FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203894077> ?p ?o ?g. }

• W3203894077 endingPage "5973" @default.
• W3203894077 startingPage "5973" @default.
• W3203894077 abstract "Immunotherapy harnessing immune functions is a promising strategy for cancer treatment. Tumor sensitization is one approach to enhance tumor cell susceptibility to immune cell cytotoxicity that can be used in combination with immunotherapy to achieve therapeutic efficiency. Cordycepin, a bioactive compound that can be extracted from some Cordyceps spp. has been reported to effectively inhibit tumor growth, however, the mechanism of its tumor sensitization activity that enhances immune cell cytotoxicity is unknown. In the present study, we investigated the potency of cordycepin to sensitize a lethal cancer, cholangiocarcinoma (CCA), to natural killer (NK) cells. Treatment with cordycepin prior to and during co-culturing with NK-92 cells significantly increased cell death of KKU-213A as compared to solitary cordycepin or NK treatment. Moreover, sensitization activity was also observed in the combination of NK-92 cells and Cordyceps militaris extract that contained cordycepin as a major component. The cordycepin treatment remarkably caused an increase in TRAIL receptor (DR4 and DR5) expression in KKU-213A, suggesting the possible involvement of TRAIL signaling in KKU-213A sensitization to NK-92 cells. In conclusion, this is the first report on the sensitization activity of cordycepin on CCA cells to NK cytotoxicity, which supports that cordycepin can be further developed as an alternate immunomodulating agent." @default.
• W3203894077 created "2021-10-11" @default.
• W3203894077 creator A5009328108 @default.
• W3203894077 creator A5010167985 @default.
• W3203894077 creator A5028097176 @default.
• W3203894077 creator A5029697055 @default.
• W3203894077 creator A5032734281 @default.
• W3203894077 creator A5047429928 @default.
• W3203894077 creator A5065338803 @default.
• W3203894077 date "2021-10-01" @default.
• W3203894077 modified "2023-10-03" @default.
• W3203894077 title "Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells" @default.
• W3203894077 cites W1971873029 @default.
• W3203894077 cites W1977087426 @default.
• W3203894077 cites W1977623079 @default.
• W3203894077 cites W1987370132 @default.
• W3203894077 cites W2000002383 @default.
• W3203894077 cites W2012369608 @default.
• W3203894077 cites W2030612376 @default.
• W3203894077 cites W2037804015 @default.
• W3203894077 cites W2043555706 @default.
• W3203894077 cites W2046634887 @default.
• W3203894077 cites W2051520080 @default.
• W3203894077 cites W2057067795 @default.
• W3203894077 cites W2085717357 @default.
• W3203894077 cites W2088079051 @default.
• W3203894077 cites W2114073677 @default.
• W3203894077 cites W2134454138 @default.
• W3203894077 cites W2142323794 @default.
• W3203894077 cites W2149634794 @default.
• W3203894077 cites W2164849772 @default.
• W3203894077 cites W2171212437 @default.
• W3203894077 cites W2472016897 @default.
• W3203894077 cites W2618024365 @default.
• W3203894077 cites W2735011415 @default.
• W3203894077 cites W2753081026 @default.
• W3203894077 cites W2756437536 @default.
• W3203894077 cites W2763492611 @default.
• W3203894077 cites W2765263172 @default.
• W3203894077 cites W2773826734 @default.
• W3203894077 cites W2794808923 @default.
• W3203894077 cites W2804044064 @default.
• W3203894077 cites W2894625088 @default.
• W3203894077 cites W2904483435 @default.
• W3203894077 cites W2910701797 @default.
• W3203894077 cites W2911867856 @default.
• W3203894077 cites W2920849174 @default.
• W3203894077 cites W2938923420 @default.
• W3203894077 cites W2976602887 @default.
• W3203894077 cites W3002630984 @default.
• W3203894077 cites W3006730221 @default.
• W3203894077 cites W3009880690 @default.
• W3203894077 cites W3012732786 @default.
• W3203894077 cites W3016280944 @default.
• W3203894077 cites W3080144325 @default.
• W3203894077 cites W3083127474 @default.
• W3203894077 cites W3091822333 @default.
• W3203894077 cites W3107923931 @default.
• W3203894077 cites W3117356788 @default.
• W3203894077 cites W3120414804 @default.
• W3203894077 cites W4237107236 @default.
• W3203894077 cites W61107372 @default.
• W3203894077 doi "https://doi.org/10.3390/molecules26195973" @default.
• W3203894077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8512070" @default.
• W3203894077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34641520" @default.
• W3203894077 hasPublicationYear "2021" @default.
• W3203894077 type Work @default.
• W3203894077 sameAs 3203894077 @default.
• W3203894077 citedByCount "7" @default.
• W3203894077 countsByYear W32038940772022 @default.
• W3203894077 countsByYear W32038940772023 @default.
• W3203894077 crossrefType "journal-article" @default.
• W3203894077 hasAuthorship W3203894077A5009328108 @default.
• W3203894077 hasAuthorship W3203894077A5010167985 @default.
• W3203894077 hasAuthorship W3203894077A5028097176 @default.
• W3203894077 hasAuthorship W3203894077A5029697055 @default.
• W3203894077 hasAuthorship W3203894077A5032734281 @default.
• W3203894077 hasAuthorship W3203894077A5047429928 @default.
• W3203894077 hasAuthorship W3203894077A5065338803 @default.
• W3203894077 hasBestOaLocation W32038940771 @default.
• W3203894077 hasConcept C109316439 @default.
• W3203894077 hasConcept C121608353 @default.
• W3203894077 hasConcept C126322002 @default.
• W3203894077 hasConcept C185592680 @default.
• W3203894077 hasConcept C202751555 @default.
• W3203894077 hasConcept C203014093 @default.
• W3203894077 hasConcept C2776217527 @default.
• W3203894077 hasConcept C2776801289 @default.
• W3203894077 hasConcept C2777701055 @default.
• W3203894077 hasConcept C2778102761 @default.
• W3203894077 hasConcept C2779085617 @default.
• W3203894077 hasConcept C2780066241 @default.
• W3203894077 hasConcept C2780674031 @default.
• W3203894077 hasConcept C502942594 @default.
• W3203894077 hasConcept C55493867 @default.
• W3203894077 hasConcept C556039675 @default.
• W3203894077 hasConcept C71924100 @default.
• W3203894077 hasConcept C86803240 @default.

• next