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- W3204092655 abstract "Cells dynamically adapt organelle size to current physiological demand. Organelle growth requires membrane biogenesis and therefore needs to be coordinated with lipid metabolism. The endoplasmic reticulum (ER) can undergo massive expansion, but the underlying regulatory mechanisms are largely unclear. Here, we describe a genetic screen for factors involved in ER membrane expansion in budding yeast and identify the ER transmembrane protein Ice2 as a strong hit. We show that Ice2 promotes ER membrane biogenesis by opposing the phosphatidic acid phosphatase Pah1, called lipin in metazoa. Specifically, Ice2 inhibits the conserved Nem1-Spo7 complex and thus suppresses the dephosphorylation and activation of Pah1. Furthermore, Ice2 cooperates with the transcriptional regulation of lipid synthesis genes and helps to maintain cell homeostasis during ER stress. These findings establish the control of the lipin phosphatase complex as an important mechanism for regulating ER membrane biogenesis." @default.
- W3204092655 created "2021-10-11" @default.
- W3204092655 creator A5009471028 @default.
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- W3204092655 creator A5063617637 @default.
- W3204092655 date "2021-10-06" @default.
- W3204092655 modified "2023-10-14" @default.
- W3204092655 title "Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex" @default.
- W3204092655 cites W1772671448 @default.
- W3204092655 cites W1963796773 @default.
- W3204092655 cites W1966072209 @default.
- W3204092655 cites W1973798216 @default.
- W3204092655 cites W1975039456 @default.
- W3204092655 cites W1975849160 @default.
- W3204092655 cites W1977222014 @default.
- W3204092655 cites W1977603207 @default.
- W3204092655 cites W1980730766 @default.
- W3204092655 cites W1981323962 @default.
- W3204092655 cites W1984954439 @default.
- W3204092655 cites W1988988264 @default.
- W3204092655 cites W1990338406 @default.
- W3204092655 cites W1993697882 @default.
- W3204092655 cites W2000371661 @default.
- W3204092655 cites W2004341529 @default.
- W3204092655 cites W2009741382 @default.
- W3204092655 cites W2011632041 @default.
- W3204092655 cites W2011764708 @default.
- W3204092655 cites W2020725477 @default.
- W3204092655 cites W2022889543 @default.
- W3204092655 cites W2028878583 @default.
- W3204092655 cites W2031404843 @default.
- W3204092655 cites W2040993603 @default.
- W3204092655 cites W2041444673 @default.
- W3204092655 cites W2042688172 @default.
- W3204092655 cites W2052660293 @default.
- W3204092655 cites W2059643803 @default.
- W3204092655 cites W2070425044 @default.
- W3204092655 cites W2087250756 @default.
- W3204092655 cites W2091936353 @default.
- W3204092655 cites W2094758309 @default.
- W3204092655 cites W2098293220 @default.
- W3204092655 cites W2099712422 @default.
- W3204092655 cites W2102651270 @default.
- W3204092655 cites W2106114441 @default.
- W3204092655 cites W2113036580 @default.
- W3204092655 cites W2116613524 @default.
- W3204092655 cites W2129537329 @default.
- W3204092655 cites W2131210945 @default.
- W3204092655 cites W2133048033 @default.
- W3204092655 cites W2133102806 @default.
- W3204092655 cites W2133992568 @default.
- W3204092655 cites W2134962337 @default.
- W3204092655 cites W2136331587 @default.
- W3204092655 cites W2136338518 @default.
- W3204092655 cites W2141122227 @default.
- W3204092655 cites W2142437744 @default.
- W3204092655 cites W2143063963 @default.
- W3204092655 cites W2146625037 @default.
- W3204092655 cites W2154046032 @default.
- W3204092655 cites W2154061435 @default.
- W3204092655 cites W2160238206 @default.
- W3204092655 cites W2165615730 @default.
- W3204092655 cites W2168135619 @default.
- W3204092655 cites W2338194256 @default.
- W3204092655 cites W2412650844 @default.
- W3204092655 cites W2501015950 @default.
- W3204092655 cites W2541068854 @default.
- W3204092655 cites W2551836638 @default.
- W3204092655 cites W2555419730 @default.
- W3204092655 cites W2606913462 @default.
- W3204092655 cites W2745109795 @default.
- W3204092655 cites W2766477555 @default.
- W3204092655 cites W2785428883 @default.
- W3204092655 cites W2793588097 @default.
- W3204092655 cites W2803357558 @default.
- W3204092655 cites W2808865973 @default.
- W3204092655 cites W2888618670 @default.
- W3204092655 cites W2891616464 @default.
- W3204092655 cites W2901837422 @default.
- W3204092655 cites W2902875229 @default.
- W3204092655 cites W2903326024 @default.
- W3204092655 cites W2904499052 @default.
- W3204092655 cites W2922050669 @default.
- W3204092655 cites W2924119339 @default.
- W3204092655 cites W2989709170 @default.
- W3204092655 cites W2992148597 @default.
- W3204092655 cites W3019317568 @default.
- W3204092655 cites W3034249483 @default.
- W3204092655 cites W3134163889 @default.
- W3204092655 cites W3160429660 @default.
- W3204092655 cites W3184216069 @default.
- W3204092655 cites W4221100616 @default.
- W3204092655 doi "https://doi.org/10.15252/embj.2021107958" @default.
- W3204092655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8591542" @default.
- W3204092655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34617598" @default.
- W3204092655 hasPublicationYear "2021" @default.