FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204062334> ?p ?o ?g. }

• W3204062334 abstract "Severe trauma is the principal cause of death among young people worldwide. Hemorrhagic shock is the leading cause of death after severe trauma. Traumatic hemorrhagic shock (THS) is a complex phenomenon associating an absolute hypovolemia secondary to a sudden and significant extravascular blood loss, tissue injury, and, eventually, hypoxemia. These phenomena are responsible of secondary injuries such as coagulopathy, endotheliopathy, microcirculation failure, inflammation, and immune activation. Collectively, these dysfunctions lead to secondary organ failures and multi-organ failure (MOF). The development of MOF after severe trauma is one of the leading causes of morbidity and mortality, where immunological dysfunction plays a central role. Damage-associated molecular patterns induce an early and exaggerated activation of innate immunity and a suppression of adaptive immunity. Severe complications are associated with a prolonged and dysregulated immune–inflammatory state. The current challenge in the management of THS patients is preventing organ injury, which currently has no etiological treatment available. Modulating the immune response is a potential therapeutic strategy for preventing the complications of THS. Mesenchymal stromal cells (MSCs) are multipotent cells found in a large number of adult tissues and used in clinical practice as therapeutic agents for immunomodulation and tissue repair. There is growing evidence that their efficiency is mainly attributed to the secretion of a wide range of bioactive molecules and extracellular vesicles (EVs). Indeed, different experimental studies revealed that MSC-derived EVs (MSC-EVs) could modulate local and systemic deleterious immune response. Therefore, these new cell-free therapeutic products, easily stored and available immediately, represent a tremendous opportunity in the emergency context of shock. In this review, the pathophysiological environment of THS and, in particular, the crosstalk between the immune system and organ function are described. The potential therapeutic benefits of MSCs or their EVs in treating THS are discussed based on the current knowledge. Understanding the key mechanisms of immune deregulation leading to organ damage is a crucial element in order to optimize the preparation of EVs and potentiate their therapeutic effect." @default.
• W3204062334 created "2021-10-11" @default.
• W3204062334 creator A5034579991 @default.
• W3204062334 creator A5040447631 @default.
• W3204062334 creator A5044980560 @default.
• W3204062334 creator A5059114717 @default.
• W3204062334 creator A5064116117 @default.
• W3204062334 creator A5088096181 @default.
• W3204062334 date "2021-09-29" @default.
• W3204062334 modified "2023-10-16" @default.
• W3204062334 title "Therapeutic Potential of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Prevention of Organ Injuries Induced by Traumatic Hemorrhagic Shock" @default.
• W3204062334 cites W1016461115 @default.
• W3204062334 cites W1455282968 @default.
• W3204062334 cites W1482244509 @default.
• W3204062334 cites W1503343720 @default.
• W3204062334 cites W1555300211 @default.
• W3204062334 cites W1561245877 @default.
• W3204062334 cites W1596258860 @default.
• W3204062334 cites W1600560134 @default.
• W3204062334 cites W1691186793 @default.
• W3204062334 cites W1705055750 @default.
• W3204062334 cites W188592111 @default.
• W3204062334 cites W1922823402 @default.
• W3204062334 cites W1924919685 @default.
• W3204062334 cites W1936506769 @default.
• W3204062334 cites W1960997296 @default.
• W3204062334 cites W1964507181 @default.
• W3204062334 cites W1965693998 @default.
• W3204062334 cites W1967183267 @default.
• W3204062334 cites W1968805845 @default.
• W3204062334 cites W1969269805 @default.
• W3204062334 cites W1969354148 @default.
• W3204062334 cites W1973404097 @default.
• W3204062334 cites W1974693697 @default.
• W3204062334 cites W1975255476 @default.
• W3204062334 cites W1977109906 @default.
• W3204062334 cites W1979050701 @default.
• W3204062334 cites W1979726128 @default.
• W3204062334 cites W1982408656 @default.
• W3204062334 cites W1985410547 @default.
• W3204062334 cites W1987442085 @default.
• W3204062334 cites W1988772399 @default.
• W3204062334 cites W1989968713 @default.
• W3204062334 cites W1992723596 @default.
• W3204062334 cites W1993429855 @default.
• W3204062334 cites W1994008257 @default.
• W3204062334 cites W1994190235 @default.
• W3204062334 cites W1994521618 @default.
• W3204062334 cites W1995084062 @default.
• W3204062334 cites W1996094005 @default.
• W3204062334 cites W1997093811 @default.
• W3204062334 cites W1998226806 @default.
• W3204062334 cites W1999755139 @default.
• W3204062334 cites W2001058555 @default.
• W3204062334 cites W2001921869 @default.
• W3204062334 cites W2002218662 @default.
• W3204062334 cites W2002375003 @default.
• W3204062334 cites W2002764610 @default.
• W3204062334 cites W2004150448 @default.
• W3204062334 cites W2004608935 @default.
• W3204062334 cites W2006006000 @default.
• W3204062334 cites W2006679777 @default.
• W3204062334 cites W2009351467 @default.
• W3204062334 cites W2009599333 @default.
• W3204062334 cites W2010381370 @default.
• W3204062334 cites W2013860796 @default.
• W3204062334 cites W2015164426 @default.
• W3204062334 cites W2015828287 @default.
• W3204062334 cites W2020440201 @default.
• W3204062334 cites W2020995800 @default.
• W3204062334 cites W2021916724 @default.
• W3204062334 cites W2023000147 @default.
• W3204062334 cites W2024870847 @default.
• W3204062334 cites W2024885761 @default.
• W3204062334 cites W2024971445 @default.
• W3204062334 cites W2025371271 @default.
• W3204062334 cites W2028491403 @default.
• W3204062334 cites W2028992611 @default.
• W3204062334 cites W2029022410 @default.
• W3204062334 cites W2030196938 @default.
• W3204062334 cites W2030614727 @default.
• W3204062334 cites W2031308244 @default.
• W3204062334 cites W2031696610 @default.
• W3204062334 cites W2032497440 @default.
• W3204062334 cites W2032622353 @default.
• W3204062334 cites W2036452348 @default.
• W3204062334 cites W2038413306 @default.
• W3204062334 cites W2038877090 @default.
• W3204062334 cites W2039255438 @default.
• W3204062334 cites W2039324671 @default.
• W3204062334 cites W2042487476 @default.
• W3204062334 cites W2047003816 @default.
• W3204062334 cites W2048354810 @default.
• W3204062334 cites W2048845788 @default.
• W3204062334 cites W2049820468 @default.
• W3204062334 cites W2054100516 @default.
• W3204062334 cites W2055004642 @default.
• W3204062334 cites W2055094488 @default.
• W3204062334 cites W2055424631 @default.
• W3204062334 cites W2056917800 @default.

• next