FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204142725> ?p ?o ?g. }

• W3204142725 endingPage "13" @default.
• W3204142725 startingPage "1" @default.
• W3204142725 abstract "Minimal myelination is proposed to be a contributing factor to the preferential nigral neuronal loss in Parkinson's disease (PD). Similar to nigral dopaminergic neurons, sympathetic neurons innervating the heart have long, thin axons which are unmyelinated or minimally myelinated. Interestingly, cardiac sympathetic loss in PD is heterogeneous across the heart, yet the spatial relationship between myelination and neurodegeneration is unknown. Here, we report the mapping of myelin basic protein (MBP) expression across the left ventricle of normal rhesus macaques (n = 5) and animals intoxicated with systemic 6-OHDA (50 mg/kg iv) to model parkinsonian cardiac neurodegeneration (n = 10). A subset of 6-OHDA-treated rhesus received daily dosing of pioglitazone (5 mg/kg po; n = 5), a PPARγ agonist with neuroprotective properties. In normal animals, MBP-immunoreactivity (-ir) was identified surrounding approximately 14% of axonal fibers within nerve bundles of the left ventricle, with more myelinated nerve fibers at the base level of the left ventricle than the apex (p < 0.014). Greater MBP-ir at the base was related to a greater number of nerve bundles at that level relative to the apex (p < 0.05), as the percent of myelinated nerve fibers in bundles was not significantly different between levels of the heart. Cardiac sympathetic loss following 6-OHDA was associated with decreased MBP-ir in cardiac nerve bundles, with the percent decrease of MBP-ir greater in the apex (84.5%) than the base (52.0%). Interestingly, cardiac regions and levels with more MBP-ir in normal animals showed attenuated sympathetic loss relative to areas with less MBP-ir in 6-OHDA + placebo (r = -0.7, p < 0.014), but not in 6-OHDA + pioglitazone (r = -0.1) subjects. Our results demonstrate that myelination is present around a minority of left ventricle nerve bundle fibers, is heterogeneously distributed in the heart of rhesus macaques, and has a complex relationship with cardiac sympathetic neurodegeneration and neuroprotection." @default.
• W3204142725 created "2021-10-11" @default.
• W3204142725 creator A5004502108 @default.
• W3204142725 creator A5017026384 @default.
• W3204142725 creator A5032465628 @default.
• W3204142725 creator A5048727419 @default.
• W3204142725 creator A5050111281 @default.
• W3204142725 creator A5062812869 @default.
• W3204142725 creator A5073836712 @default.
• W3204142725 creator A5090169144 @default.
• W3204142725 creator A5091187468 @default.
• W3204142725 date "2021-10-04" @default.
• W3204142725 modified "2023-10-15" @default.
• W3204142725 title "Myelin Basic Protein and Cardiac Sympathetic Neurodegeneration in Nonhuman Primates" @default.
• W3204142725 cites W1518897246 @default.
• W3204142725 cites W1598029032 @default.
• W3204142725 cites W1839367987 @default.
• W3204142725 cites W1855500719 @default.
• W3204142725 cites W1895378421 @default.
• W3204142725 cites W1950067960 @default.
• W3204142725 cites W1978499715 @default.
• W3204142725 cites W1979713296 @default.
• W3204142725 cites W1980230515 @default.
• W3204142725 cites W1988786764 @default.
• W3204142725 cites W1992104307 @default.
• W3204142725 cites W2007354597 @default.
• W3204142725 cites W2019608563 @default.
• W3204142725 cites W2053632281 @default.
• W3204142725 cites W2067934376 @default.
• W3204142725 cites W2071666358 @default.
• W3204142725 cites W2073874214 @default.
• W3204142725 cites W2076584134 @default.
• W3204142725 cites W2090736521 @default.
• W3204142725 cites W2093631510 @default.
• W3204142725 cites W2096592917 @default.
• W3204142725 cites W2109453816 @default.
• W3204142725 cites W2113110323 @default.
• W3204142725 cites W2114008335 @default.
• W3204142725 cites W2118659974 @default.
• W3204142725 cites W2123899328 @default.
• W3204142725 cites W2124808208 @default.
• W3204142725 cites W2125178082 @default.
• W3204142725 cites W2143293793 @default.
• W3204142725 cites W2149453681 @default.
• W3204142725 cites W2154069529 @default.
• W3204142725 cites W2158248023 @default.
• W3204142725 cites W2158659583 @default.
• W3204142725 cites W2161313992 @default.
• W3204142725 cites W2171538072 @default.
• W3204142725 cites W2311228285 @default.
• W3204142725 cites W2336465444 @default.
• W3204142725 cites W2340401086 @default.
• W3204142725 cites W2403316906 @default.
• W3204142725 cites W2437607074 @default.
• W3204142725 cites W2469475200 @default.
• W3204142725 cites W2494489538 @default.
• W3204142725 cites W2597734448 @default.
• W3204142725 cites W2617170837 @default.
• W3204142725 cites W2762153312 @default.
• W3204142725 cites W2767378564 @default.
• W3204142725 cites W2773186181 @default.
• W3204142725 cites W2774164535 @default.
• W3204142725 cites W2810221820 @default.
• W3204142725 cites W2903711638 @default.
• W3204142725 cites W2908224589 @default.
• W3204142725 cites W2911366120 @default.
• W3204142725 cites W2955272631 @default.
• W3204142725 cites W3000576401 @default.
• W3204142725 cites W3023848936 @default.
• W3204142725 cites W3036912092 @default.
• W3204142725 cites W4231359634 @default.
• W3204142725 cites W2884833560 @default.
• W3204142725 doi "https://doi.org/10.1155/2021/4776610" @default.
• W3204142725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8505074" @default.
• W3204142725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34646580" @default.
• W3204142725 hasPublicationYear "2021" @default.
• W3204142725 type Work @default.
• W3204142725 sameAs 3204142725 @default.
• W3204142725 citedByCount "1" @default.
• W3204142725 countsByYear W32041427252023 @default.
• W3204142725 crossrefType "journal-article" @default.
• W3204142725 hasAuthorship W3204142725A5004502108 @default.
• W3204142725 hasAuthorship W3204142725A5017026384 @default.
• W3204142725 hasAuthorship W3204142725A5032465628 @default.
• W3204142725 hasAuthorship W3204142725A5048727419 @default.
• W3204142725 hasAuthorship W3204142725A5050111281 @default.
• W3204142725 hasAuthorship W3204142725A5062812869 @default.
• W3204142725 hasAuthorship W3204142725A5073836712 @default.
• W3204142725 hasAuthorship W3204142725A5090169144 @default.
• W3204142725 hasAuthorship W3204142725A5091187468 @default.
• W3204142725 hasBestOaLocation W32041427251 @default.
• W3204142725 hasConcept C105702510 @default.
• W3204142725 hasConcept C126322002 @default.
• W3204142725 hasConcept C134018914 @default.
• W3204142725 hasConcept C25498285 @default.
• W3204142725 hasConcept C2776925932 @default.
• W3204142725 hasConcept C2778609137 @default.
• W3204142725 hasConcept C2778921608 @default.

• next