Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204114926> ?p ?o ?g. }
- W3204114926 abstract "Neuroinflammation is a common feature of many neurodegenerative diseases. It fosters a dysfunctional neuron-microglia-astrocyte crosstalk that, in turn, maintains microglial cells in a perniciously reactive state that often enhances neuronal damage. The molecular components that mediate this critical communication are not fully explored. Here, we show that secreted frizzled-related protein 1 (SFRP1), a multifunctional regulator of cell-to-cell communication, is part of the cellular crosstalk underlying neuroinflammation. In mouse models of acute and chronic neuroinflammation, SFRP1, largely astrocyte-derived, promotes and sustains microglial activation, and thus a chronic inflammatory state. SFRP1 promotes the upregulation of components of the hypoxia-induced factor-dependent inflammatory pathway and, to a lower extent, of those downstream of the nuclear factor-kappa B. We thus propose that SFRP1 acts as an astrocyte-to-microglia amplifier of neuroinflammation, representing a potential valuable therapeutic target for counteracting the harmful effect of chronic inflammation in several neurodegenerative diseases." @default.
- W3204114926 created "2021-10-11" @default.
- W3204114926 creator A5002495343 @default.
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- W3204114926 creator A5079082664 @default.
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- W3204114926 creator A5088412281 @default.
- W3204114926 date "2021-09-27" @default.
- W3204114926 modified "2023-10-16" @default.
- W3204114926 title "SFRP1 modulates astrocyte‐to‐microglia crosstalk in acute and chronic neuroinflammation" @default.
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