FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203923199> ?p ?o ?g. }

• W3203923199 endingPage "104779" @default.
• W3203923199 startingPage "104779" @default.
• W3203923199 abstract "• A new mutant strain L. casei JY300-8 with excellent probiotic performance was generated by heavy ion beams irradiation induced-mutagenesis. • Probiotics JY300-8 was used for treat colon cancer and have a remarkable therapeutic effect in colon cancer mice. • JY300-8 was of better therapeutic effects, low treatment cost and less side effects compared to first-line therapy drug for cancer (DFUR) at an early state of colon cancer in mice. • JY300-8 significantly inhibited tumor progression by activating apoptosis of colon cells and regulating the gut microbiota in colon cancer mice. Probiotics, as novel functional foods via microbiota-modulation to enhance host health and inhibit tumor carcinogenesis, have been attracted considerable interests. L. casei JY, as a potential probiotic, was irradiated by 12 C 6+ beams and a new mutant strain JY300-8 was generated through three round selections of transit tolerance in the upper human gastrointestinal tract, adhesion ability to Caco-2 cells and inhibitory pathogenic microorganisms, respectively. Interestingly, JY300-8 presented excellent properties, including the strongest adhesion ability (86.81%) to Caco-2 cells to our knowledge and more excellent antimicrobial properties, which was used for the potential candidate probiotic. Additionally, JY300-8 could significantly inhibit the proliferation of Caco-2, HT29 and HCT116 cells in vitro, respectively. Furthermore, there were better therapeutic effects at an early stage in colon cancer mice, which included the similar survival rates (90%) and stronger inhibitory effect on tumor (83.48%), lower treatment cost and less side effects in comparison to the therapy drug (DFUR) for colon cancer (65.65%), which was attributed to promoting the apoptosis of colon cells and enhancing antitumor response via modulation cancer-induced gut microbiota dysbiosis by oral administration of JY300-8. Therefore, JY300-8 has great potential for bio-prophylactic and bio-therapeutic functional food in colon carcinogenesis. This work provided a promising approach that could improve human health, reduce greatly cancer incidence and mitigate cancer progression via modulation gut microbiota by excellent probiotics intervention." @default.
• W3203923199 created "2021-10-11" @default.
• W3203923199 creator A5012541925 @default.
• W3203923199 creator A5014729654 @default.
• W3203923199 creator A5025065042 @default.
• W3203923199 creator A5033786916 @default.
• W3203923199 creator A5060706512 @default.
• W3203923199 creator A5070781796 @default.
• W3203923199 creator A5080534131 @default.
• W3203923199 date "2021-12-01" @default.
• W3203923199 modified "2023-10-14" @default.
• W3203923199 title "Lactobacillus casei JY300-8 generated by 12C6+ beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice" @default.
• W3203923199 cites W1607743621 @default.
• W3203923199 cites W1637484268 @default.
• W3203923199 cites W1965554634 @default.
• W3203923199 cites W1971463658 @default.
• W3203923199 cites W1976631815 @default.
• W3203923199 cites W1979903841 @default.
• W3203923199 cites W1981136755 @default.
• W3203923199 cites W1990162928 @default.
• W3203923199 cites W2005152602 @default.
• W3203923199 cites W2016536572 @default.
• W3203923199 cites W2075165542 @default.
• W3203923199 cites W2075871207 @default.
• W3203923199 cites W2077941682 @default.
• W3203923199 cites W2081024145 @default.
• W3203923199 cites W2114151609 @default.
• W3203923199 cites W2118867584 @default.
• W3203923199 cites W2130392703 @default.
• W3203923199 cites W2133273689 @default.
• W3203923199 cites W2135436012 @default.
• W3203923199 cites W2135907703 @default.
• W3203923199 cites W2163916914 @default.
• W3203923199 cites W2185075416 @default.
• W3203923199 cites W2263582754 @default.
• W3203923199 cites W2322458311 @default.
• W3203923199 cites W2335552289 @default.
• W3203923199 cites W2342898642 @default.
• W3203923199 cites W2346149192 @default.
• W3203923199 cites W2557869625 @default.
• W3203923199 cites W2574508044 @default.
• W3203923199 cites W2575763462 @default.
• W3203923199 cites W2616962711 @default.
• W3203923199 cites W2617691583 @default.
• W3203923199 cites W2735740095 @default.
• W3203923199 cites W2749062743 @default.
• W3203923199 cites W2765092509 @default.
• W3203923199 cites W2765650037 @default.
• W3203923199 cites W2773797685 @default.
• W3203923199 cites W2783139321 @default.
• W3203923199 cites W2794202050 @default.
• W3203923199 cites W2795302724 @default.
• W3203923199 cites W2800827125 @default.
• W3203923199 cites W2887311793 @default.
• W3203923199 cites W2913383176 @default.
• W3203923199 cites W2921830965 @default.
• W3203923199 cites W2939413421 @default.
• W3203923199 cites W2949806763 @default.
• W3203923199 cites W3118401285 @default.
• W3203923199 cites W965800138 @default.
• W3203923199 doi "https://doi.org/10.1016/j.jff.2021.104779" @default.
• W3203923199 hasPublicationYear "2021" @default.
• W3203923199 type Work @default.
• W3203923199 sameAs 3203923199 @default.
• W3203923199 citedByCount "6" @default.
• W3203923199 countsByYear W32039231992022 @default.
• W3203923199 countsByYear W32039231992023 @default.
• W3203923199 crossrefType "journal-article" @default.
• W3203923199 hasAuthorship W3203923199A5012541925 @default.
• W3203923199 hasAuthorship W3203923199A5014729654 @default.
• W3203923199 hasAuthorship W3203923199A5025065042 @default.
• W3203923199 hasAuthorship W3203923199A5033786916 @default.
• W3203923199 hasAuthorship W3203923199A5060706512 @default.
• W3203923199 hasAuthorship W3203923199A5070781796 @default.
• W3203923199 hasAuthorship W3203923199A5080534131 @default.
• W3203923199 hasBestOaLocation W32039231991 @default.
• W3203923199 hasConcept C104317684 @default.
• W3203923199 hasConcept C121608353 @default.
• W3203923199 hasConcept C16318435 @default.
• W3203923199 hasConcept C185592680 @default.
• W3203923199 hasConcept C2776662696 @default.
• W3203923199 hasConcept C2779256057 @default.
• W3203923199 hasConcept C2780206646 @default.
• W3203923199 hasConcept C501734568 @default.
• W3203923199 hasConcept C523546767 @default.
• W3203923199 hasConcept C539455810 @default.
• W3203923199 hasConcept C54355233 @default.
• W3203923199 hasConcept C55493867 @default.
• W3203923199 hasConcept C86803240 @default.
• W3203923199 hasConcept C89423630 @default.
• W3203923199 hasConceptScore W3203923199C104317684 @default.
• W3203923199 hasConceptScore W3203923199C121608353 @default.
• W3203923199 hasConceptScore W3203923199C16318435 @default.
• W3203923199 hasConceptScore W3203923199C185592680 @default.
• W3203923199 hasConceptScore W3203923199C2776662696 @default.
• W3203923199 hasConceptScore W3203923199C2779256057 @default.
• W3203923199 hasConceptScore W3203923199C2780206646 @default.
• W3203923199 hasConceptScore W3203923199C501734568 @default.

• next