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- W3204012661 abstract "The incidence of type 2 diabetes (T2D) has been increasing worldwide, and diabetic kidney disease (DKD) remains one of the leading long-term complications of T2D. Several lines of evidence indicate that glucose-lowering agents prevent the onset and progression of DKD in its early stages but are of limited efficacy in later stages of DKD. However, sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor (GLP-1R) agonists were shown to exert nephroprotective effects in patients with established DKD, i.e., those who had a reduced glomerular filtration rate. These effects cannot be solely attributed to the improved metabolic control of diabetes. In our review, we attempted to discuss the interactions of both groups of agents with inflammation and oxidative stress—the key pathways contributing to organ damage in the course of diabetes. SGLT2i and GLP-1R agonists attenuate inflammation and oxidative stress in experimental in vitro and in vivo models of DKD in several ways. In addition, we have described experiments showing the same protective mechanisms as found in DKD in non-diabetic kidney injury models as well as in some tissues and organs other than the kidney. The interaction between both drug groups, inflammation and oxidative stress appears to have a universal mechanism of organ protection in diabetes and other diseases." @default.
- W3204012661 created "2021-10-11" @default.
- W3204012661 creator A5020679087 @default.
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- W3204012661 creator A5057777286 @default.
- W3204012661 creator A5072289808 @default.
- W3204012661 date "2021-10-06" @default.
- W3204012661 modified "2023-10-14" @default.
- W3204012661 title "Inflammation and Oxidative Stress in Diabetic Kidney Disease: The Targets for SGLT2 Inhibitors and GLP-1 Receptor Agonists" @default.
- W3204012661 cites W1965929613 @default.
- W3204012661 cites W1983883248 @default.
- W3204012661 cites W1988049600 @default.
- W3204012661 cites W2034031097 @default.
- W3204012661 cites W2036909990 @default.
- W3204012661 cites W2055611619 @default.
- W3204012661 cites W2058746956 @default.
- W3204012661 cites W2064909979 @default.
- W3204012661 cites W2067314875 @default.
- W3204012661 cites W2090360729 @default.
- W3204012661 cites W2112948259 @default.
- W3204012661 cites W2115197476 @default.
- W3204012661 cites W2142097676 @default.
- W3204012661 cites W2146264128 @default.
- W3204012661 cites W2148254941 @default.
- W3204012661 cites W2167984392 @default.
- W3204012661 cites W2170781124 @default.
- W3204012661 cites W2223535266 @default.
- W3204012661 cites W2278223575 @default.
- W3204012661 cites W2288966387 @default.
- W3204012661 cites W2336813109 @default.
- W3204012661 cites W2338607841 @default.
- W3204012661 cites W2399679745 @default.
- W3204012661 cites W2405985041 @default.
- W3204012661 cites W2414527615 @default.
- W3204012661 cites W2425644022 @default.
- W3204012661 cites W2431987552 @default.
- W3204012661 cites W2470157805 @default.
- W3204012661 cites W2503476437 @default.
- W3204012661 cites W2518283902 @default.
- W3204012661 cites W2573598925 @default.
- W3204012661 cites W2582102037 @default.
- W3204012661 cites W2592545469 @default.
- W3204012661 cites W2595016203 @default.
- W3204012661 cites W2601655543 @default.
- W3204012661 cites W2749838496 @default.
- W3204012661 cites W2765580759 @default.
- W3204012661 cites W2765857094 @default.
- W3204012661 cites W2791421487 @default.
- W3204012661 cites W2793672452 @default.
- W3204012661 cites W2793903902 @default.
- W3204012661 cites W2803012276 @default.
- W3204012661 cites W2887432359 @default.
- W3204012661 cites W2897189374 @default.
- W3204012661 cites W2906935532 @default.
- W3204012661 cites W2908974911 @default.
- W3204012661 cites W2914425008 @default.
- W3204012661 cites W2916669374 @default.
- W3204012661 cites W2929823585 @default.
- W3204012661 cites W2947380079 @default.
- W3204012661 cites W2950515961 @default.
- W3204012661 cites W2953132927 @default.
- W3204012661 cites W2953693496 @default.
- W3204012661 cites W2958949191 @default.
- W3204012661 cites W2964795371 @default.
- W3204012661 cites W2973190031 @default.
- W3204012661 cites W2974260792 @default.
- W3204012661 cites W2977107131 @default.
- W3204012661 cites W2981565698 @default.
- W3204012661 cites W2984382529 @default.
- W3204012661 cites W2985008563 @default.
- W3204012661 cites W2990946575 @default.
- W3204012661 cites W2995674241 @default.
- W3204012661 cites W3000184246 @default.
- W3204012661 cites W3002400028 @default.
- W3204012661 cites W3004122635 @default.
- W3204012661 cites W3008213503 @default.
- W3204012661 cites W3010286796 @default.
- W3204012661 cites W3010565296 @default.
- W3204012661 cites W3014209855 @default.
- W3204012661 cites W3015408813 @default.
- W3204012661 cites W3016840787 @default.
- W3204012661 cites W3017093384 @default.
- W3204012661 cites W3023902731 @default.
- W3204012661 cites W3024144838 @default.
- W3204012661 cites W3025349423 @default.
- W3204012661 cites W3026086888 @default.
- W3204012661 cites W3027360658 @default.
- W3204012661 cites W3027700321 @default.
- W3204012661 cites W3033553075 @default.
- W3204012661 cites W3034453691 @default.
- W3204012661 cites W3036492313 @default.
- W3204012661 cites W3037653703 @default.
- W3204012661 cites W3045771605 @default.
- W3204012661 cites W3048562226 @default.
- W3204012661 cites W3080877256 @default.
- W3204012661 cites W3081830235 @default.
- W3204012661 cites W3082399975 @default.