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• W3203934650 endingPage "141" @default.
• W3203934650 startingPage "125" @default.
• W3203934650 abstract "Maintaining cellular homeostasis, optimal cell function, and healthy organelles are key factors that enable a prompt response to any stressful condition that may arise throughout the life of an individual. Autophagy is a catalytic process that cells modulate to ensure cellular homeostasis by removing waste, replacing damaged and old organelles, and sustaining cell survival during low-nutrient conditions. As such, autophagy plays an important role in maintaining the cellular homeostasis of all hematopoietic lineages. This chapter describes the normal function of the hematopoietic system and the role of autophagy for each blood cell type, focusing on cell development and differentiation. Furthermore, we describe the role that autophagy plays in the four most common forms of leukemia and how leukemic cells may hijack this process to mitigate unfavorable conditions, such as metabolic stress or exposure to chemotherapeutics." @default.
• W3203934650 created "2021-10-11" @default.
• W3203934650 creator A5057322335 @default.
• W3203934650 creator A5081432728 @default.
• W3203934650 date "2022-01-01" @default.
• W3203934650 modified "2023-09-27" @default.
• W3203934650 title "Autophagy in hematopoiesis and leukemogenesis" @default.
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