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- W3204014448 abstract "Background: This study evaluated the efficacy of ibandronate, given in combination with cholecalciferol, on the levels of 25-hydroxyvitamin D (25[OH]D) and bone markers in postmenopausal women with osteoporosis. Methods: We conducted a randomized, double-blind, active-controlled, prospective, 16-week clinical trial in 20 hospitals. We randomly assigned a total of 201 postmenopausal women with osteoporosis into one of two groups: the IBN+ group (a once-monthly pill containing 150 mg ibandronate and 24,000 IU cholecalciferol, n=102) or the IBN group (a once-monthly pill containing 150 mg ibandronate alone, n=99). We measured the serum levels of 25(OH)D, parathyroid hormone (PTH), and various bone markers at both baseline and after 16 weeks of treatment. Results: After 16 weeks of treatment, the mean serum 25(OH)D level increased significantly from 21.04 to 25.33 ng/mL in the IBN+ group, but decreased significantly from 20.55 to 17.38 ng/mL in the IBN group. In both treatment groups, the mean serum PTH level significantly increased. The serum levels of bone-specific alkaline phosphatase (BSAP) and c-telopeptide of type 1 collagen (CTX) decreased significantly at 16 weeks. No significant differences were observed between the groups. However, in subjects with vitamin D deficiency, the IBN+ treatment significantly decreased the serum CTX level compared with the IBN treatment. Conclusions: In patients with postmenopausal osteoporosis, a once-monthly pill containing both ibandronate and cholecalciferol was useful for correcting vitamin D deficiency; moreover, this pill was also effective in decreasing the levels of resorption markers, especially in subjects with vitamin D deficiency, over a 16-week treatment period." @default.
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- W3204014448 date "2014-01-01" @default.
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- W3204014448 title "Slide Session : OS-END-39 ; Endocrinology : Efficacy of a Once-Monthly Pill Containing Both Ibandronate and Cholecalciferol on the Levels of 25-Hydroxyvitamin D and Bone Markers in Postmenopausal Women with Osteoporosis" @default.
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