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- W3204102344 abstract "Human immunodeficiency virus (HIV) attacks the immune system and weakens the ability to fight infections/disease. Furthermore, HIV infection confers approximately two-fold higher risk of cardiac events compared with the general population. The pathological mechanisms responsible for the increased incidence of cardiovascular disease in HIV patients are largely unknown. We hypothesized that increased oxidative stress and attenuated circulating levels of the cardioprotective gaseous signaling molecules, nitric oxide (NO), and hydrogen sulfide (H2S) were involved in the cardiovascular pathobiology observed in HIV patients. Plasma samples from both HIV patients and age-matched normal subjects were used for all assays. Oxidative stress was determined by analyzing the levels of advanced oxidation protein products (AOPP) and H2O2. Antioxidant levels were determined by measuring the levels of trolox equivalent capacity. ADMA, hs-CRP, and IL-6 were determined by using ELISA. The levels of H2S (free H2S and sulfane sulfur) and NO2 (nitrite) were determined in the plasma samples by using gas chromatography and HPLC, respectively. In the present study we observed a marked induction in the levels of oxidative stress and decreased antioxidant status in the plasma of HIV patients as compared with the controls. Circulating levels of the cardiovascular disease biomarkers: ADMA, hs-CRP (high-sensitivity C-reactive protein), and IL-6 were significantly increased in the circulatory system of HIV patients. The levels of both nitrite and H2S/sulfane sulfur were significantly reduced in the plasma of HIV patients as compared with normal subjects. Our data demonstrate significant increases in circulating biomarkers of oxidative stress and cardiovascular (CV) in conjunction with decreased bioavailability of H2S and NO in HIV patients. Diminished levels of these two cardioprotective gaseous signaling molecules may be involved in the pathogenesis of CV disease in the setting of HIV." @default.
- W3204102344 created "2021-10-11" @default.
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- W3204102344 creator A5091249769 @default.
- W3204102344 date "2021-09-28" @default.
- W3204102344 modified "2023-10-14" @default.
- W3204102344 title "Circulating Hydrogen Sulfide (H2S) and Nitric Oxide (NO) Levels Are Significantly Reduced in HIV Patients Concomitant with Increased Oxidative Stress Biomarkers" @default.
- W3204102344 cites W1511302815 @default.
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- W3204102344 cites W1967407881 @default.
- W3204102344 cites W1972339412 @default.
- W3204102344 cites W1979710206 @default.
- W3204102344 cites W1980461800 @default.
- W3204102344 cites W1991891777 @default.
- W3204102344 cites W1992444597 @default.
- W3204102344 cites W1993263198 @default.
- W3204102344 cites W1993316129 @default.
- W3204102344 cites W1994379392 @default.
- W3204102344 cites W1996020742 @default.
- W3204102344 cites W1997023449 @default.
- W3204102344 cites W1999466566 @default.
- W3204102344 cites W2005980540 @default.
- W3204102344 cites W2016168268 @default.
- W3204102344 cites W2016531059 @default.
- W3204102344 cites W2016901103 @default.
- W3204102344 cites W2025952153 @default.
- W3204102344 cites W2028516053 @default.
- W3204102344 cites W2028606217 @default.
- W3204102344 cites W2029603844 @default.
- W3204102344 cites W2039067102 @default.
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- W3204102344 cites W2054931962 @default.
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- W3204102344 cites W2162249283 @default.
- W3204102344 cites W2164189703 @default.
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- W3204102344 doi "https://doi.org/10.3390/jcm10194460" @default.
- W3204102344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8509794" @default.
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- W3204102344 hasPublicationYear "2021" @default.
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