FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204125093> ?p ?o ?g. }

• W3204125093 endingPage "1392" @default.
• W3204125093 startingPage "1392" @default.
• W3204125093 abstract "Osteoporotic vertebral fractures often necessitate fusion surgery, with high rates of implant failure. We present a novel bioactive composite of calcium phosphate cement (CPC) and the collagen I mimetic P-15 for pedicle screw augmentation in osteoporotic bone. Methods involved expression analysis of osteogenesis-related genes during osteoblastic differentiation by RT-PCR and immunostaining of osteopontin and Ca2+ deposits. Untreated and decalcified sheep vertebrae were utilized for linear pullout testing of pedicle screws. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DEXA). Expression of ALPI II (p < 0.0001), osteopontin (p < 0.0001), RUNX2 (p < 0.0001), and osteocalcin (p < 0.0001) was upregulated after co-culture of MSC with CPC-P-15. BMD was decreased by 28.75% ± 2.6%. Pullout loads in untreated vertebrae were 1405 ± 6 N (p < 0.001) without augmentation, 2010 ± 168 N (p < 0.0001) after augmentation with CPC-P-15, and 2112 ± 98 N (p < 0.0001) with PMMA. In decalcified vertebrae, pullout loads were 828 ± 66 N (p < 0.0001) without augmentation, 1324 ± 712 N (p = 0.04) with PMMA, and 1252 ± 131 N (p < 0.0078) with CPC-P-15. CPC-P-15 induces osteoblastic differentiation of human MES and improves pullout resistance of pedicle screws in osteoporotic and non-osteoporotic bone." @default.
• W3204125093 created "2021-10-11" @default.
• W3204125093 creator A5002788152 @default.
• W3204125093 creator A5036762150 @default.
• W3204125093 creator A5043201015 @default.
• W3204125093 creator A5049913460 @default.
• W3204125093 creator A5053405743 @default.
• W3204125093 creator A5058697846 @default.
• W3204125093 creator A5078759014 @default.
• W3204125093 creator A5086608452 @default.
• W3204125093 date "2021-10-04" @default.
• W3204125093 modified "2023-09-26" @default.
• W3204125093 title "Novel Biodegradable Composite of Calcium Phosphate Cement and the Collagen I Mimetic P-15 for Pedicle Screw Augmentation in Osteoporotic Bone" @default.
• W3204125093 cites W1969345791 @default.
• W3204125093 cites W1970663890 @default.
• W3204125093 cites W1984650831 @default.
• W3204125093 cites W1993147295 @default.
• W3204125093 cites W1993977410 @default.
• W3204125093 cites W1998991071 @default.
• W3204125093 cites W2001277837 @default.
• W3204125093 cites W2010452409 @default.
• W3204125093 cites W2033237160 @default.
• W3204125093 cites W2043758876 @default.
• W3204125093 cites W2047937058 @default.
• W3204125093 cites W2048121149 @default.
• W3204125093 cites W2049099898 @default.
• W3204125093 cites W2055055677 @default.
• W3204125093 cites W2060105026 @default.
• W3204125093 cites W2063191538 @default.
• W3204125093 cites W2064243386 @default.
• W3204125093 cites W2066626719 @default.
• W3204125093 cites W2074044220 @default.
• W3204125093 cites W2078005656 @default.
• W3204125093 cites W2081258070 @default.
• W3204125093 cites W2085372344 @default.
• W3204125093 cites W2104879247 @default.
• W3204125093 cites W2124900413 @default.
• W3204125093 cites W2145115255 @default.
• W3204125093 cites W2145830993 @default.
• W3204125093 cites W2149967181 @default.
• W3204125093 cites W2163341100 @default.
• W3204125093 cites W2166473629 @default.
• W3204125093 cites W2327824277 @default.
• W3204125093 cites W2524169823 @default.
• W3204125093 cites W2534030175 @default.
• W3204125093 cites W2558470533 @default.
• W3204125093 cites W2599867508 @default.
• W3204125093 cites W2604546486 @default.
• W3204125093 cites W2772046316 @default.
• W3204125093 cites W2777648965 @default.
• W3204125093 cites W2792559472 @default.
• W3204125093 cites W2795071394 @default.
• W3204125093 cites W2884374723 @default.
• W3204125093 cites W2906853630 @default.
• W3204125093 cites W2950009095 @default.
• W3204125093 cites W2988161887 @default.
• W3204125093 cites W3122371833 @default.
• W3204125093 cites W4292330637 @default.
• W3204125093 doi "https://doi.org/10.3390/biomedicines9101392" @default.
• W3204125093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8533375" @default.
• W3204125093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34680509" @default.
• W3204125093 hasPublicationYear "2021" @default.
• W3204125093 type Work @default.
• W3204125093 sameAs 3204125093 @default.
• W3204125093 citedByCount "4" @default.
• W3204125093 countsByYear W32041250932022 @default.
• W3204125093 countsByYear W32041250932023 @default.
• W3204125093 crossrefType "journal-article" @default.
• W3204125093 hasAuthorship W3204125093A5002788152 @default.
• W3204125093 hasAuthorship W3204125093A5036762150 @default.
• W3204125093 hasAuthorship W3204125093A5043201015 @default.
• W3204125093 hasAuthorship W3204125093A5049913460 @default.
• W3204125093 hasAuthorship W3204125093A5053405743 @default.
• W3204125093 hasAuthorship W3204125093A5058697846 @default.
• W3204125093 hasAuthorship W3204125093A5078759014 @default.
• W3204125093 hasAuthorship W3204125093A5086608452 @default.
• W3204125093 hasBestOaLocation W32041250931 @default.
• W3204125093 hasConcept C105702510 @default.
• W3204125093 hasConcept C126322002 @default.
• W3204125093 hasConcept C131075544 @default.
• W3204125093 hasConcept C141071460 @default.
• W3204125093 hasConcept C160160445 @default.
• W3204125093 hasConcept C181199279 @default.
• W3204125093 hasConcept C185592680 @default.
• W3204125093 hasConcept C199343813 @default.
• W3204125093 hasConcept C202751555 @default.
• W3204125093 hasConcept C204232928 @default.
• W3204125093 hasConcept C2776363554 @default.
• W3204125093 hasConcept C2776541429 @default.
• W3204125093 hasConcept C2776886416 @default.
• W3204125093 hasConcept C2778260815 @default.
• W3204125093 hasConcept C2780804394 @default.
• W3204125093 hasConcept C2781411149 @default.
• W3204125093 hasConcept C4224716 @default.
• W3204125093 hasConcept C519063684 @default.
• W3204125093 hasConcept C55493867 @default.
• W3204125093 hasConcept C71924100 @default.
• W3204125093 hasConcept C8337478 @default.

• next