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- W3204104795 abstract "Summary Malignant Pleural Mesothelioma (MPM) is an aggressive cancer with rising incidence and challenging clinical management. Using the largest series of whole-genome sequencing data integrated with transcriptomic and epigenomic data using multi-omic factor analysis, we demonstrate that MPM heterogeneity arises from four sources of variation: tumor cell morphology, ploidy, adaptive immune response, and CpG island methylator phenotype. Previous genomic studies focused on describing only the tumor cell morphology factor, although we robustly find the three other sources in all publicly available cohorts. We prove how these sources of variation explain the biological functions performed by the cancer cells, and how genomic events shape MPM molecular profiles. We show how these new sources of variation help understand the heterogeneity of the clinical behavior of MPM and drug responses measured in cell lines. These findings unearth the interplay between MPM functional biology and its genomic history, and ultimately, inform classification, prognostication and treatment. Graphical abstract" @default.
- W3204104795 created "2021-10-11" @default.
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- W3204104795 date "2021-09-29" @default.
- W3204104795 modified "2023-10-17" @default.
- W3204104795 title "Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analyses" @default.
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- W3204104795 cites W2069267068 @default.
- W3204104795 cites W2089037600 @default.
- W3204104795 cites W2103441770 @default.
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- W3204104795 cites W2165750757 @default.
- W3204104795 cites W2169903102 @default.
- W3204104795 cites W2173565120 @default.
- W3204104795 cites W2180481128 @default.
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- W3204104795 cites W2260951263 @default.
- W3204104795 cites W2275877493 @default.
- W3204104795 cites W2287191467 @default.
- W3204104795 cites W2291531085 @default.
- W3204104795 cites W2403874820 @default.