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• W3204097783 endingPage "101239" @default.
• W3204097783 startingPage "101239" @default.
• W3204097783 abstract "Prosthetic joint infection (PJI) is the most common reason for early revision of total joint replacements. In these applications, antibiotic-loaded bone cement (ALBC) is widely used both as a prophylaxis and treatment/management for PJI. However, over time, the bacterial strains most frequently associated with PJI have become resistant to the antibiotics commonly used in ALBC's such as gentamicin and vancomycin. The present study was an in vitro evaluation of telavancin-loaded Palacos R and Simplex P cements, with different amounts of the antibiotic added to 40 g of cement powder: 0.125, 0.25, 0.5, 1.0, and 2.0 g. Telavancin elution was measured from each cement over 60 days. The efficacy of the eluted telavancin in eliminating four bacterial strains associated with PJI (MSSA, MRSA, and S. epidermidis) was determined. Mechanical tests, four-point bend, compression, and fracture toughness, were performed. In this in vitro study, the higher doses of telavancin increased telavancin release, and Palacos exhibited better elution than did Simplex. Similarly, the addition of 2 g of telavancin to the Palacos increased the efficacy of the ALBC for preventing bacterial colonization and biofilm formation. However, the mechanical performance of the bone cement containing telavancin was significantly reduced after wet curing, with flexural and compressive strength of the cements weakening. Moreover, Palacos that contained telavancin resulted in higher fracture toughness than did Simplex. Therefore, incorporating telavancin into Palacos for use in total joint replacement surgery demonstrated better performance than Simplex but further study is needed to improve the detrimental effects on mechanical properties." @default.
• W3204097783 created "2021-10-11" @default.
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• W3204097783 date "2021-12-01" @default.
• W3204097783 modified "2023-09-24" @default.
• W3204097783 title "Evaluation of telavancin-loaded bone cement: Elution, eluate activity, and mechanical properties" @default.
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• W3204097783 doi "https://doi.org/10.1016/j.mtla.2021.101239" @default.
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