FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204039462> ?p ?o ?g. }

• W3204039462 endingPage "1284" @default.
• W3204039462 startingPage "1275" @default.
• W3204039462 abstract "Dyslipidemia and altered iron metabolism are typical features of non-alcoholic fatty liver disease (NAFLD). Proprotein convertase subtilisin/kexin type 7 (PCSK7), a transmembrane-anchored endonuclease, is associated with triglycerides level and processing of transferrin receptor 1. However, the significance of circulating PCSK7 has not been fully addressed, though prosegment PCSK7 is secreted from cells. We investigated the associations of plasma PCSK7 level with several parameters.Plasma PCSK7 concentration was measured in 282 subjects (male/female: 126/156) without medication of the Tanno-Sobetsu Study, a population-based cohort study.There was no significant sex difference in PCSK7 level. Current smoking habit, but not alcohol drinking habit, was associated with increased PCSK7 level. PCSK7 concentration was negatively correlated with age and blood urea nitrogen and was positively correlated with body mass index (BMI) and levels of γ-glutamyl transpeptidase (γGTP), triglycerides and fatty liver index (FLI), which is calculated by BMI, waist circumference and levels of γGTP and triglycerides, as a noninvasive and simple predictor of NAFLD. There were no significant correlations of PCSK7 level with levels of iron and plasma PCSK9, a secreted PCSK family member and a regulator of low-density lipoprotein cholesterol level. Multivariable regression analyses after adjustment of age, sex and current smoking habit showed that PCSK7 concentration was independently associated with BMI (β=0.130, P=0.035), triglycerides (β=0.141, P=0.027) or FLI (β=0.139, P=0.030).Plasma PCSK7 concentration is independently associated with chronic liver disease including obesity and elevated triglycerides level in a general population of individuals who had not regularly taken any medications." @default.
• W3204039462 created "2021-10-11" @default.
• W3204039462 creator A5001116847 @default.
• W3204039462 creator A5011904381 @default.
• W3204039462 creator A5017459316 @default.
• W3204039462 creator A5024367325 @default.
• W3204039462 creator A5034844432 @default.
• W3204039462 creator A5051066157 @default.
• W3204039462 creator A5055196139 @default.
• W3204039462 creator A5070400323 @default.
• W3204039462 creator A5070864329 @default.
• W3204039462 creator A5089380224 @default.
• W3204039462 date "2022-09-01" @default.
• W3204039462 modified "2023-10-17" @default.
• W3204039462 title "Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication" @default.
• W3204039462 cites W1516886921 @default.
• W3204039462 cites W1759982975 @default.
• W3204039462 cites W1984794443 @default.
• W3204039462 cites W1992128685 @default.
• W3204039462 cites W2003838989 @default.
• W3204039462 cites W2010689685 @default.
• W3204039462 cites W2016409202 @default.
• W3204039462 cites W2023466812 @default.
• W3204039462 cites W2029863970 @default.
• W3204039462 cites W2034060255 @default.
• W3204039462 cites W2038569244 @default.
• W3204039462 cites W2040993569 @default.
• W3204039462 cites W2043461445 @default.
• W3204039462 cites W2046722666 @default.
• W3204039462 cites W2055317075 @default.
• W3204039462 cites W2075145300 @default.
• W3204039462 cites W2077662173 @default.
• W3204039462 cites W2088301140 @default.
• W3204039462 cites W2093999428 @default.
• W3204039462 cites W2094222285 @default.
• W3204039462 cites W2095860596 @default.
• W3204039462 cites W2101733220 @default.
• W3204039462 cites W2103504539 @default.
• W3204039462 cites W2106272645 @default.
• W3204039462 cites W2111946630 @default.
• W3204039462 cites W2116488121 @default.
• W3204039462 cites W2117011155 @default.
• W3204039462 cites W2130834237 @default.
• W3204039462 cites W2142844314 @default.
• W3204039462 cites W2152189242 @default.
• W3204039462 cites W2160234571 @default.
• W3204039462 cites W2164118055 @default.
• W3204039462 cites W2183795001 @default.
• W3204039462 cites W2235517919 @default.
• W3204039462 cites W2262902147 @default.
• W3204039462 cites W2339380569 @default.
• W3204039462 cites W2346476871 @default.
• W3204039462 cites W2530844910 @default.
• W3204039462 cites W2565010590 @default.
• W3204039462 cites W2593650293 @default.
• W3204039462 cites W2596179513 @default.
• W3204039462 cites W2604315478 @default.
• W3204039462 cites W2607031541 @default.
• W3204039462 cites W2607841300 @default.
• W3204039462 cites W2737934310 @default.
• W3204039462 cites W2772777089 @default.
• W3204039462 cites W2790381739 @default.
• W3204039462 cites W2797206764 @default.
• W3204039462 cites W2805556615 @default.
• W3204039462 cites W2899997727 @default.
• W3204039462 cites W2930592959 @default.
• W3204039462 cites W2945620425 @default.
• W3204039462 cites W2999954794 @default.
• W3204039462 cites W3003548369 @default.
• W3204039462 cites W3013893325 @default.
• W3204039462 cites W3113781122 @default.
• W3204039462 cites W3154981663 @default.
• W3204039462 cites W3170546552 @default.
• W3204039462 cites W3179991577 @default.
• W3204039462 doi "https://doi.org/10.5551/jat.63159" @default.
• W3204039462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34565765" @default.
• W3204039462 hasPublicationYear "2022" @default.
• W3204039462 type Work @default.
• W3204039462 sameAs 3204039462 @default.
• W3204039462 citedByCount "3" @default.
• W3204039462 countsByYear W32040394622022 @default.
• W3204039462 countsByYear W32040394622023 @default.
• W3204039462 crossrefType "journal-article" @default.
• W3204039462 hasAuthorship W3204039462A5001116847 @default.
• W3204039462 hasAuthorship W3204039462A5011904381 @default.
• W3204039462 hasAuthorship W3204039462A5017459316 @default.
• W3204039462 hasAuthorship W3204039462A5024367325 @default.
• W3204039462 hasAuthorship W3204039462A5034844432 @default.
• W3204039462 hasAuthorship W3204039462A5051066157 @default.
• W3204039462 hasAuthorship W3204039462A5055196139 @default.
• W3204039462 hasAuthorship W3204039462A5070400323 @default.
• W3204039462 hasAuthorship W3204039462A5070864329 @default.
• W3204039462 hasAuthorship W3204039462A5089380224 @default.
• W3204039462 hasBestOaLocation W32040394621 @default.
• W3204039462 hasConcept C126322002 @default.
• W3204039462 hasConcept C134018914 @default.
• W3204039462 hasConcept C2778096610 @default.
• W3204039462 hasConcept C2778163477 @default.

• next