Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203835109> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3203835109 endingPage "e001737" @default.
- W3203835109 startingPage "e001737" @default.
- W3203835109 abstract "In the past, the human microbiome has consistently been associated with rheumatoid arthritis (RA) and disease activity. Here, we investigate the antimicrobial activity of disease-modifying antirheumatic drugs (DMARDs) against typical representatives of the oral microflora that have been associated with RA.DMARDs were screened for antimicrobial activity against bacteria that are associated with the pathogenesis of the disease and/or frequently isolated from the oral microflora of patients with RA. Screening was done by an agar diffusion assay and minimum inhibitory concentrations (MICs) of antimicrobial active substances were then determined by broth dilution.Aurothiomalate and sulfasalazine demonstrated broad-spectrum antimicrobial activity, but with MICs ranging from 18 to >280 µg/mL and 150 to >600 µg/mL, respectively, only at supratherapeutic concentrations. Methotrexate showed antimicrobial activity only against Fusobacterium nucleatum and Viridans streptococci. The corresponding MICs were 3.75 to >30 µg/mL and 0.5-15 µg/mL, respectively, thus at least for streptococci, within the therapeutically achievable range. No other DMARD tested showed antimicrobial activity in the agar diffusion screening assay.Methotrexate, sulfasalazine and aurothiomalate showed antimicrobial activity against a broad spectrum of RA associated pathogens of the oral microflora. While methotrexate showed relevant antimicrobial activity, and to a more limited extent aurothiomalate, sulfasalazine was active only at far supratherapeutic systemic concentrations. Nevertheless, given the highly species-dependent antimicrobial activity and the multiple ways it can affect the human microbiome, our results suggest a link between antimicrobially active antirheumatic drugs and their potential effect in the treatment of RA." @default.
- W3203835109 created "2021-10-11" @default.
- W3203835109 creator A5020269627 @default.
- W3203835109 creator A5022908268 @default.
- W3203835109 creator A5047517354 @default.
- W3203835109 creator A5061411814 @default.
- W3203835109 creator A5075783414 @default.
- W3203835109 date "2021-09-01" @default.
- W3203835109 modified "2023-09-26" @default.
- W3203835109 title "In vitro evaluation of disease-modifying antirheumatic drugs against rheumatoid arthritis associated pathogens of the oral microflora" @default.
- W3203835109 cites W1590947834 @default.
- W3203835109 cites W1971349339 @default.
- W3203835109 cites W2011231650 @default.
- W3203835109 cites W2038948330 @default.
- W3203835109 cites W2043925718 @default.
- W3203835109 cites W2061067592 @default.
- W3203835109 cites W2113552312 @default.
- W3203835109 cites W2128980514 @default.
- W3203835109 cites W2169364567 @default.
- W3203835109 cites W2463118776 @default.
- W3203835109 cites W2549273024 @default.
- W3203835109 cites W2556999435 @default.
- W3203835109 cites W2792021903 @default.
- W3203835109 cites W2857965825 @default.
- W3203835109 cites W2890131570 @default.
- W3203835109 cites W2898577183 @default.
- W3203835109 cites W2950245396 @default.
- W3203835109 cites W2966245763 @default.
- W3203835109 cites W3013024294 @default.
- W3203835109 cites W3119807729 @default.
- W3203835109 cites W50618910 @default.
- W3203835109 doi "https://doi.org/10.1136/rmdopen-2021-001737" @default.
- W3203835109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8483044" @default.
- W3203835109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34588273" @default.
- W3203835109 hasPublicationYear "2021" @default.
- W3203835109 type Work @default.
- W3203835109 sameAs 3203835109 @default.
- W3203835109 citedByCount "4" @default.
- W3203835109 countsByYear W32038351092021 @default.
- W3203835109 countsByYear W32038351092022 @default.
- W3203835109 crossrefType "journal-article" @default.
- W3203835109 hasAuthorship W3203835109A5020269627 @default.
- W3203835109 hasAuthorship W3203835109A5022908268 @default.
- W3203835109 hasAuthorship W3203835109A5047517354 @default.
- W3203835109 hasAuthorship W3203835109A5061411814 @default.
- W3203835109 hasAuthorship W3203835109A5075783414 @default.
- W3203835109 hasBestOaLocation W32038351091 @default.
- W3203835109 hasConcept C126322002 @default.
- W3203835109 hasConcept C2777077863 @default.
- W3203835109 hasConcept C2777575956 @default.
- W3203835109 hasConcept C2779134260 @default.
- W3203835109 hasConcept C2779383735 @default.
- W3203835109 hasConcept C2780479503 @default.
- W3203835109 hasConcept C4937899 @default.
- W3203835109 hasConcept C71924100 @default.
- W3203835109 hasConcept C86803240 @default.
- W3203835109 hasConcept C89423630 @default.
- W3203835109 hasConcept C98274493 @default.
- W3203835109 hasConceptScore W3203835109C126322002 @default.
- W3203835109 hasConceptScore W3203835109C2777077863 @default.
- W3203835109 hasConceptScore W3203835109C2777575956 @default.
- W3203835109 hasConceptScore W3203835109C2779134260 @default.
- W3203835109 hasConceptScore W3203835109C2779383735 @default.
- W3203835109 hasConceptScore W3203835109C2780479503 @default.
- W3203835109 hasConceptScore W3203835109C4937899 @default.
- W3203835109 hasConceptScore W3203835109C71924100 @default.
- W3203835109 hasConceptScore W3203835109C86803240 @default.
- W3203835109 hasConceptScore W3203835109C89423630 @default.
- W3203835109 hasConceptScore W3203835109C98274493 @default.
- W3203835109 hasIssue "3" @default.
- W3203835109 hasLocation W32038351091 @default.
- W3203835109 hasLocation W32038351092 @default.
- W3203835109 hasLocation W32038351093 @default.
- W3203835109 hasLocation W32038351094 @default.
- W3203835109 hasLocation W32038351095 @default.
- W3203835109 hasOpenAccess W3203835109 @default.
- W3203835109 hasPrimaryLocation W32038351091 @default.
- W3203835109 hasRelatedWork W2156283049 @default.
- W3203835109 hasRelatedWork W2316954211 @default.
- W3203835109 hasRelatedWork W2352294526 @default.
- W3203835109 hasRelatedWork W2427452099 @default.
- W3203835109 hasRelatedWork W2602481810 @default.
- W3203835109 hasRelatedWork W2761967325 @default.
- W3203835109 hasRelatedWork W2911506796 @default.
- W3203835109 hasRelatedWork W4200327140 @default.
- W3203835109 hasRelatedWork W4245782456 @default.
- W3203835109 hasRelatedWork W4286779822 @default.
- W3203835109 hasVolume "7" @default.
- W3203835109 isParatext "false" @default.
- W3203835109 isRetracted "false" @default.
- W3203835109 magId "3203835109" @default.
- W3203835109 workType "article" @default.