FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204120325> ?p ?o ?g. }

• W3204120325 abstract "Streptococcus intermedius occasionally causes brain abscesses that can be life-threatening, requiring prompt antibiotic and neurosurgical treatment. The source is often dental, and it may spread to the eye or the brain parenchyma. We report the case of a 34-year-old man with signs of apical periodontitis, endophthalmitis, and multiple brain abscesses caused by Streptococcus intermedius. Initial treatment with meropenem and vancomycin was unsuccessful due to subtherapeutic concentrations, despite recommended dosages. Adequate concentrations could be reached only after increasing the dose of meropenem to 16 g/day and vancomycin to 1.5 g × 4. The patient exhibited high creatinine clearance consistent with augmented renal clearance, although iohexol and cystatin C clearances were normal. Plasma free vancomycin clearance followed that of creatinine. A one-day dose of trimethoprim-sulfamethoxazole led to an increase in serum creatinine and a decrease in both creatinine and urea clearances. These results indicate that increased tubular secretion of the drugs was the cause of suboptimal antibiotic treatment. The patient eventually recovered, but his left eye needed enucleation. Our case illustrates that augmented renal clearance can jeopardize the treatment of serious bacterial infections and that high doses of antibiotics are needed to achieve therapeutic concentrations in such cases. The mechanisms for regulation of kidney tubular transporters of creatinine, urea, vancomycin, and meropenem in critically ill patients are discussed." @default.
• W3204120325 created "2021-10-11" @default.
• W3204120325 creator A5000360454 @default.
• W3204120325 creator A5005872270 @default.
• W3204120325 creator A5010451986 @default.
• W3204120325 creator A5022482611 @default.
• W3204120325 creator A5023680339 @default.
• W3204120325 creator A5032946030 @default.
• W3204120325 creator A5035225306 @default.
• W3204120325 creator A5078628198 @default.
• W3204120325 creator A5083121202 @default.
• W3204120325 date "2021-10-06" @default.
• W3204120325 modified "2023-10-17" @default.
• W3204120325 title "Case Report: Subtherapeutic Vancomycin and Meropenem Concentrations due to Augmented Renal Clearance in a Patient With Intracranial Infection Caused by Streptococcus intermedius" @default.
• W3204120325 cites W1571331508 @default.
• W3204120325 cites W1603121691 @default.
• W3204120325 cites W1973795734 @default.
• W3204120325 cites W1978352074 @default.
• W3204120325 cites W1983508148 @default.
• W3204120325 cites W2025782085 @default.
• W3204120325 cites W2041424189 @default.
• W3204120325 cites W2041704827 @default.
• W3204120325 cites W2051760128 @default.
• W3204120325 cites W2054105805 @default.
• W3204120325 cites W2066344356 @default.
• W3204120325 cites W2078013380 @default.
• W3204120325 cites W2086702076 @default.
• W3204120325 cites W2092021127 @default.
• W3204120325 cites W2100510417 @default.
• W3204120325 cites W2109178387 @default.
• W3204120325 cites W2118992949 @default.
• W3204120325 cites W2133120422 @default.
• W3204120325 cites W2137640977 @default.
• W3204120325 cites W2144991343 @default.
• W3204120325 cites W2163578189 @default.
• W3204120325 cites W2168319665 @default.
• W3204120325 cites W2172197084 @default.
• W3204120325 cites W2405074900 @default.
• W3204120325 cites W2754662782 @default.
• W3204120325 cites W2786832455 @default.
• W3204120325 cites W2788693368 @default.
• W3204120325 cites W2791838768 @default.
• W3204120325 cites W2890474169 @default.
• W3204120325 cites W2896895305 @default.
• W3204120325 cites W2913445675 @default.
• W3204120325 cites W2949909561 @default.
• W3204120325 cites W2970018360 @default.
• W3204120325 cites W3010709136 @default.
• W3204120325 cites W3011496947 @default.
• W3204120325 cites W3012260518 @default.
• W3204120325 cites W3014137123 @default.
• W3204120325 cites W3035919364 @default.
• W3204120325 cites W3041822152 @default.
• W3204120325 cites W3136324344 @default.
• W3204120325 cites W4230586510 @default.
• W3204120325 cites W4243937179 @default.
• W3204120325 cites W4244256062 @default.
• W3204120325 cites W4381850888 @default.
• W3204120325 cites W842625169 @default.
• W3204120325 doi "https://doi.org/10.3389/fphar.2021.728075" @default.
• W3204120325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8527190" @default.
• W3204120325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34690767" @default.
• W3204120325 hasPublicationYear "2021" @default.
• W3204120325 type Work @default.
• W3204120325 sameAs 3204120325 @default.
• W3204120325 citedByCount "5" @default.
• W3204120325 countsByYear W32041203252022 @default.
• W3204120325 countsByYear W32041203252023 @default.
• W3204120325 crossrefType "journal-article" @default.
• W3204120325 hasAuthorship W3204120325A5000360454 @default.
• W3204120325 hasAuthorship W3204120325A5005872270 @default.
• W3204120325 hasAuthorship W3204120325A5010451986 @default.
• W3204120325 hasAuthorship W3204120325A5022482611 @default.
• W3204120325 hasAuthorship W3204120325A5023680339 @default.
• W3204120325 hasAuthorship W3204120325A5032946030 @default.
• W3204120325 hasAuthorship W3204120325A5035225306 @default.
• W3204120325 hasAuthorship W3204120325A5078628198 @default.
• W3204120325 hasAuthorship W3204120325A5083121202 @default.
• W3204120325 hasBestOaLocation W32041203251 @default.
• W3204120325 hasConcept C126322002 @default.
• W3204120325 hasConcept C141071460 @default.
• W3204120325 hasConcept C159641895 @default.
• W3204120325 hasConcept C2776236688 @default.
• W3204120325 hasConcept C2777035434 @default.
• W3204120325 hasConcept C2778980435 @default.
• W3204120325 hasConcept C2779375183 @default.
• W3204120325 hasConcept C2779489039 @default.
• W3204120325 hasConcept C2780306776 @default.
• W3204120325 hasConcept C501593827 @default.
• W3204120325 hasConcept C523546767 @default.
• W3204120325 hasConcept C54355233 @default.
• W3204120325 hasConcept C71924100 @default.
• W3204120325 hasConcept C86803240 @default.
• W3204120325 hasConcept C89423630 @default.
• W3204120325 hasConcept C94665300 @default.
• W3204120325 hasConcept C98274493 @default.
• W3204120325 hasConceptScore W3204120325C126322002 @default.
• W3204120325 hasConceptScore W3204120325C141071460 @default.
• W3204120325 hasConceptScore W3204120325C159641895 @default.
• W3204120325 hasConceptScore W3204120325C2776236688 @default.

• next