Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203916574> ?p ?o ?g. }
- W3203916574 abstract "The role of human prostatic acid phosphatase (PAcP, P15309|PPAP_HUMAN) in prostate cancer was investigated using a new proteomics tool termed signal sequence swapping (replacement of domains from the native cleaved amino terminal signal sequence of secretory/membrane proteins with corresponding regions of functionally distinct signal sequence subtypes). This manipulation preferentially redirects proteins to different pathways of biogenesis at the endoplasmic reticulum (ER), magnifying normally difficult to detect subsets of the protein of interest. For PAcP, this technique reveals three forms identical in amino acid sequence but profoundly different in physiological functions, subcellular location, and biochemical properties. These three forms of PAcP can also occur with the wildtype PAcP signal sequence. Clinical specimens from patients with prostate cancer demonstrate that one form, termed PLPAcP, correlates with early prostate cancer. These findings confirm the analytical power of this method, implicate PLPAcP in prostate cancer pathogenesis, and suggest novel anticancer therapeutic strategies." @default.
- W3203916574 created "2021-10-11" @default.
- W3203916574 creator A5005017303 @default.
- W3203916574 creator A5009792539 @default.
- W3203916574 creator A5026534555 @default.
- W3203916574 creator A5027633975 @default.
- W3203916574 creator A5028232112 @default.
- W3203916574 creator A5037677777 @default.
- W3203916574 creator A5040951895 @default.
- W3203916574 creator A5045185269 @default.
- W3203916574 creator A5050472899 @default.
- W3203916574 creator A5060659919 @default.
- W3203916574 creator A5066247177 @default.
- W3203916574 date "2021-10-01" @default.
- W3203916574 modified "2023-10-16" @default.
- W3203916574 title "Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis" @default.
- W3203916574 cites W1484115349 @default.
- W3203916574 cites W1504179388 @default.
- W3203916574 cites W1561829393 @default.
- W3203916574 cites W1578535367 @default.
- W3203916574 cites W1644854647 @default.
- W3203916574 cites W1961818598 @default.
- W3203916574 cites W1986522582 @default.
- W3203916574 cites W1992327650 @default.
- W3203916574 cites W1992985137 @default.
- W3203916574 cites W2000400362 @default.
- W3203916574 cites W2020258831 @default.
- W3203916574 cites W2025576517 @default.
- W3203916574 cites W2030800943 @default.
- W3203916574 cites W2033507378 @default.
- W3203916574 cites W2033633291 @default.
- W3203916574 cites W2057267036 @default.
- W3203916574 cites W2060334902 @default.
- W3203916574 cites W2062440930 @default.
- W3203916574 cites W2080894816 @default.
- W3203916574 cites W2089216636 @default.
- W3203916574 cites W2097585139 @default.
- W3203916574 cites W2100444545 @default.
- W3203916574 cites W2104418929 @default.
- W3203916574 cites W2111932011 @default.
- W3203916574 cites W2121948931 @default.
- W3203916574 cites W2140731089 @default.
- W3203916574 cites W2147415439 @default.
- W3203916574 cites W2147987325 @default.
- W3203916574 cites W2149880971 @default.
- W3203916574 cites W2160427174 @default.
- W3203916574 cites W2162824898 @default.
- W3203916574 cites W2165854061 @default.
- W3203916574 cites W2166271237 @default.
- W3203916574 cites W2171147265 @default.
- W3203916574 cites W2219817965 @default.
- W3203916574 cites W2315084821 @default.
- W3203916574 cites W2320550039 @default.
- W3203916574 cites W2739230262 @default.
- W3203916574 cites W2945996148 @default.
- W3203916574 cites W2981216777 @default.
- W3203916574 cites W2989835126 @default.
- W3203916574 cites W3013510586 @default.
- W3203916574 cites W4232547688 @default.
- W3203916574 cites W4293247451 @default.
- W3203916574 cites W996384282 @default.
- W3203916574 doi "https://doi.org/10.1042/bsr20211646" @default.
- W3203916574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8536833" @default.
- W3203916574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34677582" @default.
- W3203916574 hasPublicationYear "2021" @default.
- W3203916574 type Work @default.
- W3203916574 sameAs 3203916574 @default.
- W3203916574 citedByCount "7" @default.
- W3203916574 countsByYear W32039165742022 @default.
- W3203916574 countsByYear W32039165742023 @default.
- W3203916574 crossrefType "journal-article" @default.
- W3203916574 hasAuthorship W3203916574A5005017303 @default.
- W3203916574 hasAuthorship W3203916574A5009792539 @default.
- W3203916574 hasAuthorship W3203916574A5026534555 @default.
- W3203916574 hasAuthorship W3203916574A5027633975 @default.
- W3203916574 hasAuthorship W3203916574A5028232112 @default.
- W3203916574 hasAuthorship W3203916574A5037677777 @default.
- W3203916574 hasAuthorship W3203916574A5040951895 @default.
- W3203916574 hasAuthorship W3203916574A5045185269 @default.
- W3203916574 hasAuthorship W3203916574A5050472899 @default.
- W3203916574 hasAuthorship W3203916574A5060659919 @default.
- W3203916574 hasAuthorship W3203916574A5066247177 @default.
- W3203916574 hasBestOaLocation W32039165741 @default.
- W3203916574 hasConcept C104317684 @default.
- W3203916574 hasConcept C10858879 @default.
- W3203916574 hasConcept C121608353 @default.
- W3203916574 hasConcept C131934819 @default.
- W3203916574 hasConcept C158617107 @default.
- W3203916574 hasConcept C167625842 @default.
- W3203916574 hasConcept C203014093 @default.
- W3203916574 hasConcept C2776235491 @default.
- W3203916574 hasConcept C2776490512 @default.
- W3203916574 hasConcept C2778112365 @default.
- W3203916574 hasConcept C2780192828 @default.
- W3203916574 hasConcept C2780942790 @default.
- W3203916574 hasConcept C502942594 @default.
- W3203916574 hasConcept C515207424 @default.
- W3203916574 hasConcept C54355233 @default.
- W3203916574 hasConcept C55493867 @default.
- W3203916574 hasConcept C70721500 @default.