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- W3204017505 endingPage "150541" @default.
- W3204017505 startingPage "150541" @default.
- W3204017505 abstract "Even though the toxic effects of paracetamol (PCM) and ciprofloxacin (CPX) have been deeply studied in the last decades, the impact of the PCM-CPX mixture may induce in aquatic organisms is poorly known. Thus, the objective of this work was to investigate the teratogenic effects and oxidative stress that PCM, CPX, and their mixture induce in Danio rerio embryos. Moreover, we aimed to determine whether the PCM-CPX mixture induces more severe effects on the embryos than the individual drugs. For this purpose, zebrafish embryos (4 hpf) were exposed to environmentally relevant concentrations of PCM, CPX, and their mixture until 96 hpf. In addition, at 72 hpf and 96 hpf, we also evaluated the oxidative stress biomarkers (superoxide dismutase, catalase, glutathione peroxidase, lipid peroxidation, and hydroperoxides and carbonyl content) in the embryos. Our results demonstrated that PCM, CPX, and their mixture reduced the survival rate of embryos by up to 75%. In addition, both drugs, induced morphological alterations in the embryos, causing their death. The most observed malformations were: scoliosis, craniofacial malformations, hypopigmentation, growth retardation, pericardial edema. Concerning oxidative stress, our integrated biomarkers response (IBR) analysis demonstrated that PCM, CPX, and their mixture induce oxidative damage on the embryos. In conclusion, PCM, CPX, and their mixture can alter zebrafish embryonic development via an oxidative stress response." @default.
- W3204017505 created "2021-10-11" @default.
- W3204017505 creator A5003775743 @default.
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- W3204017505 creator A5070457304 @default.
- W3204017505 date "2022-02-01" @default.
- W3204017505 modified "2023-10-17" @default.
- W3204017505 title "Teratogenic effects induced by paracetamol, ciprofloxacin, and their mixture on Danio rerio embryos: Oxidative stress implications" @default.
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- W3204017505 cites W1969290781 @default.
- W3204017505 cites W1969564923 @default.
- W3204017505 cites W1985262844 @default.
- W3204017505 cites W1999051665 @default.
- W3204017505 cites W2004199037 @default.
- W3204017505 cites W2004689853 @default.
- W3204017505 cites W2008724643 @default.
- W3204017505 cites W2010222321 @default.
- W3204017505 cites W2014116072 @default.
- W3204017505 cites W2015751261 @default.
- W3204017505 cites W2020471713 @default.
- W3204017505 cites W2024223436 @default.
- W3204017505 cites W2024840579 @default.
- W3204017505 cites W2026517317 @default.
- W3204017505 cites W2026909018 @default.
- W3204017505 cites W2028489790 @default.
- W3204017505 cites W2033653243 @default.
- W3204017505 cites W2035680190 @default.
- W3204017505 cites W2036029912 @default.
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- W3204017505 cites W2050158033 @default.
- W3204017505 cites W2051315963 @default.
- W3204017505 cites W2061333433 @default.
- W3204017505 cites W2062750359 @default.
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- W3204017505 cites W2767674050 @default.
- W3204017505 cites W2794000137 @default.
- W3204017505 cites W2808753485 @default.
- W3204017505 cites W2931568285 @default.
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- W3204017505 cites W2956667510 @default.
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- W3204017505 doi "https://doi.org/10.1016/j.scitotenv.2021.150541" @default.
- W3204017505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34601175" @default.
- W3204017505 hasPublicationYear "2022" @default.
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