FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204105124> ?p ?o ?g. }

• W3204105124 endingPage "16555" @default.
• W3204105124 startingPage "16549" @default.
• W3204105124 abstract "The G-quadruplexes (G4s) formed in the PDGFR-β gene promoter are transcriptional modulators and amenable to small-molecule targeting. Berberine (BER), a clinically important natural isoquinoline alkaloid, has gained increasing attention due to its potential as anticancer drug. We previously showed that the PDGFR-β gene promoter forms a unique vacancy G4 (vG4) that can be filled in and stabilized by guanine metabolites, such as dGMP. Herein, we report the high-resolution NMR structure of a ternary complex of berberine bound to the dGMP-fill-in PDGFR-β vG4 in potassium solution. This is the first small-molecule complex structure of a fill-in vG4. This ternary complex has a 2:1:1 binding stoichiometry with a berberine molecule bound at each the 5'- and 3'-end of the 5'-dGMP-fill-in PDGFR-β vG4. Each berberine recruits the adjacent adenine residue from the 5'- or 3'-flanking sequence to form a quasi-triad plane that covers the external G-tetrad of the fill-in vG4, respectively. Significantly, berberine covers and stabilizes the fill-in dGMP. The binding of berberine involves both π-stacking and electrostatic interactions, and the fill-in dGMP is covered and well-protected by berberine. The NMR structure can guide rational design of berberine analogues that target the PDGFR-β vG4 or dGMP-fill-in vG4. Moreover, our structure provides a molecular basis for designing small-molecule guanine conjugates to target vG4s." @default.
• W3204105124 created "2021-10-11" @default.
• W3204105124 creator A5012642979 @default.
• W3204105124 creator A5030013482 @default.
• W3204105124 creator A5048808165 @default.
• W3204105124 date "2021-09-29" @default.
• W3204105124 modified "2023-10-14" @default.
• W3204105124 title "Solution Structure of Ternary Complex of Berberine Bound to a dGMP–Fill-In Vacancy G-Quadruplex Formed in the PDGFR-β Promoter" @default.
• W3204105124 cites W1513461363 @default.
• W3204105124 cites W1914649288 @default.
• W3204105124 cites W1982504159 @default.
• W3204105124 cites W1990635146 @default.
• W3204105124 cites W1994153742 @default.
• W3204105124 cites W1999601914 @default.
• W3204105124 cites W1999762006 @default.
• W3204105124 cites W2012006084 @default.
• W3204105124 cites W2029667189 @default.
• W3204105124 cites W2040051713 @default.
• W3204105124 cites W2043610498 @default.
• W3204105124 cites W2043720815 @default.
• W3204105124 cites W2051642566 @default.
• W3204105124 cites W2053854575 @default.
• W3204105124 cites W2059306569 @default.
• W3204105124 cites W2063270472 @default.
• W3204105124 cites W2078991002 @default.
• W3204105124 cites W2092424765 @default.
• W3204105124 cites W2097521277 @default.
• W3204105124 cites W2108763751 @default.
• W3204105124 cites W2143583668 @default.
• W3204105124 cites W2144108475 @default.
• W3204105124 cites W2155214429 @default.
• W3204105124 cites W2155773930 @default.
• W3204105124 cites W2158960002 @default.
• W3204105124 cites W2166592750 @default.
• W3204105124 cites W2171918265 @default.
• W3204105124 cites W2172060739 @default.
• W3204105124 cites W2229724153 @default.
• W3204105124 cites W2257749782 @default.
• W3204105124 cites W2258421680 @default.
• W3204105124 cites W2520749639 @default.
• W3204105124 cites W2528598904 @default.
• W3204105124 cites W2590327834 @default.
• W3204105124 cites W2591101673 @default.
• W3204105124 cites W2611414349 @default.
• W3204105124 cites W2730080362 @default.
• W3204105124 cites W2751110354 @default.
• W3204105124 cites W2807775040 @default.
• W3204105124 cites W2808136147 @default.
• W3204105124 cites W2883883147 @default.
• W3204105124 cites W2896637864 @default.
• W3204105124 cites W2948191632 @default.
• W3204105124 cites W2976449702 @default.
• W3204105124 cites W2982309704 @default.
• W3204105124 cites W2987179400 @default.
• W3204105124 cites W2990336210 @default.
• W3204105124 cites W2996688344 @default.
• W3204105124 cites W3008541456 @default.
• W3204105124 cites W3028359160 @default.
• W3204105124 cites W3029706921 @default.
• W3204105124 cites W3046176750 @default.
• W3204105124 cites W3163614504 @default.
• W3204105124 cites W4236973945 @default.
• W3204105124 cites W4247216591 @default.
• W3204105124 cites W4253198549 @default.
• W3204105124 doi "https://doi.org/10.1021/jacs.1c06200" @default.
• W3204105124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8626096" @default.
• W3204105124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34586799" @default.
• W3204105124 hasPublicationYear "2021" @default.
• W3204105124 type Work @default.
• W3204105124 sameAs 3204105124 @default.
• W3204105124 citedByCount "12" @default.
• W3204105124 countsByYear W32041051242022 @default.
• W3204105124 countsByYear W32041051242023 @default.
• W3204105124 crossrefType "journal-article" @default.
• W3204105124 hasAuthorship W3204105124A5012642979 @default.
• W3204105124 hasAuthorship W3204105124A5030013482 @default.
• W3204105124 hasAuthorship W3204105124A5048808165 @default.
• W3204105124 hasBestOaLocation W32041051242 @default.
• W3204105124 hasConcept C161624437 @default.
• W3204105124 hasConcept C178790620 @default.
• W3204105124 hasConcept C181199279 @default.
• W3204105124 hasConcept C185592680 @default.
• W3204105124 hasConcept C2780116568 @default.
• W3204105124 hasConcept C32909587 @default.
• W3204105124 hasConcept C552990157 @default.
• W3204105124 hasConcept C55493867 @default.
• W3204105124 hasConcept C71240020 @default.
• W3204105124 hasConcept C83762044 @default.
• W3204105124 hasConcept C86756495 @default.
• W3204105124 hasConceptScore W3204105124C161624437 @default.
• W3204105124 hasConceptScore W3204105124C178790620 @default.
• W3204105124 hasConceptScore W3204105124C181199279 @default.
• W3204105124 hasConceptScore W3204105124C185592680 @default.
• W3204105124 hasConceptScore W3204105124C2780116568 @default.
• W3204105124 hasConceptScore W3204105124C32909587 @default.
• W3204105124 hasConceptScore W3204105124C552990157 @default.
• W3204105124 hasConceptScore W3204105124C55493867 @default.
• W3204105124 hasConceptScore W3204105124C71240020 @default.

• next