default.
• W3203803312 created "2021-10-11" @default.
• W3203803312 creator A5004875326 @default.
• W3203803312 creator A5007776222 @default.
• W3203803312 creator A5009463499 @default.
• W3203803312 creator A5011731728 @default.
• W3203803312 creator A5021957345 @default.
• W3203803312 creator A5022892458 @default.
• W3203803312 creator A5024056945 @default.
• W3203803312 creator A5025309000 @default.
• W3203803312 creator A5035076304 @default.
• W3203803312 creator A5040299711 @default.
• W3203803312 creator A5042144636 @default.
• W3203803312 creator A5044264647 @default.
• W3203803312 creator A5044447982 @default.
• W3203803312 creator A5056929290 @default.
• W3203803312 creator A5072839114 @default.
• W3203803312 creator A5076213048 @default.
• W3203803312 creator A5076510238 @default.
• W3203803312 date "2021-09-28" @default.
• W3203803312 modified "2023-10-17" @default.
• W3203803312 title "Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats" @default.
• W3203803312 cites W132686822 @default.
• W3203803312 cites W1490541298 @default.
• W3203803312 cites W1508483953 @default.
• W3203803312 cites W1560721086 @default.
• W3203803312 cites W1586947032 @default.
• W3203803312 cites W1592232168 @default.
• W3203803312 cites W1597116068 @default.
• W3203803312 cites W1599948477 @default.
• W3203803312 cites W1933740832 @default.
• W3203803312 cites W1957149007 @default.
• W3203803312 cites W1973223262 @default.
• W3203803312 cites W1989012547 @default.
• W3203803312 cites W1997023449 @default.
• W3203803312 cites W2004580431 @default.
• W3203803312 cites W2005349781 @default.
• W3203803312 cites W2008714017 @default.
• W3203803312 cites W2009572885 @default.
• W3203803312 cites W2018822649 @default.
• W3203803312 cites W2025071203 @default.
• W3203803312 cites W2055194924 @default.
• W3203803312 cites W2055237834 @default.
• W3203803312 cites W2058114190 @default.
• W3203803312 cites W2058890881 @default.
• W3203803312 cites W2062390069 @default.
• W3203803312 cites W2067156215 @default.
• W3203803312 cites W2073555892 @default.
• W3203803312 cites W2090734822 @default.
• W3203803312 cites W2093902222 @default.
• W3203803312 cites W2097571046 @default.
• W3203803312 cites W2099027342 @default.
• W3203803312 cites W2101447446 @default.
• W3203803312 cites W2101705409 @default.
• W3203803312 cites W2103557717 @default.
• W3203803312 cites W2113798962 @default.
• W3203803312 cites W2115529543 @default.
• W3203803312 cites W2143274926 @default.
• W3203803312 cites W2143613076 @default.
• W3203803312 cites W2149868661 @default.
• W3203803312 cites W2150119335 @default.
• W3203803312 cites W2157192902 @default.
• W3203803312 cites W2157362634 @default.
• W3203803312 cites W2161110468 @default.
• W3203803312 cites W2177792834 @default.
• W3203803312 cites W2328849045 @default.
• W3203803312 cites W2339316188 @default.
• W3203803312 cites W2415080161 @default.
• W3203803312 cites W2415587673 @default.
• W3203803312 cites W2416243378 @default.
• W3203803312 cites W2504372097 @default.
• W3203803312 cites W2508176424 @default.
• W3203803312 cites W2558092447 @default.
• W3203803312 cites W2560781586 @default.
• W3203803312 cites W2581409872 @default.
• W3203803312 cites W2582735211 @default.
• W3203803312 cites W2588796731 @default.
• W3203803312 cites W2605134202 @default.
• W3203803312 cites W2625136688 @default.
• W3203803312 cites W2775650155 @default.
• W3203803312 cites W2781610106 @default.
• W3203803312 cites W2811201605 @default.
• W3203803312 cites W2895132838 @default.
• W3203803312 cites W2901846697 @default.
• W3203803312 cites W2912458986 @default.
• W3203803312 cites W2913391623 @default.
• W3203803312 cites W2948290726 @default.
• W3203803312 cites W2951268956 @default.
• W3203803312 cites W2974342528 @default.
• W3203803312 cites W3010370692 @default.
• W3203803312 cites W3012354264 @default.
• W3203803312 cites W3016677710 @default.
• W3203803312 cites W3017566260 @default.
• W3203803312 cites W3036657571 @default.
• W3203803312 cites W3049418459 @default.
• W3203803312 cites W4251696086 @default.
• W3203803312 cites W4253545088 @default.
• W3203803312 cites W4294216491 @default.

• next