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- W3204025605 abstract "Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by a deficiency in gonadotropin-releasing hormone (GnRH). CHH is characterized by delayed puberty and/or infertility; this is because GnRH is the main component of the hypothalamic-pituitary-gonadal (HPG) axis, which is a key factor in pubertal development and reproductive function completion. However, since the development of sexual characteristics and reproduction begins in the prenatal period and is very complex and delicate, the clinical characteristics and involved genes are very diverse. In particular, the HPG axis is activated three times in a lifetime, and the symptoms and biochemical findings of CHH vary by period. In addition, related genes also vary according to the formation and activation process of the HPG axis. In this review, the clinical characteristics and treatment of CHH according to HPG axis activation and different developmental periods are reviewed, and the related genes are summarized according to their pathological mechanisms." @default.
- W3204025605 created "2021-10-11" @default.
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- W3204025605 date "2021-09-30" @default.
- W3204025605 modified "2023-10-06" @default.
- W3204025605 title "Congenital hypogonadotropic hypogonadism: from clinical characteristics to genetic aspects" @default.
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- W3204025605 doi "https://doi.org/10.23838/pfm.2021.00093" @default.
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