FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204138838> ?p ?o ?g. }

• W3204138838 abstract "Introduction: Annual vaccination of children against influenza is a key component of vaccination programs in many countries. However, past infection and vaccination may affect an individual's susceptibility to infection. Little research has evaluated whether annual vaccination is the best strategy. Using the United Kingdom as our motivating example, we assess the impact of different childhood vaccination strategies, specifically annual and biennial (every other year), on attack rate and expected number of infections. Methods and Findings: We present a multi-annual, individual-based, stochastic, force of infection model that accounts for individual exposure histories and disease/vaccine dynamics influencing susceptibility. We simulate birth cohorts that experience yearly influenza epidemics and follow them until age 18 to determine attack rates and the number of childhood infections. We perform simulations under baseline conditions, with an assumed vaccination coverage of 44%, to compare annual vaccination to no and biennial vaccination. We relax our baseline assumptions to explore how our model assumptions impact vaccination program performance. At baseline, we observed more than a 50% reduction in the number of infections between the ages 2 and 10 under annual vaccination in children who had been vaccinated at least half the time compared to no vaccination. When averaged over all ages 0-18, the number of infections under annual vaccination was 2.07 (2.06, 2.08) compared to 2.63 (2.62, 2.64) under no vaccination, and 2.38 (2.37, 2.40) under biennial vaccination. When we introduced a penalty for repeated exposures, we observed a decrease in the difference in infections between the vaccination strategies. Specifically, the difference in childhood infections under biennial compared to annual vaccination decreased from 0.31 to 0.04 as exposure penalty increased. Conclusion: Our results indicate that while annual vaccination averts more childhood infections than biennial vaccination, this difference is small. Our work confirms the value of annual vaccination in children, even with modest vaccination coverage, but also shows that similar benefits of vaccination can be obtained by implementing a biennial vaccination program." @default.
• W3204138838 created "2021-10-11" @default.
• W3204138838 creator A5030841774 @default.
• W3204138838 creator A5091885439 @default.
• W3204138838 date "2021-09-26" @default.
• W3204138838 modified "2023-10-14" @default.
• W3204138838 title "Is annual vaccination best? A modelling study of influenza vaccination strategies in children" @default.
• W3204138838 cites W1598417225 @default.
• W3204138838 cites W1886211768 @default.
• W3204138838 cites W1969471820 @default.
• W3204138838 cites W1983773476 @default.
• W3204138838 cites W1984476090 @default.
• W3204138838 cites W1986462296 @default.
• W3204138838 cites W1989948011 @default.
• W3204138838 cites W2011399872 @default.
• W3204138838 cites W2038669746 @default.
• W3204138838 cites W2041361179 @default.
• W3204138838 cites W2043619935 @default.
• W3204138838 cites W2043759831 @default.
• W3204138838 cites W2043831246 @default.
• W3204138838 cites W2045226599 @default.
• W3204138838 cites W2052690552 @default.
• W3204138838 cites W2060328928 @default.
• W3204138838 cites W2060990215 @default.
• W3204138838 cites W2071657440 @default.
• W3204138838 cites W2072656136 @default.
• W3204138838 cites W2079057108 @default.
• W3204138838 cites W2081097955 @default.
• W3204138838 cites W2090540879 @default.
• W3204138838 cites W2091260381 @default.
• W3204138838 cites W2092500478 @default.
• W3204138838 cites W2095069717 @default.
• W3204138838 cites W2114048332 @default.
• W3204138838 cites W2145389522 @default.
• W3204138838 cites W2145603505 @default.
• W3204138838 cites W2165384760 @default.
• W3204138838 cites W2169565071 @default.
• W3204138838 cites W2516193022 @default.
• W3204138838 cites W2560666415 @default.
• W3204138838 cites W2745379188 @default.
• W3204138838 cites W2775569101 @default.
• W3204138838 cites W2896184201 @default.
• W3204138838 cites W2897207365 @default.
• W3204138838 cites W2912899025 @default.
• W3204138838 cites W2945635369 @default.
• W3204138838 cites W3008120976 @default.
• W3204138838 cites W3016103012 @default.
• W3204138838 cites W3198048121 @default.
• W3204138838 cites W343490654 @default.
• W3204138838 cites W1980566077 @default.
• W3204138838 doi "https://doi.org/10.1101/2021.09.22.21263935" @default.
• W3204138838 hasPublicationYear "2021" @default.
• W3204138838 type Work @default.
• W3204138838 sameAs 3204138838 @default.
• W3204138838 citedByCount "0" @default.
• W3204138838 crossrefType "posted-content" @default.
• W3204138838 hasAuthorship W3204138838A5030841774 @default.
• W3204138838 hasAuthorship W3204138838A5091885439 @default.
• W3204138838 hasBestOaLocation W32041388381 @default.
• W3204138838 hasConcept C12725497 @default.
• W3204138838 hasConcept C144024400 @default.
• W3204138838 hasConcept C149923435 @default.
• W3204138838 hasConcept C187212893 @default.
• W3204138838 hasConcept C203014093 @default.
• W3204138838 hasConcept C22070199 @default.
• W3204138838 hasConcept C505870484 @default.
• W3204138838 hasConcept C71924100 @default.
• W3204138838 hasConcept C86803240 @default.
• W3204138838 hasConcept C99454951 @default.
• W3204138838 hasConceptScore W3204138838C12725497 @default.
• W3204138838 hasConceptScore W3204138838C144024400 @default.
• W3204138838 hasConceptScore W3204138838C149923435 @default.
• W3204138838 hasConceptScore W3204138838C187212893 @default.
• W3204138838 hasConceptScore W3204138838C203014093 @default.
• W3204138838 hasConceptScore W3204138838C22070199 @default.
• W3204138838 hasConceptScore W3204138838C505870484 @default.
• W3204138838 hasConceptScore W3204138838C71924100 @default.
• W3204138838 hasConceptScore W3204138838C86803240 @default.
• W3204138838 hasConceptScore W3204138838C99454951 @default.
• W3204138838 hasLocation W32041388381 @default.
• W3204138838 hasOpenAccess W3204138838 @default.
• W3204138838 hasPrimaryLocation W32041388381 @default.
• W3204138838 hasRelatedWork W11642185 @default.
• W3204138838 hasRelatedWork W11968491 @default.
• W3204138838 hasRelatedWork W12101721 @default.
• W3204138838 hasRelatedWork W13211282 @default.
• W3204138838 hasRelatedWork W13228241 @default.
• W3204138838 hasRelatedWork W14283252 @default.
• W3204138838 hasRelatedWork W20646140 @default.
• W3204138838 hasRelatedWork W237175 @default.
• W3204138838 hasRelatedWork W5227915 @default.
• W3204138838 hasRelatedWork W969878 @default.
• W3204138838 isParatext "false" @default.
• W3204138838 isRetracted "false" @default.
• W3204138838 magId "3204138838" @default.
• W3204138838 workType "article" @default.