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- W3203841708 endingPage "4969" @default.
- W3203841708 startingPage "4969" @default.
- W3203841708 abstract "Cancer is a group of heterogeneous diseases that results from the occurrence of genetic alterations combined with epigenetic changes and environmental stimuli that increase cancer cell plasticity. Indeed, multiple cancer cell populations coexist within the same tumour, favouring cancer progression and metastatic dissemination as well as drug resistance, thereby representing a major obstacle for treatment. Epigenetic changes contribute to the onset of intra-tumour heterogeneity (ITH) as they facilitate cell adaptation to perturbation of the tumour microenvironment. Despite being its central role, the intrinsic multi-layered and reversible epigenetic pattern limits the possibility to uniquely determine its contribution to ITH. In this review, we first describe the major epigenetic mechanisms involved in tumourigenesis and then discuss how single-cell-based approaches contribute to dissecting the key role of epigenetic changes in tumour heterogeneity. Furthermore, we highlight the importance of dissecting the interplay between genetics, epigenetics, and tumour microenvironments to decipher the molecular mechanisms governing tumour progression and drug resistance." @default.
- W3203841708 created "2021-10-11" @default.
- W3203841708 creator A5003436777 @default.
- W3203841708 creator A5060882767 @default.
- W3203841708 creator A5071725155 @default.
- W3203841708 date "2021-10-03" @default.
- W3203841708 modified "2023-10-18" @default.
- W3203841708 title "An Epigenetic Perspective on Intra-Tumour Heterogeneity: Novel Insights and New Challenges from Multiple Fields" @default.
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