FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204091005> ?p ?o ?g. }

• W3204091005 abstract "Abstract Older adults tend to display greater brain activation in the non-dominant hemisphere during even basic sensorimotor responses. It is debated whether this Hemispheric Asymmetry Reduction in Older Adults (HAROLD) reflects a compensatory mechanism. Across two independent fMRI experiments involving an adult-lifespan human sample (N = 586 and N = 81; approximately half female) who performed right hand finger responses, we distinguished between these hypotheses using behavioural and multivariate Bayes (MVB) decoding approaches. Standard univariate analyses replicated a HAROLD pattern in motor cortex, but in- and out-of-scanner behavioural results both demonstrated evidence against a compensatory relationship, in that reaction time measures of task performance in older adults did not relate to ipsilateral motor activity. Likewise, MVB showed that this increased ipsilateral activity in older adults did not carry additional information, and if anything, combining ipsilateral with contralateral activity patterns reduced action decoding in older adults (at least in Experiment 1). These results contradict the hypothesis that HAROLD is compensatory, and instead suggest that the age-related, ipsilateral hyper-activation is non-specific, in line with alternative hypotheses about age-related reductions in neural efficiency/differentiation or inter-hemispheric inhibition. Significance Statement A key goal in the cognitive neuroscience of ageing is to provide a mechanistic explanation of how brain-behaviour relationships change with age. One interpretation of the common finding that task-based hemispheric activity becomes more symmetrical in older adults, is that this shift reflects a compensatory mechanism, with the non-dominant hemisphere needing to “help out” with computations normally performed by the dominant hemisphere. Contrary to this view, our behavioural and brain data indicate that the additional activity in ipsilateral motor cortex in older adults is not reflective of better task performance nor better neural representations of finger actions." @default.
• W3204091005 created "2021-10-11" @default.
• W3204091005 creator A5002502518 @default.
• W3204091005 creator A5025647319 @default.
• W3204091005 creator A5034626652 @default.
• W3204091005 creator A5036222195 @default.
• W3204091005 date "2021-06-02" @default.
• W3204091005 modified "2023-09-24" @default.
• W3204091005 title "Does Hemispheric Asymmetry Reduction in Older Adults (HAROLD) in motor cortex reflect compensation?" @default.
• W3204091005 cites W124680550 @default.
• W3204091005 cites W1481228261 @default.
• W3204091005 cites W1533685749 @default.
• W3204091005 cites W1779672325 @default.
• W3204091005 cites W1824528708 @default.
• W3204091005 cites W1967792191 @default.
• W3204091005 cites W1967966396 @default.
• W3204091005 cites W1968135525 @default.
• W3204091005 cites W1969336180 @default.
• W3204091005 cites W1973057905 @default.
• W3204091005 cites W1978662219 @default.
• W3204091005 cites W1984866242 @default.
• W3204091005 cites W1987733777 @default.
• W3204091005 cites W1988252404 @default.
• W3204091005 cites W1989725192 @default.
• W3204091005 cites W1990817194 @default.
• W3204091005 cites W1991660386 @default.
• W3204091005 cites W1994510169 @default.
• W3204091005 cites W1998855584 @default.
• W3204091005 cites W2001555513 @default.
• W3204091005 cites W2010217187 @default.
• W3204091005 cites W2017146523 @default.
• W3204091005 cites W2017558624 @default.
• W3204091005 cites W2019604700 @default.
• W3204091005 cites W2020811750 @default.
• W3204091005 cites W2046104092 @default.
• W3204091005 cites W2049524944 @default.
• W3204091005 cites W2051835854 @default.
• W3204091005 cites W2053913308 @default.
• W3204091005 cites W2054275233 @default.
• W3204091005 cites W2057078819 @default.
• W3204091005 cites W2057366948 @default.
• W3204091005 cites W2058189433 @default.
• W3204091005 cites W2059976173 @default.
• W3204091005 cites W2061195971 @default.
• W3204091005 cites W2061997902 @default.
• W3204091005 cites W2066439376 @default.
• W3204091005 cites W2089725106 @default.
• W3204091005 cites W2093556213 @default.
• W3204091005 cites W2097015231 @default.
• W3204091005 cites W2099389810 @default.
• W3204091005 cites W2108884077 @default.
• W3204091005 cites W2112588301 @default.
• W3204091005 cites W2113257799 @default.
• W3204091005 cites W2115918931 @default.
• W3204091005 cites W2117971276 @default.
• W3204091005 cites W2121747917 @default.
• W3204091005 cites W2127424725 @default.
• W3204091005 cites W2128884192 @default.
• W3204091005 cites W2132361590 @default.
• W3204091005 cites W2135891908 @default.
• W3204091005 cites W2143841415 @default.
• W3204091005 cites W2144828882 @default.
• W3204091005 cites W2155298532 @default.
• W3204091005 cites W2160430288 @default.
• W3204091005 cites W2161220328 @default.
• W3204091005 cites W2167663674 @default.
• W3204091005 cites W2170362188 @default.
• W3204091005 cites W2497624754 @default.
• W3204091005 cites W2617838712 @default.
• W3204091005 cites W2885157817 @default.
• W3204091005 cites W2896204498 @default.
• W3204091005 cites W2951337022 @default.
• W3204091005 cites W3004625228 @default.
• W3204091005 cites W3012940478 @default.
• W3204091005 cites W3039570785 @default.
• W3204091005 cites W4231324690 @default.
• W3204091005 cites W4243115481 @default.
• W3204091005 cites W4250423192 @default.
• W3204091005 doi "https://doi.org/10.1101/2021.06.02.446015" @default.
• W3204091005 hasPublicationYear "2021" @default.
• W3204091005 type Work @default.
• W3204091005 sameAs 3204091005 @default.
• W3204091005 citedByCount "2" @default.
• W3204091005 countsByYear W32040910052021 @default.
• W3204091005 crossrefType "posted-content" @default.
• W3204091005 hasAuthorship W3204091005A5002502518 @default.
• W3204091005 hasAuthorship W3204091005A5025647319 @default.
• W3204091005 hasAuthorship W3204091005A5034626652 @default.
• W3204091005 hasAuthorship W3204091005A5036222195 @default.
• W3204091005 hasBestOaLocation W32040910051 @default.
• W3204091005 hasConcept C105702510 @default.
• W3204091005 hasConcept C126322002 @default.
• W3204091005 hasConcept C138496976 @default.
• W3204091005 hasConcept C140530291 @default.
• W3204091005 hasConcept C15744967 @default.
• W3204091005 hasConcept C169760540 @default.
• W3204091005 hasConcept C169900460 @default.
• W3204091005 hasConcept C180747234 @default.
• W3204091005 hasConcept C24998067 @default.
• W3204091005 hasConcept C2777348757 @default.

• next