FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204142120> ?p ?o ?g. }

• W3204142120 endingPage "634" @default.
• W3204142120 startingPage "624" @default.
• W3204142120 abstract "Albumin is the most abundant protein in blood plasma and acts as a carrier for many circulating molecules. Hypoalbuminaemia, mostly caused by either renal or liver disease or malnutrition, can perturb vascular homeostasis and is involved in the development of multiple diseases. Here we review four functions of albumin and the consequences of hypoalbuminaemia on vascular homeostasis. (i) Albumin is the main determinant of plasma colloid osmotic pressure. Hypoalbuminaemia was therefore thought to be the main mechanism for oedema in nephrotic syndrome (NS), however, experimental studies showed that intrarenal mechanisms rather than hypoalbuminaemia determine formation and, in particular, maintenance of oedema. (ii) Albumin functions as an interface between lysophosphatidylcholine (LPC) and circulating factors (lipoproteins and erythrocytes) and the endothelium. Consequently, hypoalbuminaemia results in higher LPC levels in lipoproteins and erythrocyte membrane, thereby increasing atherosclerotic properties of low-density lipoprotein and blood viscosity, respectively. Furthermore, albumin dose-dependently restores LPC-induced inhibition of vasodilation. (iii) Hypoalbuminaemia impacts on vascular nitric oxide (NO) signalling by directly increasing NO production in endothelial cells, leading to reduced NO sensitivity of vascular smooth muscle cells. (iv) Lastly, albumin binds free fatty acids (FFAs). FFAs can induce vascular smooth muscle cell apoptosis, uncouple endothelial NO synthase and decrease endothelium-dependent vasodilation. Unbound FFAs can increase the formation of reactive oxygen species by mitochondrial uncoupling in multiple cell types and induce hypertriglyceridemia in NS. In conclusion, albumin acts as an interface in the circulation and hypoalbuminaemia impairs multiple aspects of vascular function that may underlie the association of hypoalbuminaemia with adverse outcomes. However, hypoalbuminaemia is not a key to oedema in NS. These insights have therapeutic implications." @default.
• W3204142120 created "2021-10-11" @default.
• W3204142120 creator A5062438369 @default.
• W3204142120 creator A5086741505 @default.
• W3204142120 date "2021-10-05" @default.
• W3204142120 modified "2023-10-16" @default.
• W3204142120 title "Albumin is an interface between blood plasma and cell membrane, and not just a sponge" @default.
• W3204142120 cites W1511302815 @default.
• W3204142120 cites W159273832 @default.
• W3204142120 cites W1598742325 @default.
• W3204142120 cites W1886701750 @default.
• W3204142120 cites W1937472617 @default.
• W3204142120 cites W1963805558 @default.
• W3204142120 cites W1966316513 @default.
• W3204142120 cites W1966976103 @default.
• W3204142120 cites W1967695807 @default.
• W3204142120 cites W1976367987 @default.
• W3204142120 cites W1977382728 @default.
• W3204142120 cites W1980962793 @default.
• W3204142120 cites W1983886923 @default.
• W3204142120 cites W1984056319 @default.
• W3204142120 cites W1988625441 @default.
• W3204142120 cites W1989371402 @default.
• W3204142120 cites W1990999359 @default.
• W3204142120 cites W1991424350 @default.
• W3204142120 cites W1991448459 @default.
• W3204142120 cites W1992553477 @default.
• W3204142120 cites W1994393781 @default.
• W3204142120 cites W1999251926 @default.
• W3204142120 cites W2001805808 @default.
• W3204142120 cites W2002192155 @default.
• W3204142120 cites W2006836179 @default.
• W3204142120 cites W2007496527 @default.
• W3204142120 cites W2020200556 @default.
• W3204142120 cites W2020792115 @default.
• W3204142120 cites W2021360010 @default.
• W3204142120 cites W2022880021 @default.
• W3204142120 cites W2027328052 @default.
• W3204142120 cites W2027555966 @default.
• W3204142120 cites W2030108481 @default.
• W3204142120 cites W2035138737 @default.
• W3204142120 cites W2037833933 @default.
• W3204142120 cites W2040852689 @default.
• W3204142120 cites W2044487577 @default.
• W3204142120 cites W2045029019 @default.
• W3204142120 cites W2045365086 @default.
• W3204142120 cites W2046022256 @default.
• W3204142120 cites W2047230864 @default.
• W3204142120 cites W2048539937 @default.
• W3204142120 cites W2057459959 @default.
• W3204142120 cites W2058609970 @default.
• W3204142120 cites W2059277045 @default.
• W3204142120 cites W2064974523 @default.
• W3204142120 cites W2065418343 @default.
• W3204142120 cites W2066154380 @default.
• W3204142120 cites W2067742653 @default.
• W3204142120 cites W2068734467 @default.
• W3204142120 cites W2070051688 @default.
• W3204142120 cites W2074417648 @default.
• W3204142120 cites W2076364750 @default.
• W3204142120 cites W2077220588 @default.
• W3204142120 cites W2077514923 @default.
• W3204142120 cites W2078313955 @default.
• W3204142120 cites W2086599127 @default.
• W3204142120 cites W2087934100 @default.
• W3204142120 cites W2088145115 @default.
• W3204142120 cites W2089162544 @default.
• W3204142120 cites W2090652826 @default.
• W3204142120 cites W2093021792 @default.
• W3204142120 cites W2100098337 @default.
• W3204142120 cites W2103727400 @default.
• W3204142120 cites W2104310075 @default.
• W3204142120 cites W2111397256 @default.
• W3204142120 cites W2118284746 @default.
• W3204142120 cites W2118934047 @default.
• W3204142120 cites W2123142710 @default.
• W3204142120 cites W2131143996 @default.
• W3204142120 cites W2137442238 @default.
• W3204142120 cites W2138355686 @default.
• W3204142120 cites W2139543324 @default.
• W3204142120 cites W2142381802 @default.
• W3204142120 cites W2144775813 @default.
• W3204142120 cites W2145312804 @default.
• W3204142120 cites W2145936693 @default.
• W3204142120 cites W2147741927 @default.
• W3204142120 cites W2149914661 @default.
• W3204142120 cites W2164531124 @default.
• W3204142120 cites W2170597525 @default.
• W3204142120 cites W2171279232 @default.
• W3204142120 cites W2171877979 @default.
• W3204142120 cites W2182154150 @default.
• W3204142120 cites W2220333392 @default.
• W3204142120 cites W2304869088 @default.
• W3204142120 cites W2344530571 @default.
• W3204142120 cites W2488911476 @default.
• W3204142120 cites W2570969530 @default.
• W3204142120 cites W2581605534 @default.
• W3204142120 cites W2609120769 @default.

• next