FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204142392> ?p ?o ?g. }

• W3204142392 abstract "Abstract Background Data on outcomes for people with gout and COVID-19 are extremely few. Our primary objective was to assess whether gout is a risk factor for diagnosis of COVID-19 and death related to COVID-19. The secondary objectives were to test for sex- and drug-specific differences in risk. Methods We used data from the UK Biobank that included 15,560 people with gout. Multivariable-adjusted logistic regression was employed in the following analyses using a case-control study design: Analysis A, to test for association between gout and COVID-19 diagnosis (n=459,837); Analysis B, to test for association between gout and death related to COVID-19 in a case-control cohort of people who died or survived with COVID-19 (n=16,336); Analysis C, to test for association between gout and death related to COVID-19 in the entire UK Biobank cohort (n=459,837); Analysis D, to stratify by prescription of urate-lowering therapy (ULT) and colchicine on the risk of death related to COVID-19 in a subset of the UK Biobank cohort with medication data (n=341,398). Findings Gout was associated with diagnosis of COVID-19 in analysis A (OR=1.2 [1.1 ; 1.3]) but not with risk of death in the COVID-19-diagnosed group in analysis B. In analysis C gout associated with risk of death related to COVID-19 in the unadjusted model (OR=3.9 [3.3 ; 4.7]), in Model 1 adjusted for demographic factors (OR=1.8 [1.5 ; 2.1]) and in the fully adjusted Model 2 (OR=1.3 [1.1 ; 1.6]). In Analysis C risk was higher in women than men in Model 1 adjusted for demographic factors (OR=3.5 [2.4 ; 5.0] and OR=1.5 [1.2 ; 1.8], respectively) with the difference maintained after additional adjustment for eight metabolic co-morbidities (OR Men =1.2 [0.9 ; 1.5], OR Women =1.9 [1.3 ; 2.9]). There were no statistically significant differences in risk of death related to COVID-19 according to prescription of ULT or colchicine. Interpretation Gout is a risk factor for death related to COVID-19 using the UK Biobank cohort with an increased risk in women with gout that was also driven by risk factors outside metabolic co-morbidities of gout. Research in context Evidence before this study There are no studies investigating the risk of COVID-19 diagnosis and risk of death with COVID-19 in people with gout. Added value of this study The findings provide evidence that gout is a risk factor for diagnosis of COVID-19 and that gout is a risk factor for death with COVID-19, independent of included co-morbidities. Women with gout are at a higher risk of death with COVID-19 than men with gout. Implications of the available evidence The new evidence demonstrate that gout is a risk factor for death from COVID-19, particularly in women. This information will inform clinical decision-making in people with gout diagnosed with COVID-19. Future research should focus on replicating these findings, including a focus on understanding key factor(s) explaining the increased risk of death with COVID-19 in women with gout." @default.
• W3204142392 created "2021-10-11" @default.
• W3204142392 creator A5008272034 @default.
• W3204142392 creator A5008504111 @default.
• W3204142392 creator A5046197775 @default.
• W3204142392 creator A5047464345 @default.
• W3204142392 creator A5061552694 @default.
• W3204142392 creator A5086285989 @default.
• W3204142392 date "2021-10-01" @default.
• W3204142392 modified "2023-09-26" @default.
• W3204142392 title "Gout and coronavirus disease-19 (COVID-19): the risk of diagnosis and death in the UK Biobank" @default.
• W3204142392 cites W1994439773 @default.
• W3204142392 cites W2000723131 @default.
• W3204142392 cites W2082704080 @default.
• W3204142392 cites W2150224561 @default.
• W3204142392 cites W2306899700 @default.
• W3204142392 cites W2743011355 @default.
• W3204142392 cites W2910951675 @default.
• W3204142392 cites W3043342124 @default.
• W3204142392 cites W3047144258 @default.
• W3204142392 cites W3080256227 @default.
• W3204142392 cites W3109910417 @default.
• W3204142392 cites W3115055441 @default.
• W3204142392 cites W3116890992 @default.
• W3204142392 cites W3119319978 @default.
• W3204142392 cites W3130857919 @default.
• W3204142392 cites W3135245268 @default.
• W3204142392 cites W3157241833 @default.
• W3204142392 cites W3158521917 @default.
• W3204142392 cites W3164055787 @default.
• W3204142392 cites W3164932383 @default.
• W3204142392 cites W3165495907 @default.
• W3204142392 cites W4206621898 @default.
• W3204142392 doi "https://doi.org/10.1101/2021.09.28.21264270" @default.
• W3204142392 hasPublicationYear "2021" @default.
• W3204142392 type Work @default.
• W3204142392 sameAs 3204142392 @default.
• W3204142392 citedByCount "0" @default.
• W3204142392 crossrefType "posted-content" @default.
• W3204142392 hasAuthorship W3204142392A5008272034 @default.
• W3204142392 hasAuthorship W3204142392A5008504111 @default.
• W3204142392 hasAuthorship W3204142392A5046197775 @default.
• W3204142392 hasAuthorship W3204142392A5047464345 @default.
• W3204142392 hasAuthorship W3204142392A5061552694 @default.
• W3204142392 hasAuthorship W3204142392A5086285989 @default.
• W3204142392 hasBestOaLocation W32041423921 @default.
• W3204142392 hasConcept C116567970 @default.
• W3204142392 hasConcept C126322002 @default.
• W3204142392 hasConcept C151956035 @default.
• W3204142392 hasConcept C201903717 @default.
• W3204142392 hasConcept C2779134260 @default.
• W3204142392 hasConcept C2780402116 @default.
• W3204142392 hasConcept C29374701 @default.
• W3204142392 hasConcept C60644358 @default.
• W3204142392 hasConcept C71924100 @default.
• W3204142392 hasConcept C72563966 @default.
• W3204142392 hasConcept C86803240 @default.
• W3204142392 hasConceptScore W3204142392C116567970 @default.
• W3204142392 hasConceptScore W3204142392C126322002 @default.
• W3204142392 hasConceptScore W3204142392C151956035 @default.
• W3204142392 hasConceptScore W3204142392C201903717 @default.
• W3204142392 hasConceptScore W3204142392C2779134260 @default.
• W3204142392 hasConceptScore W3204142392C2780402116 @default.
• W3204142392 hasConceptScore W3204142392C29374701 @default.
• W3204142392 hasConceptScore W3204142392C60644358 @default.
• W3204142392 hasConceptScore W3204142392C71924100 @default.
• W3204142392 hasConceptScore W3204142392C72563966 @default.
• W3204142392 hasConceptScore W3204142392C86803240 @default.
• W3204142392 hasLocation W32041423921 @default.
• W3204142392 hasOpenAccess W3204142392 @default.
• W3204142392 hasPrimaryLocation W32041423921 @default.
• W3204142392 hasRelatedWork W2125371786 @default.
• W3204142392 hasRelatedWork W2239640831 @default.
• W3204142392 hasRelatedWork W2244622617 @default.
• W3204142392 hasRelatedWork W2249905794 @default.
• W3204142392 hasRelatedWork W2329215203 @default.
• W3204142392 hasRelatedWork W2896073317 @default.
• W3204142392 hasRelatedWork W2902727542 @default.
• W3204142392 hasRelatedWork W3128808981 @default.
• W3204142392 hasRelatedWork W3178008357 @default.
• W3204142392 hasRelatedWork W4308807092 @default.
• W3204142392 isParatext "false" @default.
• W3204142392 isRetracted "false" @default.
• W3204142392 magId "3204142392" @default.
• W3204142392 workType "article" @default.