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- W3204012609 abstract "Interferon plays a crucial role in the pathogenesis and progression of tumors. Clear cell renal cell carcinoma (ccRCC) represents a prevalent malignant urinary system tumor. An effective predictive model is required to evaluate the prognosis of patients to optimize treatment.RNA-sequencing data and clinicopathological data from TCGA were involved in this retrospective study. The IFN-γ response genes with significantly different gene expression were screened out. Univariate Cox regression, LASSO regression and multivariate Cox regression were used to establish a new prognostic scoring model for the training group. Survival curves and ROC curves were drawn, and nomogram was constructed. At the same time, we conducted subgroup analysis and experimental verification using our own samples. Finally, we evaluated the relatedness between the prognostic signature and immune infiltration landscapes. In addition, the sensitivity of different risk groups to six drugs and immune checkpoint inhibitors was calculated.The IFN-γ response-related signature included 7 genes: C1S, IFI44, ST3GAL5, NUP93, TDRD7, DDX60, and ST8SIA4. The survival curves of the training and testing groups showed the model's effectiveness (P = 4.372e-11 and P = 1.08e-08, respectively), the ROC curves showed that the signature was stable, and subgroup analyses showed the wide applicability of the model (P<0.001). Multivariate Cox regression analysis showed that the risk model was an independent prognostic factor of ccRCC. A high-risk score may represent an immunosuppressive microenvironment, while the high-risk group exhibited poor sensitivity to drugs.Our findings strongly indicate that the IFN-γ response-related signature can be used as an effective prognostic indicator of ccRCC." @default.
- W3204012609 created "2021-10-11" @default.
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- W3204012609 date "2021-09-01" @default.
- W3204012609 modified "2023-10-16" @default.
- W3204012609 title "Development of an Interferon Gamma Response-Related Signature for Prediction of Survival in Clear Cell Renal Cell Carcinoma" @default.
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- W3204012609 cites W1556541386 @default.
- W3204012609 cites W163262433 @default.
- W3204012609 cites W1975519085 @default.
- W3204012609 cites W1985804036 @default.
- W3204012609 cites W1999966467 @default.
- W3204012609 cites W2000725338 @default.
- W3204012609 cites W2009314663 @default.
- W3204012609 cites W2011627030 @default.
- W3204012609 cites W2013874327 @default.
- W3204012609 cites W2025687851 @default.
- W3204012609 cites W2028691804 @default.
- W3204012609 cites W2030612376 @default.
- W3204012609 cites W2040695321 @default.
- W3204012609 cites W2046972425 @default.
- W3204012609 cites W2047871200 @default.
- W3204012609 cites W2048455086 @default.
- W3204012609 cites W2049540588 @default.
- W3204012609 cites W2050161362 @default.
- W3204012609 cites W2061122212 @default.
- W3204012609 cites W2064006166 @default.
- W3204012609 cites W2070651266 @default.
- W3204012609 cites W2075294566 @default.
- W3204012609 cites W2100495456 @default.
- W3204012609 cites W2103689170 @default.
- W3204012609 cites W2105533119 @default.
- W3204012609 cites W2110576461 @default.
- W3204012609 cites W2117692326 @default.
- W3204012609 cites W2119847512 @default.
- W3204012609 cites W2127107746 @default.
- W3204012609 cites W2131524959 @default.
- W3204012609 cites W2135400147 @default.
- W3204012609 cites W2140111836 @default.
- W3204012609 cites W2149456801 @default.
- W3204012609 cites W2157262448 @default.
- W3204012609 cites W2160040629 @default.
- W3204012609 cites W2162119603 @default.
- W3204012609 cites W2162424705 @default.
- W3204012609 cites W2181830444 @default.
- W3204012609 cites W2284518822 @default.
- W3204012609 cites W2496085280 @default.
- W3204012609 cites W2512493222 @default.
- W3204012609 cites W2520601585 @default.
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- W3204012609 cites W2591818030 @default.
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- W3204012609 cites W2805371362 @default.
- W3204012609 cites W2809152174 @default.
- W3204012609 cites W2884284961 @default.
- W3204012609 cites W2886762160 @default.
- W3204012609 cites W2894573839 @default.
- W3204012609 cites W2911812451 @default.
- W3204012609 cites W2913745075 @default.
- W3204012609 cites W2945220204 @default.
- W3204012609 cites W2949273159 @default.
- W3204012609 cites W2971180845 @default.
- W3204012609 cites W2972294778 @default.
- W3204012609 cites W2989819416 @default.
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- W3204012609 doi "https://doi.org/10.2147/jir.s334041" @default.
- W3204012609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8485924" @default.
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- W3204012609 hasPublicationYear "2021" @default.
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