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• W3204120601 abstract "Radiolabeled antibodies and peptides have been widely used for molecular imaging and targeted radiopharmaceutical therapy over the course of many decades, for the purposes of detection and treatment of catastrophic diseases, mainly cancer. Although these agents were initially expected to be “magic bullets” for targeting cancer, both antibodies and peptides have major, characteristic limitations. Thus, considerable effort has been placed on modification of these agents to improve pharmacokinetics, tumor uptake, and whole-body clearance. Monoclonal antibodies typically have high tumor uptake; however, their long residence time in blood and slow and uneven uptake in tumors can compromise imaging contrast and result in dose-limiting bone marrow toxicity associated with radioimmunotherapy. Strategies designed to overcome these barriers have included the engineering of antibody fragments and smaller, nonnatural constructs. On the other hand, radioactive peptides typically target tumors more rapidly and have more uniform intratumoral distributions, with concomitant and rapid elimination of the agent via renal excretion. These properties often provide superior imaging contrast. However, tumor uptake of peptides is typically lower than that of antibodies, and renal clearance may result in toxicity to the kidneys during radiopharmaceutical therapy. Thus, the search for improvements in peptide targeting often focuses on the development of pharmacokinetic modifiers. Antibody pretargeting is an approach designed to combine the favorable properties of both antibodies and peptides, while eliminating the undesired effects of each. In pretargeting, a nonradioactive antibody is administered first and allowed to reach its maximum tumor uptake. Then a radioactive small molecule that binds with high affinity and specificity to the antibody is given subsequently. This strategy is intended to combine the high tumor uptake of antibodies with the rapid elimination of small molecules, in an effort to improve imaging contrast, normal organ toxicity, and therapeutic efficacy. Recent advancements in the use of antibodies and peptides for cancer imaging and therapy include targeted magnetic contrast agents and nanoparticle-based platforms. There is also widespread interest in optical technologies, with the application of antibodies and peptides conjugated to dyes or quantum dots for fluorescence imaging. Taken together, recent progress to expand strategies for antibody- and peptide-based molecular imaging and targeted radiopharmaceutical therapy has the potential to advance detection and treatment of cancers on a molecular level and in a personalized medicine approach." @default.
• W3204120601 created "2021-10-11" @default.
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• W3204120601 date "2021-01-01" @default.
• W3204120601 modified "2023-09-24" @default.
• W3204120601 title "Targeted Antibodies and Peptides" @default.
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• W3204120601 doi "https://doi.org/10.1016/b978-0-12-816386-3.00022-3" @default.
• W3204120601 hasPublicationYear "2021" @default.
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