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• W3203959733 endingPage "359" @default.
• W3203959733 startingPage "351" @default.
• W3203959733 abstract "Mammalian male sex differentiation is triggered during embryogenesis by the activation of the Y-linked testis-determining gene <i>SRY</i>. Since insufficient or delayed expression of <i>SRY</i> results in XY gonadal sex reversal, accurate regulation of <i>SRY</i> is critical for male development in XY animals. In humans, dysregulation of <i>SRY</i> may cause disorders of sex development. Mouse <i>Sry</i> is the most intensively studied mammalian model of sex determination. <i>Sry</i> expression is controlled in a spatially and temporally stringent manner. Several transcription factors play a key role in sex determination as trans-acting factors for <i>Sry</i> expression. In addition, recent studies have shown that several epigenetic modifications of <i>Sry</i> are involved in sex determination as cis-acting factors for <i>Sry</i> expression. Herein, we review the current understanding of transcription factor- and epigenetic modifier-mediated regulation of <i>SRY</i>/<i>Sry</i> expression." @default.
• W3203959733 created "2021-10-11" @default.
• W3203959733 creator A5039547319 @default.
• W3203959733 creator A5043826437 @default.
• W3203959733 date "2021-01-01" @default.
• W3203959733 modified "2023-10-18" @default.
• W3203959733 title "Transcriptional Regulation of the Y-Linked Mammalian Testis-Determining Gene SRY" @default.
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• W3203959733 doi "https://doi.org/10.1159/000519217" @default.
• W3203959733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34583357" @default.
• W3203959733 hasPublicationYear "2021" @default.
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