FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204135709> ?p ?o ?g. }

• W3204135709 endingPage "71" @default.
• W3204135709 startingPage "62" @default.
• W3204135709 abstract "von Willebrand disease (VWD) is associated with significant morbidity as a result of excessive mucocutaneous bleeding. Early diagnosis and treatment are important to prevent and treat these symptoms. We systematically reviewed the accuracy of diagnostic tests using different cutoff values of von Willebrand factor antigen (VWF:Ag) and platelet-dependent von Willebrand factor (VWF) activity assays in the diagnosis of VWD. We searched Cochrane Central Register for Controlled Trials, MEDLINE, and Embase databases for eligible studies. We pooled estimates of sensitivity and specificity and reported patient-important outcomes when relevant. This review included 21 studies that evaluated VWD diagnosis. The results showed low certainty in the evidence for a net health benefit from reconsidering the diagnosis of VWD vs removing the disease diagnosis in patients with VWF levels that have normalized with age. For the diagnosis of type 1 VWD, VWF sequence variants were detected in 75% to 82% of patients with VWF:Ag < 0.30 IU/mL and in 44% to 60% of patients with VWF:Ag between 0.30 and 0.50 IU/mL. A sensitivity of 0.90 (95% confidence interval [CI], 0.83-0.94) and a specificity of 0.91 (95% CI, 0.76-0.97) were observed for a platelet-dependent VWF activity/VWF:Ag ratio < 0.7 in detecting type 2 VWD (moderate certainty in the test accuracy results). VWF:Ag and platelet-dependent activity are continuous variables that are associated with an increase in bleeding risk with decreasing levels. This systematic review shows that using a VWF activity/VWF:Ag ratio < 0.7 vs lower cutoff levels in patients with an abnormal initial VWD screen is more accurate for the diagnosis of type 2 VWD." @default.
• W3204135709 created "2021-10-11" @default.
• W3204135709 creator A5007517961 @default.
• W3204135709 creator A5007697163 @default.
• W3204135709 creator A5009809054 @default.
• W3204135709 creator A5010330151 @default.
• W3204135709 creator A5013439509 @default.
• W3204135709 creator A5014111921 @default.
• W3204135709 creator A5016285611 @default.
• W3204135709 creator A5018546198 @default.
• W3204135709 creator A5022674970 @default.
• W3204135709 creator A5023823647 @default.
• W3204135709 creator A5027617827 @default.
• W3204135709 creator A5032174515 @default.
• W3204135709 creator A5040172071 @default.
• W3204135709 creator A5041823391 @default.
• W3204135709 creator A5042048122 @default.
• W3204135709 creator A5045102610 @default.
• W3204135709 creator A5062313473 @default.
• W3204135709 creator A5066821523 @default.
• W3204135709 creator A5067205817 @default.
• W3204135709 creator A5073181970 @default.
• W3204135709 creator A5076531502 @default.
• W3204135709 creator A5077753793 @default.
• W3204135709 creator A5081768317 @default.
• W3204135709 date "2021-12-30" @default.
• W3204135709 modified "2023-10-13" @default.
• W3204135709 title "von Willebrand factor levels in the diagnosis of von Willebrand disease: a systematic review and meta-analysis" @default.
• W3204135709 cites W1534508763 @default.
• W3204135709 cites W1598628534 @default.
• W3204135709 cites W1735696209 @default.
• W3204135709 cites W1990942416 @default.
• W3204135709 cites W1994158325 @default.
• W3204135709 cites W2005501262 @default.
• W3204135709 cites W2006378116 @default.
• W3204135709 cites W2026401041 @default.
• W3204135709 cites W2028920411 @default.
• W3204135709 cites W2028949333 @default.
• W3204135709 cites W2064557393 @default.
• W3204135709 cites W2072841269 @default.
• W3204135709 cites W2077167348 @default.
• W3204135709 cites W2078744902 @default.
• W3204135709 cites W2088226295 @default.
• W3204135709 cites W2089009990 @default.
• W3204135709 cites W2102874712 @default.
• W3204135709 cites W2107638293 @default.
• W3204135709 cites W2110035686 @default.
• W3204135709 cites W2122778009 @default.
• W3204135709 cites W2141209830 @default.
• W3204135709 cites W2260744446 @default.
• W3204135709 cites W2549291642 @default.
• W3204135709 cites W2742036276 @default.
• W3204135709 cites W2756016513 @default.
• W3204135709 cites W2766783631 @default.
• W3204135709 cites W2790625659 @default.
• W3204135709 cites W2800791231 @default.
• W3204135709 cites W2804578743 @default.
• W3204135709 cites W2991156546 @default.
• W3204135709 cites W3120545968 @default.
• W3204135709 cites W3121114429 @default.
• W3204135709 cites W82496709 @default.
• W3204135709 doi "https://doi.org/10.1182/bloodadvances.2021005430" @default.
• W3204135709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34610118" @default.
• W3204135709 hasPublicationYear "2021" @default.
• W3204135709 type Work @default.
• W3204135709 sameAs 3204135709 @default.
• W3204135709 citedByCount "14" @default.
• W3204135709 countsByYear W32041357092022 @default.
• W3204135709 countsByYear W32041357092023 @default.
• W3204135709 crossrefType "journal-article" @default.
• W3204135709 hasAuthorship W3204135709A5007517961 @default.
• W3204135709 hasAuthorship W3204135709A5007697163 @default.
• W3204135709 hasAuthorship W3204135709A5009809054 @default.
• W3204135709 hasAuthorship W3204135709A5010330151 @default.
• W3204135709 hasAuthorship W3204135709A5013439509 @default.
• W3204135709 hasAuthorship W3204135709A5014111921 @default.
• W3204135709 hasAuthorship W3204135709A5016285611 @default.
• W3204135709 hasAuthorship W3204135709A5018546198 @default.
• W3204135709 hasAuthorship W3204135709A5022674970 @default.
• W3204135709 hasAuthorship W3204135709A5023823647 @default.
• W3204135709 hasAuthorship W3204135709A5027617827 @default.
• W3204135709 hasAuthorship W3204135709A5032174515 @default.
• W3204135709 hasAuthorship W3204135709A5040172071 @default.
• W3204135709 hasAuthorship W3204135709A5041823391 @default.
• W3204135709 hasAuthorship W3204135709A5042048122 @default.
• W3204135709 hasAuthorship W3204135709A5045102610 @default.
• W3204135709 hasAuthorship W3204135709A5062313473 @default.
• W3204135709 hasAuthorship W3204135709A5066821523 @default.
• W3204135709 hasAuthorship W3204135709A5067205817 @default.
• W3204135709 hasAuthorship W3204135709A5073181970 @default.
• W3204135709 hasAuthorship W3204135709A5076531502 @default.
• W3204135709 hasAuthorship W3204135709A5077753793 @default.
• W3204135709 hasAuthorship W3204135709A5081768317 @default.
• W3204135709 hasBestOaLocation W32041357091 @default.
• W3204135709 hasConcept C126322002 @default.
• W3204135709 hasConcept C203014093 @default.
• W3204135709 hasConcept C2778780528 @default.
• W3204135709 hasConcept C2779394231 @default.

• next