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- W3204125301 abstract "Stroke is the third most common disease all over the world, which is regarded as a hotspot in medical research because of its high mortality and morbidity. Stroke, especially ischemic stroke, causes severe neural cell death, and no effective therapy is currently available for neuroregeneration after stroke. Although many therapies have been shown to be effective in preclinical studies of ischemic stroke, almost none of them passed clinical trials, and the reasons for most failures have not been well identified. In this review, we focus on several novel methods, such as traditional Chinese medicine, stem cell therapy, and exosomes that have not been used for ischemic stroke till recent decades. We summarize the proposed basic mechanisms underlying these therapies and related clinical results, discussing advantages and current limitations for each therapy emphatically. Based on the limitations such as side effects, narrow therapeutic window, and less accumulation at the injury region, structure transformation and drug combination are subsequently applied, providing a deep understanding to develop effective treatment strategies for ischemic stroke in the near future." @default.
- W3204125301 created "2021-10-11" @default.
- W3204125301 creator A5009180448 @default.
- W3204125301 creator A5036673866 @default.
- W3204125301 creator A5041664829 @default.
- W3204125301 creator A5042301918 @default.
- W3204125301 creator A5047933354 @default.
- W3204125301 creator A5081065929 @default.
- W3204125301 date "2021-09-30" @default.
- W3204125301 modified "2023-10-17" @default.
- W3204125301 title "Challenges and Improvements of Novel Therapies for Ischemic Stroke" @default.
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