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- W3204120913 endingPage "2020" @default.
- W3204120913 startingPage "2020" @default.
- W3204120913 abstract "Paramyxoviruses, negative-sense single-stranded RNA viruses, pose a critical threat to human public health. Currently, 78 species, 17 genera, and 4 subfamilies of paramyxoviruses are harbored by multiple natural reservoirs, including rodents, bats, birds, reptiles, and fish. Henipaviruses are critical zoonotic pathogens that cause severe acute respiratory distress and neurological diseases in humans. Using reverse transcription-polymerase chain reaction, 115 Crocidura species individuals were examined for the prevalence of paramyxovirus infections. Paramyxovirus RNA was observed in 26 (22.6%) shrews collected at five trapping sites, Republic of Korea. Herein, we report two genetically distinct novel paramyxoviruses (genus: Henipavirus): Gamak virus (GAKV) and Daeryong virus (DARV) isolated from C. lasiura and C. shantungensis, respectively. Two GAKVs and one DARV were nearly completely sequenced using next-generation sequencing. GAKV and DARV contain six genes (3'-N-P-M-F-G-L-5') with genome sizes of 18,460 nucleotides and 19,471 nucleotides, respectively. The phylogenetic inference demonstrated that GAKV and DARV form independent genetic lineages of Henipavirus in Crocidura species. GAKV-infected human lung epithelial cells elicited the induction of type I/III interferons, interferon-stimulated genes, and proinflammatory cytokines. In conclusion, this study contributes further understandings of the molecular prevalence, genetic characteristics and diversity, and zoonotic potential of novel paramyxoviruses in shrews." @default.
- W3204120913 created "2021-10-11" @default.
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- W3204120913 date "2021-10-07" @default.
- W3204120913 modified "2023-10-09" @default.
- W3204120913 title "Discovery and Genetic Characterization of Novel Paramyxoviruses Related to the Genus Henipavirus in Crocidura Species in the Republic of Korea" @default.
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- W3204120913 doi "https://doi.org/10.3390/v13102020" @default.
- W3204120913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8537881" @default.
- W3204120913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34696450" @default.
- W3204120913 hasPublicationYear "2021" @default.
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