FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204041211> ?p ?o ?g. }

• W3204041211 endingPage "285" @default.
• W3204041211 startingPage "274" @default.
• W3204041211 abstract "ObjectiveRecurrence is known to predict laryngeal squamous cell cancer (LSCC) survival. Recurrence patterns in T4a LSCC are poorly characterized and represent a possible explanation for observed survival discrepancies by treatment rendered.Study DesignRetrospective database review.SettingVeterans Affairs national database.MethodsPatients with T4a LSCC between 2000 and 2017 were identified and stratified by treatment (chemoradiotherapy [CRT] vs total laryngectomy + neck dissection + adjuvant therapy [surgical]). Primary outcomes were locoregional and distant recurrence. Secondary outcomes of overall mortality, larynx cancer mortality, and noncancer mortality were evaluated in Cox and Fine-Gray models.ResultsA total of 1043 patients had comparable baseline demographics: 438 in the CRT group and 605 in the surgical group. Patients undergoing CRT had higher proportions of node positivity (64.6% vs 53.1%, P < .001). Locoregional and distant recurrence were less common in the surgical group (23.0% vs 37.2%, P < .001; 6.8% vs 13.3%, P < .001, respectively); however, distant metastatic rates did not differ within the N0 subgroup (P = .722). On multivariable regression, surgery demonstrated favorable locoregional recurrence (hazard ratio [HR], 0.49; 95% CI, 0.39-0.62; P < .001), distant recurrence (HR, 0.47; 95% CI, 0.31-0.71; P < .001), overall mortality (HR, 0.75; 95% CI, 0.64-0.87; P < .001), and larynx cancer mortality (HR, 0.69; 95% CI, 0.56-0.85; P < .001).ConclusionT4a LSCC survival discrepancies between surgical and nonsurgical treatment are influenced by varying recurrence behaviors. Surgery was associated with superior disease control and improved survival. Beyond the known benefit in locoregional control with surgery, there may be a protective effect on distant recurrence that depends on regional disease burden." @default.
• W3204041211 created "2021-10-11" @default.
• W3204041211 creator A5001579411 @default.
• W3204041211 creator A5004139362 @default.
• W3204041211 creator A5004819903 @default.
• W3204041211 creator A5015353609 @default.
• W3204041211 creator A5017600358 @default.
• W3204041211 creator A5030007492 @default.
• W3204041211 creator A5039221785 @default.
• W3204041211 creator A5043763331 @default.
• W3204041211 creator A5044071754 @default.
• W3204041211 creator A5044870790 @default.
• W3204041211 creator A5059026108 @default.
• W3204041211 creator A5059905131 @default.
• W3204041211 creator A5084644796 @default.
• W3204041211 creator A5091329688 @default.
• W3204041211 date "2021-10-05" @default.
• W3204041211 modified "2023-09-27" @default.
• W3204041211 title "Patterns of Failure After Definitive Treatment of T4a Larynx Cancer" @default.
• W3204041211 cites W1480186344 @default.
• W3204041211 cites W1965400754 @default.
• W3204041211 cites W2002361568 @default.
• W3204041211 cites W2012688926 @default.
• W3204041211 cites W2068083175 @default.
• W3204041211 cites W2100961085 @default.
• W3204041211 cites W2128439391 @default.
• W3204041211 cites W2131077758 @default.
• W3204041211 cites W2140753782 @default.
• W3204041211 cites W2159044625 @default.
• W3204041211 cites W2562414697 @default.
• W3204041211 cites W2735061302 @default.
• W3204041211 cites W2897570149 @default.
• W3204041211 cites W2900898764 @default.
• W3204041211 cites W2999417355 @default.
• W3204041211 cites W3036562742 @default.
• W3204041211 cites W3149996085 @default.
• W3204041211 doi "https://doi.org/10.1177/01945998211049211" @default.
• W3204041211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34609937" @default.
• W3204041211 hasPublicationYear "2021" @default.
• W3204041211 type Work @default.
• W3204041211 sameAs 3204041211 @default.
• W3204041211 citedByCount "1" @default.
• W3204041211 countsByYear W32040412112023 @default.
• W3204041211 crossrefType "journal-article" @default.
• W3204041211 hasAuthorship W3204041211A5001579411 @default.
• W3204041211 hasAuthorship W3204041211A5004139362 @default.
• W3204041211 hasAuthorship W3204041211A5004819903 @default.
• W3204041211 hasAuthorship W3204041211A5015353609 @default.
• W3204041211 hasAuthorship W3204041211A5017600358 @default.
• W3204041211 hasAuthorship W3204041211A5030007492 @default.
• W3204041211 hasAuthorship W3204041211A5039221785 @default.
• W3204041211 hasAuthorship W3204041211A5043763331 @default.
• W3204041211 hasAuthorship W3204041211A5044071754 @default.
• W3204041211 hasAuthorship W3204041211A5044870790 @default.
• W3204041211 hasAuthorship W3204041211A5059026108 @default.
• W3204041211 hasAuthorship W3204041211A5059905131 @default.
• W3204041211 hasAuthorship W3204041211A5084644796 @default.
• W3204041211 hasAuthorship W3204041211A5091329688 @default.
• W3204041211 hasConcept C121608353 @default.
• W3204041211 hasConcept C126322002 @default.
• W3204041211 hasConcept C141071460 @default.
• W3204041211 hasConcept C143998085 @default.
• W3204041211 hasConcept C144024400 @default.
• W3204041211 hasConcept C149923435 @default.
• W3204041211 hasConcept C187960798 @default.
• W3204041211 hasConcept C207103383 @default.
• W3204041211 hasConcept C2778424827 @default.
• W3204041211 hasConcept C2780084366 @default.
• W3204041211 hasConcept C2780474809 @default.
• W3204041211 hasConcept C2781157581 @default.
• W3204041211 hasConcept C44249647 @default.
• W3204041211 hasConcept C50382708 @default.
• W3204041211 hasConcept C71924100 @default.
• W3204041211 hasConcept C90924648 @default.
• W3204041211 hasConceptScore W3204041211C121608353 @default.
• W3204041211 hasConceptScore W3204041211C126322002 @default.
• W3204041211 hasConceptScore W3204041211C141071460 @default.
• W3204041211 hasConceptScore W3204041211C143998085 @default.
• W3204041211 hasConceptScore W3204041211C144024400 @default.
• W3204041211 hasConceptScore W3204041211C149923435 @default.
• W3204041211 hasConceptScore W3204041211C187960798 @default.
• W3204041211 hasConceptScore W3204041211C207103383 @default.
• W3204041211 hasConceptScore W3204041211C2778424827 @default.
• W3204041211 hasConceptScore W3204041211C2780084366 @default.
• W3204041211 hasConceptScore W3204041211C2780474809 @default.
• W3204041211 hasConceptScore W3204041211C2781157581 @default.
• W3204041211 hasConceptScore W3204041211C44249647 @default.
• W3204041211 hasConceptScore W3204041211C50382708 @default.
• W3204041211 hasConceptScore W3204041211C71924100 @default.
• W3204041211 hasConceptScore W3204041211C90924648 @default.
• W3204041211 hasIssue "2" @default.
• W3204041211 hasLocation W32040412111 @default.
• W3204041211 hasLocation W32040412112 @default.
• W3204041211 hasOpenAccess W3204041211 @default.
• W3204041211 hasPrimaryLocation W32040412111 @default.
• W3204041211 hasRelatedWork W2028931675 @default.
• W3204041211 hasRelatedWork W2046465560 @default.
• W3204041211 hasRelatedWork W2084898420 @default.

• next