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- W3203951414 abstract "Tumor necrosis factor (TNF) inhibitors are widely used to treat rheumatoid arthritis (RA) and their potential to retard Alzheimer's disease (AD) progression has been reported. However, their long-term effects on the dementia/AD risk remain unknown.A propensity scored matched retrospective cohort study was conducted among 40,207 patients with RA within the US Veterans Affairs health-care system from 2000 to 2020.A total of 2510 patients with RA prescribed TNF inhibitors were 1:2 matched to control patients. TNF inhibitor use was associated with reduced dementia risk (hazard ratio [HR]: 0.64, 95% confidence interval [CI]: 0.52-0.80), which was consistent as the study period increased from 5 to 20 years after RA diagnosis. TNF inhibitor use also showed a long-term effect in reducing the risk of AD (HR: 0.57, 95% CI: 0.39-0.83) during the 20 years of follow-up.TNF inhibitor use is associated with lower long-term risk of dementia/AD among US veterans with RA." @default.
- W3203951414 created "2021-10-11" @default.
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- W3203951414 date "2021-09-27" @default.
- W3203951414 modified "2023-10-16" @default.
- W3203951414 title "Potential long‐term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans" @default.
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- W3203951414 doi "https://doi.org/10.1002/alz.12465" @default.
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