FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203865068> ?p ?o ?g. }

• W3203865068 abstract "The well-known issue of reconstructing regulatory networks from gene expression measurements has been somewhat disrupted by the emergence and rapid development of single-cell data. Indeed, the traditional way of seeing a gene regulatory network as a deterministic system affected by small noise is being challenged by the highly stochastic, bursty nature of gene expression revealed at single-cell level. In previous work, we described a promising strategy in which network inference is seen as a calibration procedure for a mechanistic model driven by transcriptional bursting: this model inherently captures the typical variability of single-cell data without requiring ad hoc external noise, unlike ordinary or even stochastic differential equations often used in this context. The resulting algorithm, based on approximate resolution of the related master equation using a self-consistent field, was derived in detail but only applied as a proof of concept to simulated two-gene networks. Here we derive a simplified version of the algorithm and apply it, in more relevant situations, to both simulated and real single-cell RNA-Seq data. We point out three interesting features of this approach: it is computationally tractable with realistic numbers of cells and genes, it provides inferred networks with biological interpretability, and the underlying mechanistic model allows testable predictions to be made. A practical implementation of the inference procedure, together with an efficient stochastic simulation algorithm for the model, is available as a Python package." @default.
• W3203865068 created "2021-10-11" @default.
• W3203865068 creator A5031719309 @default.
• W3203865068 date "2021-10-07" @default.
• W3203865068 modified "2023-09-26" @default.
• W3203865068 title "Gene regulatory network inference from single-cell data using a self-consistent proteomic field" @default.
• W3203865068 cites W1847626991 @default.
• W3203865068 cites W1906471536 @default.
• W3203865068 cites W1963522244 @default.
• W3203865068 cites W1976714996 @default.
• W3203865068 cites W1976752968 @default.
• W3203865068 cites W1987109029 @default.
• W3203865068 cites W2000534401 @default.
• W3203865068 cites W2002919709 @default.
• W3203865068 cites W2003470745 @default.
• W3203865068 cites W2015538881 @default.
• W3203865068 cites W2023142470 @default.
• W3203865068 cites W2056556558 @default.
• W3203865068 cites W2065326904 @default.
• W3203865068 cites W2068751516 @default.
• W3203865068 cites W2070459069 @default.
• W3203865068 cites W2076513103 @default.
• W3203865068 cites W2091198609 @default.
• W3203865068 cites W2096705138 @default.
• W3203865068 cites W2098276914 @default.
• W3203865068 cites W2105512180 @default.
• W3203865068 cites W2115368299 @default.
• W3203865068 cites W2125258701 @default.
• W3203865068 cites W2127403997 @default.
• W3203865068 cites W2128551987 @default.
• W3203865068 cites W2131025197 @default.
• W3203865068 cites W2136453810 @default.
• W3203865068 cites W2140855217 @default.
• W3203865068 cites W2141688036 @default.
• W3203865068 cites W2145748272 @default.
• W3203865068 cites W2149242848 @default.
• W3203865068 cites W2299194411 @default.
• W3203865068 cites W2307634823 @default.
• W3203865068 cites W2398184959 @default.
• W3203865068 cites W2491614679 @default.
• W3203865068 cites W2518828632 @default.
• W3203865068 cites W2560424365 @default.
• W3203865068 cites W2570629027 @default.
• W3203865068 cites W2598638843 @default.
• W3203865068 cites W2612568060 @default.
• W3203865068 cites W2616922646 @default.
• W3203865068 cites W2757234574 @default.
• W3203865068 cites W2760415787 @default.
• W3203865068 cites W2795460076 @default.
• W3203865068 cites W2802291136 @default.
• W3203865068 cites W2804500674 @default.
• W3203865068 cites W2808316845 @default.
• W3203865068 cites W2808743742 @default.
• W3203865068 cites W28766783 @default.
• W3203865068 cites W2888009468 @default.
• W3203865068 cites W2900088947 @default.
• W3203865068 cites W2908300237 @default.
• W3203865068 cites W2921706614 @default.
• W3203865068 cites W2946478090 @default.
• W3203865068 cites W2949237386 @default.
• W3203865068 cites W2950647373 @default.
• W3203865068 cites W2951850020 @default.
• W3203865068 cites W2952938648 @default.
• W3203865068 cites W2963497144 @default.
• W3203865068 cites W2990357870 @default.
• W3203865068 cites W2997831639 @default.
• W3203865068 cites W3010569643 @default.
• W3203865068 cites W3016251883 @default.
• W3203865068 cites W3024161231 @default.
• W3203865068 cites W3083031034 @default.
• W3203865068 cites W3093153369 @default.
• W3203865068 cites W3097995899 @default.
• W3203865068 cites W3105373037 @default.
• W3203865068 cites W3164156820 @default.
• W3203865068 hasPublicationYear "2021" @default.
• W3203865068 type Work @default.
• W3203865068 sameAs 3203865068 @default.
• W3203865068 citedByCount "0" @default.
• W3203865068 crossrefType "posted-content" @default.
• W3203865068 hasAuthorship W3203865068A5031719309 @default.
• W3203865068 hasBestOaLocation W32038650683 @default.
• W3203865068 hasConcept C104317684 @default.
• W3203865068 hasConcept C124101348 @default.
• W3203865068 hasConcept C150194340 @default.
• W3203865068 hasConcept C154945302 @default.
• W3203865068 hasConcept C202444582 @default.
• W3203865068 hasConcept C2776214188 @default.
• W3203865068 hasConcept C33923547 @default.
• W3203865068 hasConcept C41008148 @default.
• W3203865068 hasConcept C54355233 @default.
• W3203865068 hasConcept C67339327 @default.
• W3203865068 hasConcept C70721500 @default.
• W3203865068 hasConcept C86803240 @default.
• W3203865068 hasConcept C9652623 @default.
• W3203865068 hasConceptScore W3203865068C104317684 @default.
• W3203865068 hasConceptScore W3203865068C124101348 @default.
• W3203865068 hasConceptScore W3203865068C150194340 @default.
• W3203865068 hasConceptScore W3203865068C154945302 @default.
• W3203865068 hasConceptScore W3203865068C202444582 @default.
• W3203865068 hasConceptScore W3203865068C2776214188 @default.

• next