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- W3203992485 startingPage "3623" @default.
- W3203992485 abstract "Ascorbate has many biological activities that involve fundamental cellular functions such as gene expression, differentiation, and redox homeostasis. Biochemically, it serves as a cofactor for a large family of dioxygenases (> 60 members) which control transcription, formation of extracellular matrix, and epigenetic processes of histone and DNA demethylation. Ascorbate is also a major antioxidant acting as a very effective scavenger of primary reactive oxygen species. Reduction of Fe(III) by ascorbate is important for cellular uptake of iron via DMT1. Cell culture models are extensively used in toxicology and pharmacology for mechanistic studies of nutrients, drugs and other xenobiotics. High-throughput screens in vitro, such as a large-scale Tox21 program in the US, offers opportunities to assess hazardous properties of a vast and growing number of industrial chemicals. However, cells in typical cultures are severely deficient in ascorbate, raising concerns about their ability to accurately recapitulate toxic and other responses in vivo. Scarcity of ascorbate and a frequently unrecognized use of media with its thiol substitute alters stress sensitivity of cells in different directions. Remediation of ascorbate deficiency in tissue culture restores the physiological state of many cellular processes and it should improve a currently limited toxicity predictability of in vitro bioassays." @default.
- W3203992485 created "2021-10-11" @default.
- W3203992485 creator A5052707482 @default.
- W3203992485 date "2021-10-01" @default.
- W3203992485 modified "2023-10-12" @default.
- W3203992485 title "Ascorbate: antioxidant and biochemical activities and their importance for in vitro models" @default.
- W3203992485 cites W1491755566 @default.
- W3203992485 cites W1503667331 @default.
- W3203992485 cites W1507967795 @default.
- W3203992485 cites W1517698775 @default.
- W3203992485 cites W1566419077 @default.
- W3203992485 cites W1585086833 @default.
- W3203992485 cites W1602815497 @default.
- W3203992485 cites W1894394866 @default.
- W3203992485 cites W1964918855 @default.
- W3203992485 cites W1967026165 @default.
- W3203992485 cites W1968466356 @default.
- W3203992485 cites W1972605901 @default.
- W3203992485 cites W1977326112 @default.
- W3203992485 cites W1981407334 @default.
- W3203992485 cites W1984113573 @default.
- W3203992485 cites W1984689645 @default.
- W3203992485 cites W1988877971 @default.
- W3203992485 cites W1991563020 @default.
- W3203992485 cites W1991698857 @default.
- W3203992485 cites W1991952977 @default.
- W3203992485 cites W1995825628 @default.
- W3203992485 cites W1997822338 @default.
- W3203992485 cites W1997934335 @default.
- W3203992485 cites W1999094833 @default.
- W3203992485 cites W1999839463 @default.
- W3203992485 cites W2001401534 @default.
- W3203992485 cites W2005868568 @default.
- W3203992485 cites W2016923091 @default.
- W3203992485 cites W2018113993 @default.
- W3203992485 cites W2018504915 @default.
- W3203992485 cites W2020423861 @default.
- W3203992485 cites W2023765801 @default.
- W3203992485 cites W2033627886 @default.
- W3203992485 cites W2037634222 @default.
- W3203992485 cites W2041570796 @default.
- W3203992485 cites W2042216712 @default.
- W3203992485 cites W2047688922 @default.
- W3203992485 cites W2054643318 @default.
- W3203992485 cites W2056533956 @default.
- W3203992485 cites W2057679261 @default.
- W3203992485 cites W2058618870 @default.
- W3203992485 cites W2061242359 @default.
- W3203992485 cites W2067320535 @default.
- W3203992485 cites W2068157186 @default.
- W3203992485 cites W2079405203 @default.
- W3203992485 cites W2086519570 @default.
- W3203992485 cites W2091102871 @default.
- W3203992485 cites W2095081648 @default.
- W3203992485 cites W2095370504 @default.
- W3203992485 cites W2095882441 @default.
- W3203992485 cites W2110817748 @default.
- W3203992485 cites W2112651502 @default.
- W3203992485 cites W2119624946 @default.
- W3203992485 cites W2141854909 @default.
- W3203992485 cites W2144542772 @default.
- W3203992485 cites W2146537887 @default.
- W3203992485 cites W2150501188 @default.
- W3203992485 cites W2155728687 @default.
- W3203992485 cites W2157653515 @default.
- W3203992485 cites W2159177346 @default.
- W3203992485 cites W2159831588 @default.
- W3203992485 cites W2229843619 @default.
- W3203992485 cites W2253823912 @default.
- W3203992485 cites W2290836807 @default.
- W3203992485 cites W2336651556 @default.
- W3203992485 cites W2418625879 @default.
- W3203992485 cites W2470067239 @default.
- W3203992485 cites W2483061037 @default.
- W3203992485 cites W2518890317 @default.
- W3203992485 cites W2521282167 @default.
- W3203992485 cites W2523411829 @default.
- W3203992485 cites W2552872119 @default.
- W3203992485 cites W2595158292 @default.
- W3203992485 cites W2604353006 @default.
- W3203992485 cites W2617540636 @default.
- W3203992485 cites W2620959040 @default.
- W3203992485 cites W2735414420 @default.
- W3203992485 cites W2739174192 @default.
- W3203992485 cites W2746373891 @default.
- W3203992485 cites W2746871805 @default.
- W3203992485 cites W2791686911 @default.
- W3203992485 cites W2889257276 @default.
- W3203992485 cites W2892670997 @default.
- W3203992485 cites W2900824868 @default.
- W3203992485 cites W2914931008 @default.
- W3203992485 cites W2923610295 @default.
- W3203992485 cites W2942950983 @default.
- W3203992485 cites W2965712384 @default.
- W3203992485 cites W2971783845 @default.
- W3203992485 cites W3091610793 @default.
- W3203992485 cites W3093675860 @default.
- W3203992485 doi "https://doi.org/10.1007/s00204-021-03167-0" @default.