FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204127007> ?p ?o ?g. }

• W3204127007 endingPage "108787" @default.
• W3204127007 startingPage "108787" @default.
• W3204127007 abstract "Recently, we reported β-cleavage of the prion protein (PrPC) in human ocular tissues. Here, we explored whether this is unique to the human eye, and its functional implications. A comparison of the cleavage pattern of PrPC in human ocular tissues with common nocturnal and diurnal animals revealed mainly β-cleavage in humans, and mostly full-length PrPC in animal retinas. Soluble FL PrPC and N-terminal fragment (N2) released from β-cleavage was observed in the aqueous and vitreous humor (AH & VH). Expression of human PrPC in ARPE-19 cells, a human retinal pigmented epithelial cell line, also showed β-cleaved PrPC. Surprisingly, β-cleavage was not altered by a variety of insults, including oxidative stress, suggesting a unique role of this cleavage in the human eye. It is likely that β-cleaved C- or N-terminal fragments of PrPC protect from various insults unique to the human eye. On the contrary, β-cleaved C-terminus of PrPC is susceptible to conversion to the pathological PrP-scrapie form, and includes the binding sites for β1-integrin and amyloid-β, molecules implicated in several ocular disorders. Considering the species and tissue-specific cleavage of PrPC, our data suggest re-evaluation of prion infectivity and other ocular disorders of the human eye conducted in mouse models." @default.
• W3204127007 created "2021-10-11" @default.
• W3204127007 creator A5016856377 @default.
• W3204127007 creator A5019678268 @default.
• W3204127007 creator A5034062607 @default.
• W3204127007 creator A5038841833 @default.
• W3204127007 creator A5040694194 @default.
• W3204127007 creator A5090786265 @default.
• W3204127007 creator A5091474272 @default.
• W3204127007 date "2021-11-01" @default.
• W3204127007 modified "2023-10-15" @default.
• W3204127007 title "β-Cleavage of the prion protein in the human eye: Implications for the spread of infectious prions and human ocular disorders" @default.
• W3204127007 cites W1183792589 @default.
• W3204127007 cites W1470987356 @default.
• W3204127007 cites W1548489625 @default.
• W3204127007 cites W1580230845 @default.
• W3204127007 cites W158846700 @default.
• W3204127007 cites W1592486646 @default.
• W3204127007 cites W1900120281 @default.
• W3204127007 cites W1950509877 @default.
• W3204127007 cites W1971107875 @default.
• W3204127007 cites W1980042430 @default.
• W3204127007 cites W1983345119 @default.
• W3204127007 cites W1998339301 @default.
• W3204127007 cites W2000507134 @default.
• W3204127007 cites W2002466165 @default.
• W3204127007 cites W2007440356 @default.
• W3204127007 cites W2012222860 @default.
• W3204127007 cites W2013618043 @default.
• W3204127007 cites W2014256366 @default.
• W3204127007 cites W2015047834 @default.
• W3204127007 cites W2016170408 @default.
• W3204127007 cites W2024580375 @default.
• W3204127007 cites W2026299157 @default.
• W3204127007 cites W2032338659 @default.
• W3204127007 cites W2032500403 @default.
• W3204127007 cites W2033893165 @default.
• W3204127007 cites W2037152161 @default.
• W3204127007 cites W2046950900 @default.
• W3204127007 cites W2049437984 @default.
• W3204127007 cites W2054088381 @default.
• W3204127007 cites W2055042213 @default.
• W3204127007 cites W2058963589 @default.
• W3204127007 cites W2063890956 @default.
• W3204127007 cites W2067417543 @default.
• W3204127007 cites W2068547311 @default.
• W3204127007 cites W2073472657 @default.
• W3204127007 cites W2077657292 @default.
• W3204127007 cites W2082179247 @default.
• W3204127007 cites W2083160536 @default.
• W3204127007 cites W2085322752 @default.
• W3204127007 cites W2093840007 @default.
• W3204127007 cites W2127342236 @default.
• W3204127007 cites W2149438882 @default.
• W3204127007 cites W2149723426 @default.
• W3204127007 cites W2166019856 @default.
• W3204127007 cites W2202164390 @default.
• W3204127007 cites W2204004844 @default.
• W3204127007 cites W2317853150 @default.
• W3204127007 cites W2324660492 @default.
• W3204127007 cites W2362972505 @default.
• W3204127007 cites W2406794861 @default.
• W3204127007 cites W2408923606 @default.
• W3204127007 cites W2515831916 @default.
• W3204127007 cites W2521030228 @default.
• W3204127007 cites W2577723374 @default.
• W3204127007 cites W2595394074 @default.
• W3204127007 cites W2595686910 @default.
• W3204127007 cites W2604252203 @default.
• W3204127007 cites W2611707378 @default.
• W3204127007 cites W2724145778 @default.
• W3204127007 cites W2750502478 @default.
• W3204127007 cites W2750773993 @default.
• W3204127007 cites W2793740592 @default.
• W3204127007 cites W2795650877 @default.
• W3204127007 cites W2805660344 @default.
• W3204127007 cites W2806462251 @default.
• W3204127007 cites W2807635362 @default.
• W3204127007 cites W2894058082 @default.
• W3204127007 cites W2898089705 @default.
• W3204127007 cites W2901005536 @default.
• W3204127007 cites W2921406196 @default.
• W3204127007 cites W2950278975 @default.
• W3204127007 cites W2972542992 @default.
• W3204127007 cites W2993960909 @default.
• W3204127007 cites W3011425392 @default.
• W3204127007 cites W3014182756 @default.
• W3204127007 cites W3035625320 @default.
• W3204127007 cites W3081062199 @default.
• W3204127007 cites W3090170642 @default.
• W3204127007 cites W3111575761 @default.
• W3204127007 cites W3122970152 @default.
• W3204127007 doi "https://doi.org/10.1016/j.exer.2021.108787" @default.
• W3204127007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8608713" @default.
• W3204127007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34624335" @default.
• W3204127007 hasPublicationYear "2021" @default.
• W3204127007 type Work @default.
• W3204127007 sameAs 3204127007 @default.

• next