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- W3204067162 abstract "Long-term hypertension is known as a major risk factor for cardiovascular and chronic kidney disease (CKD). The Renin-angiotensin system (RAS) plays a key role in hypertension pathogenesis. Angiotensin II (Ang II) enhancement in Ang II-dependent hypertension leads to progressive CKD and kidney fibrosis. In the two-kidney one-clip model (2K1C), more renin is synthesized in the principal cells of the collecting duct than juxtaglomerular cells (JGCs). An increase of renal Ang I and Ang II levels and a decrease of renal cortical and medullary Ang 1–7 occur in both kidneys of the 2K1C hypertensive rat model. In addition, the activity of the angiotensin-converting enzyme (ACE) increases, while ACE2’s activity decreases in the medullary region of both kidneys in the 2K1C hypertensive model. Also, the renal prolyl carboxypeptidase (PrCP) expression and its activity reduce in the clipped kidneys. The imbalance in the production of renal ACE, ACE2, and PrCP expression causes the progression of renal injury. Intrarenal angiotensinogen (AGT) expression and urine AGT (uAGT) excretion rates in the unclipped kidney are greater than the clipped kidney in the 2K1C hypertensive rat model. The enhancement of Ang II in the clipped kidney is related to renin secretion, while the elevation of intrarenal Ang II in the unclipped kidney is related to stimulation of AGT mRNA and protein in proximal tubule cells by a direct effect of systemic Ang II level. Ang II-dependent hypertension enhances macrophages and T-cell infiltration into the kidney which increases cytokines, and AGT synthesis in proximal tubules is stimulated via cytokines. Accumulation of inflammatory cells in the kidney aggravates hypertension and renal damage. Moreover, Ang II-dependent hypertension alters renal Ang II type 1 & 2 receptors (AT1R & AT2R) and Mas receptor (MasR) expression, and the renal interstitial fluid bradykinin, nitric oxide, and cGMP response to AT1R, AT2R, or BK B2-receptor antagonists. Based on a variety of sources including PubMed, Google Scholar, Scopus, and Science-Direct, in the current review, we will discuss the role of RAS-induced secondary hypertension on the alteration of renal function." @default.
- W3204067162 created "2021-10-11" @default.
- W3204067162 creator A5047431349 @default.
- W3204067162 creator A5083109275 @default.
- W3204067162 date "2021-10-04" @default.
- W3204067162 modified "2023-09-26" @default.
- W3204067162 title "Renin-Angiotensin System Induced Secondary Hypertension: The Alteration of Kidney Function and Structure" @default.
- W3204067162 cites W1118162442 @default.
- W3204067162 cites W1584309458 @default.
- W3204067162 cites W1732283899 @default.
- W3204067162 cites W1840798497 @default.
- W3204067162 cites W1852486766 @default.
- W3204067162 cites W1970065265 @default.
- W3204067162 cites W1976926197 @default.
- W3204067162 cites W1977672980 @default.
- W3204067162 cites W1981759781 @default.
- W3204067162 cites W1984261234 @default.
- W3204067162 cites W1984799912 @default.
- W3204067162 cites W1985436679 @default.
- W3204067162 cites W1987514832 @default.
- W3204067162 cites W1989729456 @default.
- W3204067162 cites W1990423948 @default.
- W3204067162 cites W1996090279 @default.
- W3204067162 cites W2003581668 @default.
- W3204067162 cites W2018882645 @default.
- W3204067162 cites W2019526263 @default.
- W3204067162 cites W2021888498 @default.
- W3204067162 cites W2024076076 @default.
- W3204067162 cites W2027201636 @default.
- W3204067162 cites W2032694443 @default.
- W3204067162 cites W2033413538 @default.
- W3204067162 cites W2034536217 @default.
- W3204067162 cites W2038460784 @default.
- W3204067162 cites W2043052195 @default.
- W3204067162 cites W2043533097 @default.
- W3204067162 cites W2046090148 @default.
- W3204067162 cites W2050253839 @default.
- W3204067162 cites W2051185167 @default.
- W3204067162 cites W2052602765 @default.
- W3204067162 cites W2053373031 @default.
- W3204067162 cites W2054960859 @default.
- W3204067162 cites W2056038215 @default.
- W3204067162 cites W2057726446 @default.
- W3204067162 cites W2058713776 @default.
- W3204067162 cites W2059287255 @default.
- W3204067162 cites W2062627307 @default.
- W3204067162 cites W2063360581 @default.
- W3204067162 cites W2065088664 @default.
- W3204067162 cites W2068838843 @default.
- W3204067162 cites W2069286421 @default.
- W3204067162 cites W2070674399 @default.
- W3204067162 cites W2076722320 @default.
- W3204067162 cites W2077619366 @default.
- W3204067162 cites W2077755327 @default.
- W3204067162 cites W2079026534 @default.
- W3204067162 cites W2080209849 @default.
- W3204067162 cites W2085719479 @default.
- W3204067162 cites W2085778795 @default.
- W3204067162 cites W2088686140 @default.
- W3204067162 cites W2090406694 @default.
- W3204067162 cites W2092194580 @default.
- W3204067162 cites W2092532993 @default.
- W3204067162 cites W2093898569 @default.
- W3204067162 cites W2095238685 @default.
- W3204067162 cites W2096421784 @default.
- W3204067162 cites W2098827117 @default.
- W3204067162 cites W2099487508 @default.
- W3204067162 cites W2103112195 @default.
- W3204067162 cites W2104323543 @default.
- W3204067162 cites W2104966958 @default.
- W3204067162 cites W2105404134 @default.
- W3204067162 cites W2106197011 @default.
- W3204067162 cites W2107396256 @default.
- W3204067162 cites W2109018429 @default.
- W3204067162 cites W2109785137 @default.
- W3204067162 cites W2112609057 @default.
- W3204067162 cites W2114614037 @default.
- W3204067162 cites W2115816290 @default.
- W3204067162 cites W2116520916 @default.
- W3204067162 cites W2118713434 @default.
- W3204067162 cites W2125068393 @default.
- W3204067162 cites W2129050339 @default.
- W3204067162 cites W2129348353 @default.
- W3204067162 cites W2130423617 @default.
- W3204067162 cites W2132762600 @default.
- W3204067162 cites W2134319114 @default.
- W3204067162 cites W2136976145 @default.
- W3204067162 cites W2138043907 @default.
- W3204067162 cites W2138432059 @default.
- W3204067162 cites W2139147784 @default.
- W3204067162 cites W2139380328 @default.
- W3204067162 cites W2140446943 @default.
- W3204067162 cites W2141819267 @default.
- W3204067162 cites W2147052280 @default.
- W3204067162 cites W2148934065 @default.
- W3204067162 cites W2149211311 @default.
- W3204067162 cites W2149743327 @default.
- W3204067162 cites W2150441787 @default.