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- W3204109301 abstract "Abstract The mammalian cerebrum performs high-level sensory perception, motor control and cognitive functions through highly specialized cortical and subcortical structures 1 . Recent surveys of mouse and human brains with single-cell transcriptomics 2–6 and high-throughput imaging technologies 7,8 have uncovered hundreds of neural cell types distributed in different brain regions, but the transcriptional regulatory programs that are responsible for the unique identity and function of each cell type remain unknown. Here we probe the accessible chromatin in more than 800,000 individual nuclei from 45 regions that span the adult mouse isocortex, olfactory bulb, hippocampus and cerebral nuclei, and use the resulting data to map the state of 491,818 candidate cis -regulatory DNA elements in 160 distinct cell types. We find high specificity of spatial distribution for not only excitatory neurons, but also most classes of inhibitory neurons and a subset of glial cell types. We characterize the gene regulatory sequences associated with the regional specificity within these cell types. We further link a considerable fraction of the cis -regulatory elements to putative target genes expressed in diverse cerebral cell types and predict transcriptional regulators that are involved in a broad spectrum of molecular and cellular pathways in different neuronal and glial cell populations. Our results provide a foundation for comprehensive analysis of gene regulatory programs of the mammalian brain and assist in the interpretation of noncoding risk variants associated with various neurological diseases and traits in humans." @default.
- W3204109301 created "2021-10-11" @default.
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- W3204109301 date "2021-10-06" @default.
- W3204109301 modified "2023-10-18" @default.
- W3204109301 title "An atlas of gene regulatory elements in adult mouse cerebrum" @default.
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- W3204109301 cites W1735309556 @default.
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- W3204109301 cites W1979283544 @default.
- W3204109301 cites W1979594866 @default.
- W3204109301 cites W1984827465 @default.
- W3204109301 cites W1984883254 @default.
- W3204109301 cites W1989590412 @default.
- W3204109301 cites W1991543373 @default.
- W3204109301 cites W2005986419 @default.
- W3204109301 cites W2013934108 @default.
- W3204109301 cites W2014677321 @default.
- W3204109301 cites W2016015848 @default.
- W3204109301 cites W2018363492 @default.
- W3204109301 cites W2021341670 @default.
- W3204109301 cites W2033201031 @default.
- W3204109301 cites W2040534665 @default.
- W3204109301 cites W2040868835 @default.
- W3204109301 cites W2042930277 @default.
- W3204109301 cites W2070050178 @default.
- W3204109301 cites W2101357408 @default.
- W3204109301 cites W2102619694 @default.
- W3204109301 cites W2103441770 @default.
- W3204109301 cites W2117757143 @default.
- W3204109301 cites W2121147886 @default.
- W3204109301 cites W2123491442 @default.
- W3204109301 cites W2124295970 @default.
- W3204109301 cites W2133707124 @default.
- W3204109301 cites W2134861134 @default.
- W3204109301 cites W2135046848 @default.
- W3204109301 cites W2135159454 @default.
- W3204109301 cites W2145191876 @default.
- W3204109301 cites W2151718948 @default.
- W3204109301 cites W2153860431 @default.
- W3204109301 cites W2159114004 @default.
- W3204109301 cites W2165685007 @default.
- W3204109301 cites W2166670234 @default.
- W3204109301 cites W2169674658 @default.
- W3204109301 cites W2171808845 @default.
- W3204109301 cites W2231058499 @default.
- W3204109301 cites W2231935239 @default.
- W3204109301 cites W2259938310 @default.
- W3204109301 cites W2346626662 @default.
- W3204109301 cites W2465667391 @default.
- W3204109301 cites W2477863367 @default.
- W3204109301 cites W2491330173 @default.
- W3204109301 cites W2510387549 @default.
- W3204109301 cites W2544485223 @default.
- W3204109301 cites W2550718412 @default.
- W3204109301 cites W2558411436 @default.
- W3204109301 cites W2571503386 @default.
- W3204109301 cites W2581259096 @default.
- W3204109301 cites W2587889281 @default.
- W3204109301 cites W2608920382 @default.
- W3204109301 cites W2735404270 @default.
- W3204109301 cites W2740637836 @default.
- W3204109301 cites W2744040456 @default.
- W3204109301 cites W2753172052 @default.
- W3204109301 cites W2765256236 @default.
- W3204109301 cites W2766078734 @default.
- W3204109301 cites W2790768464 @default.
- W3204109301 cites W2791662659 @default.
- W3204109301 cites W2794373801 @default.