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- W3204076181 endingPage "105278" @default.
- W3204076181 startingPage "105278" @default.
- W3204076181 abstract "The optimal timing of orthodontic tooth movement (OTM) could allow earlier tooth movements across alveolar bone defects while minimizing the adverse effects. The objective of this scoping systematic review was therefore designed to review pre-clinical animal studies on the ideal protocol for the timing of orthodontic traction across alveolar defects augmented with synthetic scaffolds.Following the PRISMA-ScR guidelines, three electronic databases were searched (Pubmed, Scopus and Web of Science).A total of twelve studies were included in the final review that reported on small-animal (rats, guinea pigs, rabbits) and large-animal (dogs and goats) models. Based on the grafting biomaterials, eight papers used cell-free scaffolds, four articles utilised cell-based scaffolds. The timing protocol for the initiation of OTM employed in the studies ranged from immediate to 6 months after surgical grafting. Only four studies included autologous bone graft (gold standard) as positive control. Most papers reported positive results with regards to the rate of OTM and bone augmentation effects while only a few reported side effects such as root resorptions. Overall, the included articles showed a massive heterogeneity in terms of the animal bone defect model characteristics, scaffold materials, study designs, parameters of OTM and methods of analysis.Since there was inadequate evidence to identify the optimal protocol of OTM, optimization of animal bone defect models and outcome measurements is needed to improve the translational ability of future studies." @default.
- W3204076181 created "2021-10-11" @default.
- W3204076181 creator A5021246185 @default.
- W3204076181 creator A5055534172 @default.
- W3204076181 creator A5079253628 @default.
- W3204076181 date "2021-12-01" @default.
- W3204076181 modified "2023-09-29" @default.
- W3204076181 title "Timing of orthodontic tooth movement in bone defects repaired with synthetic scaffolds: A scoping review of animal studies" @default.
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- W3204076181 doi "https://doi.org/10.1016/j.archoralbio.2021.105278" @default.
- W3204076181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34634537" @default.
- W3204076181 hasPublicationYear "2021" @default.