FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204075898> ?p ?o ?g. }

• W3204075898 endingPage "190" @default.
• W3204075898 startingPage "185" @default.
• W3204075898 abstract "The aim of this study was to evaluate nitric oxide (NO) levels and lipid peroxidation (Malondialdehyde: MDA) in plasma of dogs naturally infected by Ehrlichia canis , and to determine the effect of doxycycline on clinical, hematological, and oxidative parameters. Clinical and hematological parameters and positive serology for E. canis were used to diagnose the disease. Plasma samples were obtained from infected animals ( n = 15) before and after doxycycline treatment (10 mg/kg, daily for 28 days) and from healthy dogs ( n = 8). The concentrations of NO and MDA were determined by Griess’ assay and thiobarbituric acid assay, respectively. Increased plasmatic levels of NO and MDA were observed in infected dogs compared to healthy animals ( P < 0.001), those levels decreased after doxycycline treatment ( P < 0.001). Altered hematological parameters (hemoglobin, hematocrit, leukocyte, and platelet counts) in infected dogs, returned to normal values after antibiotic treatment ( P < 0.001). High and positive correlation was obtained between NO levels and MDA content ( r = 0.7812; P < 0.001). This study shows that dogs infected by E. canis develop oxidative stress that might be involved in the pathophysiology of the disease and highlights the beneficial effect of doxycycline in this infection. Le but de cette étude était d’évaluer les niveaux d’oxyde nitrique (NO) et la peroxydation lipidique (Malondialdehyde : MDA) dans le plasma de chiens naturellement infectés par Ehrlichia canis , et de déterminer l’effet de la doxycycline sur les paramètres cliniques, hématologiques et oxydatifs. Les paramètres cliniques et hématologiques et un examen sérologique positif pour E. canis ont été utilisés pour diagnostiquer la maladie. Des échantillons de plasma ont été obtenus à partir d’animaux infectés ( n = 15) avant et après le traitement à la doxycycline (10 mg/kg, par jour pendant 28 jours) et de chiens sains ( n = 8). Les concentrations de NO et de MDA ont été déterminées respectivement par le test de Griess et le test de l’acide thiobarbiturique. Une augmentation des niveaux plasmatiques de NO et de MDA a été observée chez les chiens infectés par rapport aux animaux sains ( p < 0,001), ces niveaux ont diminué après le traitement à la doxycycline ( p < 0,001). Les paramètres hématologiques altérés (hémoglobine, hématocrite, numération leucocytaire et plaquettaire) chez les chiens infectés, sont revenus à des valeurs normales après le traitement antibiotique ( p < 0,001). Une corrélation élevée et positive a été obtenue entre les niveaux de NO et la teneur en MDA ( r = 0,7812 ; p < 0,001). Cette étude montre que les chiens infectés par E. canis développent un stress oxydatif qui pourrait être impliqué dans la physiopathologie de la maladie et souligne l’effet bénéfique de la doxycycline dans cette infection." @default.
• W3204075898 created "2021-10-11" @default.
• W3204075898 creator A5025803082 @default.
• W3204075898 creator A5050614608 @default.
• W3204075898 creator A5064505703 @default.
• W3204075898 date "2021-12-01" @default.
• W3204075898 modified "2023-09-27" @default.
• W3204075898 title "Increased plasma levels of nitric oxide and malondialdehyde in dogs infected by Ehrlichia canis: Effect of doxycycline treatment" @default.
• W3204075898 cites W1489614864 @default.
• W3204075898 cites W1528557278 @default.
• W3204075898 cites W1983310681 @default.
• W3204075898 cites W1990802251 @default.
• W3204075898 cites W2005052043 @default.
• W3204075898 cites W2025639892 @default.
• W3204075898 cites W2053453212 @default.
• W3204075898 cites W2054698391 @default.
• W3204075898 cites W2059182177 @default.
• W3204075898 cites W2084992389 @default.
• W3204075898 cites W2122693804 @default.
• W3204075898 cites W2127718209 @default.
• W3204075898 cites W2131184698 @default.
• W3204075898 cites W2131841613 @default.
• W3204075898 cites W2140192492 @default.
• W3204075898 cites W2144979057 @default.
• W3204075898 cites W2151157722 @default.
• W3204075898 cites W2152520776 @default.
• W3204075898 cites W2173982160 @default.
• W3204075898 cites W2219403692 @default.
• W3204075898 cites W2484003804 @default.
• W3204075898 cites W2510590968 @default.
• W3204075898 cites W2948915498 @default.
• W3204075898 cites W4229993736 @default.
• W3204075898 doi "https://doi.org/10.1016/j.anicom.2021.09.002" @default.
• W3204075898 hasPublicationYear "2021" @default.
• W3204075898 type Work @default.
• W3204075898 sameAs 3204075898 @default.
• W3204075898 citedByCount "1" @default.
• W3204075898 countsByYear W32040758982022 @default.
• W3204075898 crossrefType "journal-article" @default.
• W3204075898 hasAuthorship W3204075898A5025803082 @default.
• W3204075898 hasAuthorship W3204075898A5050614608 @default.
• W3204075898 hasAuthorship W3204075898A5064505703 @default.
• W3204075898 hasConcept C126322002 @default.
• W3204075898 hasConcept C159654299 @default.
• W3204075898 hasConcept C18903297 @default.
• W3204075898 hasConcept C203014093 @default.
• W3204075898 hasConcept C2776151105 @default.
• W3204075898 hasConcept C2777179404 @default.
• W3204075898 hasConcept C2778401633 @default.
• W3204075898 hasConcept C2779557943 @default.
• W3204075898 hasConcept C2779620486 @default.
• W3204075898 hasConcept C2779657035 @default.
• W3204075898 hasConcept C2781246620 @default.
• W3204075898 hasConcept C42972112 @default.
• W3204075898 hasConcept C45189115 @default.
• W3204075898 hasConcept C501593827 @default.
• W3204075898 hasConcept C519581460 @default.
• W3204075898 hasConcept C71924100 @default.
• W3204075898 hasConcept C86803240 @default.
• W3204075898 hasConcept C89423630 @default.
• W3204075898 hasConceptScore W3204075898C126322002 @default.
• W3204075898 hasConceptScore W3204075898C159654299 @default.
• W3204075898 hasConceptScore W3204075898C18903297 @default.
• W3204075898 hasConceptScore W3204075898C203014093 @default.
• W3204075898 hasConceptScore W3204075898C2776151105 @default.
• W3204075898 hasConceptScore W3204075898C2777179404 @default.
• W3204075898 hasConceptScore W3204075898C2778401633 @default.
• W3204075898 hasConceptScore W3204075898C2779557943 @default.
• W3204075898 hasConceptScore W3204075898C2779620486 @default.
• W3204075898 hasConceptScore W3204075898C2779657035 @default.
• W3204075898 hasConceptScore W3204075898C2781246620 @default.
• W3204075898 hasConceptScore W3204075898C42972112 @default.
• W3204075898 hasConceptScore W3204075898C45189115 @default.
• W3204075898 hasConceptScore W3204075898C501593827 @default.
• W3204075898 hasConceptScore W3204075898C519581460 @default.
• W3204075898 hasConceptScore W3204075898C71924100 @default.
• W3204075898 hasConceptScore W3204075898C86803240 @default.
• W3204075898 hasConceptScore W3204075898C89423630 @default.
• W3204075898 hasIssue "4" @default.
• W3204075898 hasLocation W32040758981 @default.
• W3204075898 hasOpenAccess W3204075898 @default.
• W3204075898 hasPrimaryLocation W32040758981 @default.
• W3204075898 hasRelatedWork W1558800866 @default.
• W3204075898 hasRelatedWork W1713177076 @default.
• W3204075898 hasRelatedWork W2053453212 @default.
• W3204075898 hasRelatedWork W2098515394 @default.
• W3204075898 hasRelatedWork W2144979057 @default.
• W3204075898 hasRelatedWork W2154760975 @default.
• W3204075898 hasRelatedWork W2188273241 @default.
• W3204075898 hasRelatedWork W2410584427 @default.
• W3204075898 hasRelatedWork W2417013705 @default.
• W3204075898 hasRelatedWork W980440478 @default.
• W3204075898 hasVolume "56" @default.
• W3204075898 isParatext "false" @default.
• W3204075898 isRetracted "false" @default.
• W3204075898 magId "3204075898" @default.
• W3204075898 workType "article" @default.