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- W3204123225 abstract "Aim: The pharmacokinetic study of the brimonidine tartrate in situ gel in the anterior chamber of the rabbit eye was studied by microdialysis technique, and samples were analyzed by HPLC-MS/MS. Materials & methods: It was monitored in ESI mode at transition 291.9→212.0 and 296.0→216.0 for brimonidine and internal standard, respectively. Acetonitrile and 0.1% aqueous formic acid (50:50, v/v) were used as the mobile phase at 0.4 ml/min. Results & conclusion: It showed a good linear correlation between 5 and 5000 ng/ml in microdialysis solution, and the inter- and intra-day precision (relative standard deviation) was less than 4.0%. The pharmacokinetic study showed that the AUC(0-t) of in situ gel was 3.5-times than that of eyedrops, which significantly improve the bioavailability of brimonidine." @default.
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- W3204123225 date "2021-10-01" @default.
- W3204123225 modified "2023-10-14" @default.
- W3204123225 title "HPLC–MS/MS studies of brimonidine in rabbit aqueous humor by microdialysis" @default.
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- W3204123225 doi "https://doi.org/10.4155/bio-2021-0127" @default.
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