FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204017037> ?p ?o ?g. }

• W3204017037 endingPage "106091" @default.
• W3204017037 startingPage "106091" @default.
• W3204017037 abstract "Insulin-like growth factor-1 (IGF-1) and bone morphogenetic protein 2 (BMP-2) both promote osteogenesis of bone marrow mesenchymal stem cells (BMSCs). IGF-1C, the C domain peptide of IGF-1, and P24, a BMP-2-derived peptide, both have similar biological activities as their parent growth factors. This study aimed to investigate the effects and mechanisms of polypeptides IGF-1C and P24 on the osteogenic differentiation of BMSCs.The optimum concentrations of IGF-IC and P24 were explored. The effects of the two polypeptides on BMSC proliferation and osteogenic differentiation were examined using a CCK-8 assay, flow cytometry, alkaline phosphatase (ALP) staining, ALP activity assay, alizarin red S staining, qPCR, and Western blotting. In addition, specific pathway inhibitors were utilized to explore whether the p38 and JNK pathways were involved in this process.The optimal concentration of both polypeptides was 50 μg/ml. IGF-1C and P24 synergistically promoted BMSC proliferation, increased ALP activity and calcified nodule formation, upregulated the mRNA and protein levels of Osx, Runx2, Ocn, Opn, and Col1a1, and improved the phosphorylation levels of p38 and JNK proteins. Inhibition of the pathways significantly reduced p38 and JNK activation and blocked Runx2 expression while inhibiting ALP activity and calcified nodule formation.These findings suggest that IGF-1C and P24 synergistically promote the osteogenesis of BMSCs through activation of the p38 and JNK signaling pathways." @default.
• W3204017037 created "2021-10-11" @default.
• W3204017037 creator A5030280492 @default.
• W3204017037 creator A5035788071 @default.
• W3204017037 creator A5048953539 @default.
• W3204017037 creator A5050959394 @default.
• W3204017037 creator A5051362885 @default.
• W3204017037 creator A5058483819 @default.
• W3204017037 creator A5063550108 @default.
• W3204017037 creator A5066909274 @default.
• W3204017037 creator A5085185712 @default.
• W3204017037 date "2021-12-01" @default.
• W3204017037 modified "2023-09-26" @default.
• W3204017037 title "Polypeptides IGF-1C and P24 synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells in vitro through the p38 and JNK signaling pathways" @default.
• W3204017037 cites W1962351050 @default.
• W3204017037 cites W1963689779 @default.
• W3204017037 cites W2002877736 @default.
• W3204017037 cites W2005781341 @default.
• W3204017037 cites W2023031848 @default.
• W3204017037 cites W2055747327 @default.
• W3204017037 cites W2107043674 @default.
• W3204017037 cites W2112263730 @default.
• W3204017037 cites W2126817748 @default.
• W3204017037 cites W2221267861 @default.
• W3204017037 cites W2261324366 @default.
• W3204017037 cites W2266102010 @default.
• W3204017037 cites W2524169823 @default.
• W3204017037 cites W2557596474 @default.
• W3204017037 cites W2561525464 @default.
• W3204017037 cites W2571334155 @default.
• W3204017037 cites W2593848038 @default.
• W3204017037 cites W2607906940 @default.
• W3204017037 cites W2774482123 @default.
• W3204017037 cites W2805068861 @default.
• W3204017037 cites W2858049548 @default.
• W3204017037 cites W2887587973 @default.
• W3204017037 cites W2949586474 @default.
• W3204017037 cites W3036450566 @default.
• W3204017037 cites W3038673656 @default.
• W3204017037 cites W3046550018 @default.
• W3204017037 cites W3085150136 @default.
• W3204017037 cites W4255221283 @default.
• W3204017037 doi "https://doi.org/10.1016/j.biocel.2021.106091" @default.
• W3204017037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34624508" @default.
• W3204017037 hasPublicationYear "2021" @default.
• W3204017037 type Work @default.
• W3204017037 sameAs 3204017037 @default.
• W3204017037 citedByCount "3" @default.
• W3204017037 countsByYear W32040170372022 @default.
• W3204017037 countsByYear W32040170372023 @default.
• W3204017037 crossrefType "journal-article" @default.
• W3204017037 hasAuthorship W3204017037A5030280492 @default.
• W3204017037 hasAuthorship W3204017037A5035788071 @default.
• W3204017037 hasAuthorship W3204017037A5048953539 @default.
• W3204017037 hasAuthorship W3204017037A5050959394 @default.
• W3204017037 hasAuthorship W3204017037A5051362885 @default.
• W3204017037 hasAuthorship W3204017037A5058483819 @default.
• W3204017037 hasAuthorship W3204017037A5063550108 @default.
• W3204017037 hasAuthorship W3204017037A5066909274 @default.
• W3204017037 hasAuthorship W3204017037A5085185712 @default.
• W3204017037 hasBestOaLocation W32040170372 @default.
• W3204017037 hasConcept C153911025 @default.
• W3204017037 hasConcept C160160445 @default.
• W3204017037 hasConcept C181199279 @default.
• W3204017037 hasConcept C185592680 @default.
• W3204017037 hasConcept C198826908 @default.
• W3204017037 hasConcept C202751555 @default.
• W3204017037 hasConcept C2776363554 @default.
• W3204017037 hasConcept C30352789 @default.
• W3204017037 hasConcept C51551487 @default.
• W3204017037 hasConcept C55493867 @default.
• W3204017037 hasConcept C57074206 @default.
• W3204017037 hasConcept C62478195 @default.
• W3204017037 hasConcept C86803240 @default.
• W3204017037 hasConcept C95444343 @default.
• W3204017037 hasConceptScore W3204017037C153911025 @default.
• W3204017037 hasConceptScore W3204017037C160160445 @default.
• W3204017037 hasConceptScore W3204017037C181199279 @default.
• W3204017037 hasConceptScore W3204017037C185592680 @default.
• W3204017037 hasConceptScore W3204017037C198826908 @default.
• W3204017037 hasConceptScore W3204017037C202751555 @default.
• W3204017037 hasConceptScore W3204017037C2776363554 @default.
• W3204017037 hasConceptScore W3204017037C30352789 @default.
• W3204017037 hasConceptScore W3204017037C51551487 @default.
• W3204017037 hasConceptScore W3204017037C55493867 @default.
• W3204017037 hasConceptScore W3204017037C57074206 @default.
• W3204017037 hasConceptScore W3204017037C62478195 @default.
• W3204017037 hasConceptScore W3204017037C86803240 @default.
• W3204017037 hasConceptScore W3204017037C95444343 @default.
• W3204017037 hasLocation W32040170371 @default.
• W3204017037 hasLocation W32040170372 @default.
• W3204017037 hasLocation W32040170373 @default.
• W3204017037 hasOpenAccess W3204017037 @default.
• W3204017037 hasPrimaryLocation W32040170371 @default.
• W3204017037 hasRelatedWork W2162168964 @default.
• W3204017037 hasRelatedWork W2306129533 @default.
• W3204017037 hasRelatedWork W2510464949 @default.
• W3204017037 hasRelatedWork W2767447715 @default.

• next